New hope for leukemia patients: study tests stronger Pre-Transplant regimen
NCT ID NCT03821610
First seen May 05, 2026 · Last updated May 21, 2026 · Updated 4 times
Summary
This study compares two different chemotherapy and radiation regimens given before a stem cell transplant for adults with acute lymphoblastic leukemia (ALL) in remission. The goal is to see if a stronger regimen can reduce the chance of the cancer returning without increasing the risk of transplant-related death. About 242 patients aged 40-70 will be randomly assigned to receive either the standard fludarabine/melphalan or cyclophosphamide with low-dose total body irradiation.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Barts Health Nhs Trust
London, E11BB, United Kingdom
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Cambridge University Hospitals Nhs Foundation Trust
Cambridge, CB20QQ, United Kingdom
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Cardiff and Vale University Health Board
Cardiff, CF144XW, United Kingdom
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Central Manchester University Hospitals Nhs Foundation Trust
Manchester, United Kingdom
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Heart of England Nhs Foundation Trust
Birmingham, B95ST, United Kingdom
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Imperial College Healthcare Nhs Trust
London, W21NY, United Kingdom
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Kings College Hospital
London, SE5 9RS, United Kingdom
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Leeds Teaching Hospitals Nhs Trust
Leeds, LS9 7TF, United Kingdom
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NHS Greater Glasgow and Clyde
Glasgow, G12 0YN, United Kingdom
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Nottingham University Hospitals Nhs Trust
Nottingham, NG72UH, United Kingdom
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Oxford University Hospitals Nhs Foundation Trust
Oxford, OX3 9DU, United Kingdom
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Plymouth Hospitals Nhs Trust
Plymouth, PL68DH, United Kingdom
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Sheffield Teaching Hospitals Nhs Foundation Trust
Sheffield, S57AU, United Kingdom
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The Christie Nhs Foundation Trust
Manchester, M204BX, United Kingdom
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The Clatterbridge Cancer Centre Nhs Foundation Trust
Liverpool, CH634JY, United Kingdom
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The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
Newcastle, United Kingdom
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The Royal Marsden Nhs Foundation Trust
London, SW3 6JJ, United Kingdom
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University College London Hospitals Nhs Foundation Trust
London, NW12PG, United Kingdom
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University Hospital Southampton Nhs Foundation Trust
Southampton, SO16 6YD, United Kingdom
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University Hospitals Birmingham Nhs Foundation Trust
Birmingham, United Kingdom
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University Hospitals Bristol Nhs Foundation Trust
Bristol, BS13NU, United Kingdom
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University Hospitals of Leicester Nhs Trust
Leicester, LE15WW, United Kingdom
Conditions
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