ACUTE LYMPHOBLASTIC LEUKEMIA
Clinical trials for ACUTE LYMPHOBLASTIC LEUKEMIA explained in plain language.
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Promising combo tackles tough leukemias in early trial
Disease control CompletedThis early-phase study tested a combination of two drugs—veliparib and temozolomide—in 66 adults with acute leukemias that had come back or not responded to standard treatment. The goal was to find the safest dose and see how well the combo worked. Veliparib blocks a repair enzym…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 03:26 UTC
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New drug combo may reduce deadly transplant complication in blood cancer patients
Disease control CompletedThis study looked at 174 adults with blood cancers who received a stem cell transplant from an unrelated donor. Researchers compared different combinations of immune-suppressing drugs to find the best way to prevent graft-versus-host disease (GVHD), a serious complication where d…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE3 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated May 26, 2026 03:17 UTC
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Engineered immune cells show promise against hard-to-treat childhood blood cancers
Disease control CompletedThis study tested a new treatment for children and young adults (ages 1-39) with B-cell leukemia or lymphoma that did not respond to standard therapy. Researchers took participants' white blood cells, modified them in a lab to target the CD22 protein on cancer cells, and infused …
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 03:13 UTC
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New radiation technique aims to make stem cell transplants safer for leukemia patients
Disease control CompletedThis study tested a new way to deliver radiation before a stem cell transplant for people with acute lymphoblastic leukemia (ALL). Instead of radiating the whole body, the new method (TMLI) targets only the bone marrow and lymph nodes to reduce side effects. The study included 14…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: NA • Sponsor: Hospital Universitario Dr. Jose E. Gonzalez • Aim: Disease control
Last updated May 26, 2026 03:13 UTC
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New drug combo may make bone marrow transplants safer for blood cancer patients
Disease control CompletedThis study looked at a new way to do bone marrow transplants for people with blood cancers like leukemia and lymphoma who don't have a perfectly matched donor. Instead of using a standard drug after transplant, doctors tested a different drug called bendamustine to see if it coul…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE1 • Sponsor: University of Arizona • Aim: Disease control
Last updated May 26, 2026 03:11 UTC
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Tailored chemo dosing shows promise for adult leukemia patients
Disease control CompletedThis study tested whether giving personalized doses of the chemotherapy drug L-asparaginase to adults (ages 18-50) with untreated acute lymphoblastic leukemia (ALL) is safe and feasible. Researchers aimed to see if patients could complete all 30 planned doses after achieving remi…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated May 26, 2026 03:11 UTC
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Personalized plans may boost transplant survival in seniors
Disease control CompletedThis study tested a personalized geriatric optimization plan (GO!) in 30 patients over 60 receiving a stem cell transplant for blood cancers or bone marrow failure. The plan included tailored changes to diet, sleep, activity, and medications. The goal was to see if these changes …
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Disease control
Last updated May 26, 2026 03:11 UTC
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Half-Matched donor transplant offers hope for blood cancer patients
Disease control CompletedThis study tested a less intense stem cell transplant for people with various blood cancers who are older or have other health issues. It used a half-matched family donor (like a parent or sibling) and a milder chemo and radiation preparation. The goal was to see how many patient…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated May 26, 2026 03:05 UTC
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Experimental CAR-T therapy targets Hard-to-Treat cancers in early trial
Disease control CompletedThis early-phase study tested an experimental therapy called PRGN-3007 UltraCAR-T cells in 3 adults with advanced blood cancers (like leukemia and lymphoma) or triple-negative breast cancer. The main goal was to find the safest dose and see if the treatment could shrink tumors. B…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated May 22, 2026 14:01 UTC
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New approach boosts medication adherence in young leukemia patients
Disease control CompletedThis study tested two methods to help children with acute lymphoblastic leukemia (ALL) take their daily chemotherapy pill (mercaptopurine) as prescribed. About 570 children in remission were assigned to either an educational program or a more intensive intervention. The goal was …
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE3 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated May 22, 2026 13:54 UTC
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Tailored combo therapy shows promise for tough blood cancers
Disease control CompletedThis study tested a personalized, intensive treatment plan for over 1,000 adults newly diagnosed with acute lymphoblastic leukemia or lymphoblastic lymphoma. The approach used pediatric-style chemotherapy, targeted drugs, and stem cell transplants based on each patient's risk lev…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE3 • Sponsor: Goethe University • Aim: Disease control
Last updated May 18, 2026 12:02 UTC
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New hope for chinese adults with Tough-to-Treat leukemia: targeted drug shows promise
Disease control CompletedThis study tested a drug called inotuzumab ozogamicin in 44 adults from China whose acute lymphoblastic leukemia (ALL) had come back or stopped responding to other treatments. The goal was to see if the drug could make the cancer disappear or reduce it significantly. The drug wor…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE4 • Sponsor: Pfizer • Aim: Disease control
Last updated May 08, 2026 12:02 UTC
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PET scans reveal hidden leukemia spots that could impact CAR t success
Knowledge-focused CompletedThis study tested whether a special PET-CT scan could find leukemia hiding outside the bone marrow in people with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia (ALL). Ten participants received a PET scan before getting CAR T-cell therapy. The goal was to see how o…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated May 26, 2026 03:12 UTC
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Which donor search path leads to better survival?
Knowledge-focused CompletedThis study looked at over 1,700 people with blood cancers or disorders who needed a bone marrow transplant. Researchers compared two strategies: first searching for a matched unrelated donor and then an alternative if needed, versus going straight to an alternative donor. The goa…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: NA • Sponsor: Center for International Blood and Marrow Transplant Research • Aim: Knowledge-focused
Last updated May 26, 2026 02:48 UTC
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Hidden danger: mold infections threaten kids on leukemia treatment
Knowledge-focused CompletedThis study looked back at 621 children in Denmark who had chemotherapy for acute leukemia between 2008 and 2022. Researchers wanted to find out how many got serious mold infections, how many died from them, and what made some children more likely to get infected. The goal is to b…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Sponsor: University of Southern Denmark • Aim: Knowledge-focused
Last updated May 22, 2026 14:03 UTC
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Could tiny particles explain clot danger in Kids' leukemia treatment?
Knowledge-focused CompletedThis study looked at tiny cell fragments called microparticles in 24 children with acute lymphoblastic leukemia. The goal was to see if these particles, released when leukemia cells die or blood vessels are damaged, make blood clots more likely during treatment. Researchers measu…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: NA • Sponsor: CHU de Reims • Aim: Knowledge-focused
Last updated May 22, 2026 14:02 UTC
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IPad brain training tested in young cancer survivors after transplant
Knowledge-focused CompletedThis study looked at whether children and teens who had a stem cell transplant for leukemia could use an iPad-based program to help their thinking and memory. Only 17 participants were enrolled, and the main goal was to see if the program was practical and if kids would stick wit…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: NA • Sponsor: Stanford University • Aim: Knowledge-focused
Last updated May 22, 2026 13:54 UTC
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Italian study reviews Real-World use of targeted leukemia drug
Knowledge-focused CompletedThis study looked back at the medical records of 84 people with acute lymphoblastic leukemia (ALL) who received a drug called anti-CD22 outside of clinical trials in Italy. The goal was to learn more about the drug's side effects, how well it worked, and its costs in everyday hos…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Sponsor: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS • Aim: Knowledge-focused
Last updated May 19, 2026 11:59 UTC