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Engineered immune cells show promise against tough childhood cancers

NCT ID NCT02315612

First seen Nov 20, 2025 · Last updated Jun 18, 2026 · Updated 29 times

Summary

This study tested a new treatment for children and young adults (ages 1-39) with B-cell leukemia or lymphoma that did not respond to standard therapy. Researchers took the patients' own white blood cells, modified them in a lab to target the CD22 protein on cancer cells, and infused them back. The main goals were to check safety and see if the treatment could shrink or eliminate the cancer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia B-cell acute lymphoblastic leukemia B-cell neoplasm B-cell non-Hodgkin lymphoma Burkitt lymphoma follicular lymphoma interdigitating dendritic cell sarcoma large B-cell lymphoma lymphoma non-Hodgkin lymphoma precursor B-cell acute lymphoblastic leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.