ANXIETY DISORDERS

This study tests whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can help control tumors better in people with advanced liver or gallbladder cancer who also have depression or anxiety. About 240 participants will be randomly assigned to receive imm…

This study tests whether using a person's genetic information to choose psychiatric drugs leads to better recovery than standard prescribing. About 2,500 adults with depression, anxiety, or psychotic disorders will be randomly assigned to either genetic-guided treatment or usual …

This study tests a brief group therapy called Resilience Training for Teens. It aims to prevent serious mental illness in high school students aged 14-19 who have mild symptoms of depression, anxiety, or unusual feelings. About 70 teens will participate to see if the training hel…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for guided exerc…

This study tests a new therapy called SoundHeal for youth aged 12-18 who are in juvenile detention and struggle with emotions, anxiety, depression, or substance use. The therapy uses a special pod with sound, music, gentle vibrations, and light to help them relax, followed by a s…

This study tests whether brief, online self-guided programs can help parents of children ages 2-7 better manage their child's anxiety. Parents are randomly assigned to one of three programs and report on their child's anxiety over 8 months. The goal is to see if these low-cost to…

This study tests a short, 30-minute online program designed to help caregivers (parents or guardians) of children aged 4-10 with anxiety. The program is being adapted for Latin, Haitian, and Haitian-American families. Researchers will measure changes in caregiver anxiety and how …

This study tests a one-hour online program called UKADO for people waiting to start face-to-face therapy for anxiety or depression. About 312 adults will try different versions of the program to see which works best. The goal is to find a way to help people feel better while they…

This study tests whether transcranial magnetic stimulation (TMS) can reduce anxiety and depression in children and teens aged 6 to 18. About 120 participants will receive TMS treatment, and researchers will measure symptom changes using questionnaires. The goal is to see if this …

This study tests two fast-paced versions of cognitive behavioral therapy for veterans with PTSD and anxiety disorders. About 306 veterans will receive either individual therapy over two weeks, group therapy over two days, or usual care. The goal is to see which format better redu…

This study looks at whether qigong (a gentle movement practice) or multicomponent exercise can help people with panic disorder feel less anxious and improve their physical health. Researchers will enroll 60 adults aged 18-65 who have been diagnosed with panic disorder. Participan…

This study tests whether a brain-training technique called neurofeedback can help people with both coronary heart disease and anxiety. Participants will learn to control a specific brain area using real-time feedback, with the goal of calming their heart rate. The study involves …

This study tests a brain-training technique called neurofeedback in 56 adults with stable heart disease and anxiety. Participants learn to control a brain region linked to stress while exposed to mild cold pain. The goal is to see if real training lowers heart rate more than a sh…

This study tests whether a computer-based cognitive training program can improve thinking skills like memory and attention in 128 adults with anxiety, depression, or PTSD. Participants are randomly assigned to either the active training or a sham version. The goal is to see if th…

This study looks at whether adding a CBD medication (Epidiolex) to cognitive behavioral therapy helps adults with generalized anxiety disorder feel less anxious. About 90 people will take either CBD or a placebo alongside therapy sessions. The goal is to see if the combination im…

This study tests a short-term group therapy that helps people understand their own and others' thoughts and feelings, called mentalization-based therapy, for adults with anxiety or depression. About 100 participants will be randomly assigned to either this new therapy or standard…

This study tests a 4-week mindfulness program for new mothers (up to 12 months postpartum) who have an anxiety disorder. The goal is to see if it reduces anxiety, improves emotion regulation, and increases body awareness. Researchers will use questionnaires and brain scans to mea…

This study tests a telemedicine program called RxWell that teaches coping skills to manage mood and pain after knee or hip replacement. About 150 adults with anxiety or depression symptoms will use the program before and after surgery. The goal is to see if it reduces the need fo…

This study tests a culturally adapted form of cognitive behavioral therapy (CBT) for people living with HIV who also have depression and anxiety. Fifty adults in Peshawar, Pakistan will either receive six therapy sessions from trained health workers or standard care. The main goa…

This study compares two types of exposure therapy for spider phobia: in-person (live spider) and videochat (watching someone else handle a spider). About 72 adults with spider fear will be randomly assigned to one of these treatments or a waiting list. The goal is to see which me…

This study tests whether adding a computer-based music therapy (GCMRT) to standard talk therapy (CBT) works better than CBT alone for children aged 8-17 with anxiety disorders. About 150 participants will receive weekly CBT for 4 weeks, then 8 weeks of CBT plus either GCMRT or a …

This study tests a non-invasive brain stimulation technique called rTMS to see if it can reduce anxiety and improve heart function in women who have had multiple miscarriages and struggle with anxiety. Researchers will use a magnetic coil on the scalp to gently stimulate a brain …

This study tests a new telehealth program called DINOSAUR designed to reduce anxiety in young children (ages 4-6) with autism. The program uses cognitive-behavioral therapy adapted for autistic kids and focuses on helping them cope with uncertainty. Researchers will enroll 70 chi…

This study tests a 3-session program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use. The program teaches veterans about whole health and how to communicate their needs to doctors and loved ones. Researchers want to see if it improves soc…

This study tests a self-help workbook designed for people in prison who have moderate to severe anxiety or depression. About 96 adults will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is helpful, easy to use, and improves me…

This study aims to improve MRI imaging techniques to better understand how mood and anxiety disorders affect the brain. Researchers will scan the brains of healthy volunteers and people with major depressive disorder while they perform tasks or view images. The goal is to develop…

This study looks at how brain activity and thinking patterns relate to anxiety in children aged 8 to 17. Researchers will use brain scans and cognitive tasks to compare anxious children with healthy ones, and track changes over a year of standard treatments like therapy or medica…

This study tests whether an AI tool can reliably measure depression and anxiety severity by analyzing video interviews. About 120 adults with depression or anxiety will complete online questionnaires and talk to both an AI interviewer and human clinicians. The goal is to see if A…

This study screens up to 16,000 people aged 3 to 99 with mood or anxiety disorders, as well as healthy volunteers, to see if they qualify for other research studies at the National Institute of Mental Health. Participants undergo interviews, medical exams, brain scans, and lab te…

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation skills training can help people with mood, anxiety, or related disorders better control their emotions. About 240 adults aged 18-55 who struggle with emotion regulation will be …

This study tests if a device that temporarily changes brain activity (rTMS) can alter how people with anxiety react to fear. About 80 adults who recently started anxiety treatment will have three visits involving surveys, brain measurements, and mild magnetic pulses. The goal is …

This study is looking for genetic markers that may predict which children and youth (ages 6-24) with depression, anxiety, or OCD will experience behavioral activation—a side effect of SSRI antidepressants like Prozac or Zoloft. Researchers will compare the DNA of 160 participants…

This study looks at how the brain reacts to threats in people with depression, anxiety, or both. About 165 adults will take a single dose of an anti-anxiety drug or a placebo and then have their brain activity measured with MRI and eye-blink tests. The goal is to find differences…

This study is testing whether brain scans can predict how well people with depression, insomnia, or social anxiety will respond to internet-delivered cognitive behavioral therapy (iCBT). Researchers will compare brain scan data with patients' own expectations to see which is bett…

This study looks at how exercise affects the brain in adults with anxiety disorders. Researchers will measure specific brain chemicals from blood samples to understand the link between physical activity and reduced anxiety. The study involves 30 sedentary adults aged 18-50, some …

This study uses a non-invasive technology called transcranial focused ultrasound (tFUS) to temporarily change activity in a deep brain area involved in anxiety. Researchers want to see if this affects how people with anxiety disorders react to emotional situations. The study invo…