ACUTE LYMPHOBLASTIC LEUKEMIA

This study aims to cure children with acute lymphoblastic leukemia and lymphoma by personalizing their treatment. Doctors use genetic tests on each child's cancer to choose targeted drugs or advanced immunotherapies. The goal is to improve survival rates and quality of life by ma…

This early-stage trial is testing whether adding specially treated immune cells, called 'veto cells,' can help patients with blood cancers or bone marrow failure after a stem cell transplant. The goal is to help the donor's cells grow in the patient's body without causing a dange…

This large study aims to find the most effective and least burdensome chemotherapy regimens for children and young adults with newly diagnosed, standard-risk B-cell acute lymphoblastic leukemia (ALL) or localized lymphoma. It compares different drug doses and treatment schedules …

This early-phase study is testing the safety and best dose of a targeted radiation treatment, given with two chemotherapy drugs, to prepare patients for a donor stem cell transplant. The goal is to better wipe out cancer cells in the bone marrow before receiving healthy donor cel…

This large, late-stage trial is testing whether adding a targeted immunotherapy drug called blinatumomab to standard chemotherapy helps adults with a specific type of acute lymphoblastic leukemia (ALL) live longer. The study involves nearly 500 adults aged 30-70 who are newly dia…

This trial is testing a stem cell transplant method that uses donors who are not a perfect genetic match. It aims to help adults and children with various blood cancers, like leukemia and lymphoma, when a fully matched donor isn't available. The study will see if this approach, w…

This study is testing a multi-step treatment plan for adults with a specific type of acute lymphoblastic leukemia (ALL) that is linked to a genetic change called the Philadelphia chromosome. The plan combines lower-intensity chemotherapy with two targeted drugs, ponatinib and bli…

This large study aims to determine the best type of donor for stem cell transplants in children and young adults with high-risk leukemia or myelodysplastic syndrome (MDS). It directly compares transplants from a partially matched family member (haploidentical) to those from a ful…

This study is testing whether adding two cancer drugs, bortezomib and vorinostat, to standard chemotherapy is safe and effective for infants under 1 year old with acute lymphoblastic leukemia (ALL). Researchers want to see if this combination helps more babies survive longer with…

This study is testing a new, longer-lasting version of a standard chemotherapy drug (asparaginase) for children and teens with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma. Researchers want to see if giving this new drug, called SC-PEG, every 3 weeks into a vein w…

This study is testing whether adding a targeted drug called inotuzumab ozogamicin to standard treatment can help adults with a specific, newly diagnosed type of acute lymphoblastic leukemia (Ph+ ALL) achieve a deep remission faster. The goal is to see if this approach leads to be…

This study tested a multi-part treatment for adults with a specific, aggressive type of acute lymphoblastic leukemia (ALL). The goal was to see if combining intensive chemotherapy, a targeted drug called dasatinib, and for some patients, a stem cell transplant from a donor, could…

This study tests a personalized treatment called CAR-T cell therapy for children and young adults whose B-cell blood cancers have returned or resisted standard treatments. Doctors collect a patient's own immune cells, modify them in a lab to better target cancer cells, and then i…

This early-stage trial is testing a new version of CAR-T cell therapy called huCART19-IL18 for adults with certain blood cancers that have returned or not responded to standard treatments. The study aims to find a safe dose and see if the therapy can be reliably manufactured. It …

This study is testing if using a lower dose of a standard drug (cyclophosphamide) given after a stem cell transplant can reduce serious infections in the first 100 days. The trial aims to see if this lower dose is just as good at preventing graft-versus-host disease, a common and…

This study is testing a targeted drug called inotuzumab ozogamicin for adults with B-cell acute lymphoblastic leukemia (ALL) who are in remission but still have tiny amounts of cancer cells detectable by sensitive tests. The drug is designed to seek out and destroy these remainin…

This study is testing a new type of treatment for people whose acute lymphoblastic leukemia (ALL) has come back or hasn't responded to other therapies. Doctors take a patient's own immune cells (T cells), genetically modify them to better find and attack leukemia cells, and add a…

This study is testing two different treatment plans for adults aged 65 and older with a type of blood cancer called acute lymphoblastic leukemia (ALL). One plan combines an immunotherapy drug (blinatumomab) with standard chemotherapy. The other plan combines a targeted drug (dasa…

This study allows patients already receiving venetoclax in other trials to continue treatment if they are benefiting and tolerating it well. The main goal is to collect long-term safety information by tracking any side effects. It includes about 165 patients with various blood ca…

This study is testing a new type of personalized immune cell therapy called rapcabtagene autoleucel (a CAR-T cell therapy) for adults with several aggressive or returning blood cancers. The main goals are to find a safe and effective dose and to see if the therapy can shrink or e…

This study is testing whether adding the drug ponatinib to a specific chemotherapy regimen and another drug called venetoclax can help patients whose T-cell acute lymphoblastic leukemia has returned or not responded to prior treatment. It aims to see if this combination can put t…

This study is testing a new, more targeted form of radiation as a preparatory step before a stem cell transplant. It is for patients with certain types of leukemia or myelodysplastic syndrome who need a transplant but do not have a fully matched donor. The goal is to see if this …

This trial is for children and young adults with a specific, aggressive type of leukemia (Ph+ ALL). It tests whether a standard chemotherapy regimen works as well as a stronger one when both are given with the targeted drug imatinib, aiming to maintain high cure rates while reduc…

This study is testing a combination of intensive chemotherapy (called Hyper-CVAD) and a targeted drug called ponatinib for adults with a specific type of acute lymphoblastic leukemia (ALL) that involves a genetic change called Philadelphia chromosome or BCR-ABL. The main goal is …

This study tested a comprehensive support program to help children with acute lymphoblastic leukemia (ALL) take their daily oral chemotherapy medication more consistently. It compared a high-tech program with smart pill bottles and text reminders against standard education alone.…

This early-stage study is testing whether immune cells from healthy donors, given along with two other drugs, are safe for people with advanced colorectal, stomach, or hard-to-treat blood cancers. The goal is to see if this combination helps the donor immune cells last longer in …

This large French study aims to find the best way to give a key drug called pegaspargase to children and teenagers with acute lymphoblastic leukemia (ALL). The drug works by starving the leukemia cells. Researchers are comparing two different dosing schedules to see which one is …

This study is testing several FDA-approved CAR-T cell therapies for patients whose blood cancers have returned or not responded to standard treatments. It involves about 150 participants with conditions like acute lymphoblastic leukemia and various lymphomas. The main goals are t…

This is an early-stage study testing the safety and dosing of a new experimental drug called GNC-038 in adults with aggressive blood cancers that have returned or not responded to standard treatments. The drug is a 'quad-specific antibody' designed to attack cancer cells by bindi…

This study is testing a new blood test called AlloHeme to see if it can predict when leukemia or a related blood cancer might return after a patient receives a bone marrow transplant. Researchers will track over 300 patients for two years, collecting regular blood and bone marrow…

This study is testing a vaccine designed to prevent cytomegalovirus (CMV) infection in adults with blood cancers who are receiving a half-matched stem cell transplant. CMV is a common virus that can become life-threatening when the immune system is weakened after transplant. The …

This study is testing whether an iPad-based brain training program is practical and helpful for children and young adults who have had stem cell transplants for leukemia. Researchers want to see if participants can complete the program and whether it helps maintain memory, attent…

This study tests whether a digital coaching program for parents can help children who have survived leukemia or lymphoma do better in school. Many kids face learning and memory challenges after cancer treatment. The program provides parents with educational tips and support throu…

This study tests whether a special parenting skills program helps Latino children who have survived leukemia or lymphoma do better in school. Researchers are comparing an intensive 8-session training for parents against a standard single-session meeting to see which improves chil…

This study is testing whether a drug called siltuximab can help control two serious side effects that sometimes occur after CAR-T cell therapy for blood cancers. CAR-T therapy can cause dangerous immune overreactions called cytokine release syndrome (CRS) and neurological problem…

This study collects white blood cells from people with certain leukemias or lymphomas that have not been cured by standard treatments. The cells are collected through a 4-6 hour blood filtering process called leukapheresis and then frozen. The goal is to have these cells ready an…

This study collects blood or bone marrow samples from people with blood cancers like leukemia and lymphoma. Researchers will study these samples in the lab to better understand how these cancers work and to find new targets for future treatments. The study does not test a new the…

This study aims to understand why cancer survivors who receive stem cell transplants have a higher risk of heart disease. Researchers will measure how well the heart, lungs, and muscles work together in 350 adult patients before their transplant and for two years after. The goal …

This study aims to measure and understand the financial stress and worry parents experience while their child is being treated for acute lymphoblastic leukemia (ALL). Researchers will survey 100 parents at different points during their child's treatment to see how money worries c…

This study aims to understand why many young adults who survived childhood cancer experience early signs of aging and frailty, which can lead to serious health problems later in life. Researchers will follow over 1,500 survivors for five years, measuring their physical fitness an…