Refractory plasma cell neoplasm

This trial is testing an experimental therapy called CT0596, which uses a patient's own immune cells that are engineered to recognize and attack multiple myeloma cells. The study includes adults with relapsed or refractory multiple myeloma who have already tried at least three pr…

This phase 1 trial tests VV169, a therapy that aims to create CAR-T cells inside the body to fight multiple myeloma. Researchers give VV169 as an infusion to adults whose cancer has returned or stopped responding to at least three prior treatments. The study focuses on safety, fi…

This early-phase trial tests a new approach called PICX Injection, a CAR-T cell therapy that is prepared inside the patient's body rather than in a lab. It is for people with multiple myeloma that has returned or not responded to at least two prior treatments. The study will eval…

This study tests whether adding low-dose radiation to the drug elranatamab can better kill cancer cells in people with multiple myeloma that has come back or not responded to treatment and has spread outside the bone. About 34 adults will receive the combination. The goal is to s…

This study tests a new antibody drug called HuL001, given together with two standard myeloma drugs (lenalidomide and dexamethasone), in 21 adults whose multiple myeloma has returned or stopped responding to prior treatments. The goal is to see if the combination is safe and can s…

This Phase 3 trial tests a new drug called IBI3003 against standard treatments for people with multiple myeloma that has returned or is not responding to therapy. About 255 participants will be randomly assigned to receive either IBI3003 or a standard treatment chosen by their do…

This study is testing whether people with multiple myeloma that has come back or stopped responding to other treatments can safely take a lower dose of the drug linvoseltamab once their cancer starts to improve. Linvoseltamab works by helping the body's immune cells find and kill…

This study tests two drugs, elranatamab and isatuximab, given as shots under the skin for people with multiple myeloma that has returned or not responded to at least two prior treatments. The goal is to see if the combination can shrink tumors and control the disease. About 30 pa…

This phase II trial compares a new combination of daratumumab and teclistamab against standard treatments for high-risk multiple myeloma that has relapsed or not responded to therapy. About 80 adults will be randomly assigned to either the new combo or usual care. The goal is to …

This early-stage trial is testing a new treatment called KSVCBD for people with multiple myeloma that has come back or not responded to at least three prior treatments. KSVCBD is a type of CAR-T cell therapy given directly into the body to target two proteins (CD19 and BCMA) on m…

This phase 3 trial is testing a new CAR-T cell therapy called arlo-cel against standard treatments for adults with multiple myeloma that has come back or stopped responding to previous therapies. About 440 participants will receive either arlo-cel or a standard regimen. The study…

This study tests a new drug called sonrotoclax, alone or with other medicines, in people with a type of multiple myeloma that has come back or stopped responding to treatment. The trial includes 246 participants and aims to find the safest and most effective dose. Researchers wil…

This early-phase trial is testing a combination of two drugs—teclistamab and iberdomide—in people with multiple myeloma that has come back or stopped responding to treatment. The goal is to find the safest and most effective dose of iberdomide when used with teclistamab. About 26…

This study tests a new drug, linvoseltamab, alone or with another drug called carfilzomib, against standard treatments for people with multiple myeloma that has returned or not responded to prior therapy. About 915 participants who have had 1 to 3 prior treatments will be enrolle…

This early-phase study tests a new drug called RO7851624 in 160 people with relapsed/refractory multiple myeloma who have tried several standard treatments. The main goal is to check the drug's safety and how the body processes it. Researchers will also look for signs that the dr…

This early-phase study tests a new experimental drug, REGN17372, combined with another drug called linvoseltamab in people with relapsed or refractory multiple myeloma (cancer that has returned or stopped responding to treatment). The main goals are to check safety, find the best…

This study tests whether giving tocilizumab before the first dose of linvoseltamab can lower the risk of cytokine release syndrome (CRS) in people with relapsed or refractory multiple myeloma. The 30 participants have already tried at least four prior treatments. Researchers will…

This study tests an experimental drug called LBL-034 in people whose multiple myeloma has returned or no longer responds to standard treatments. The trial has two phases: first, finding the safest dose, and then checking how well the drug shrinks tumors. About 342 adults will tak…

This Phase 3 trial is testing whether a new drug called mezigdomide, combined with two standard drugs (bortezomib and dexamethasone), works better than the current standard combination (pomalidomide, bortezomib, and dexamethasone) for people with multiple myeloma that has come ba…

This study tests whether the drug elranatamab can be given safely in an outpatient clinic instead of the hospital for people with multiple myeloma that has come back or stopped responding to treatment. About 46 adults will receive the drug along with a single preventive dose of a…

This early-stage trial is testing whether combining two drugs, cevostamab and elranatamab, is safe and tolerable for people with multiple myeloma that has returned or not responded to prior treatments. About 120 participants will receive the drugs, and researchers will monitor si…

This study tests whether adding the drug selinexor to standard bispecific antibody therapy can help people with relapsed or refractory multiple myeloma achieve deeper remissions. About 27 adults who have already tried at least 4 prior treatments will take selinexor alongside thei…

This study tests two drugs, mezigdomide and elranatamab, together in people with multiple myeloma that has come back or stopped responding to prior treatments. The goal is to find the safest dose and see if the combination can shrink tumors. About 62 adults will take part in this…

This study tests a new treatment called AZD0120, which uses a patient's own immune cells engineered to attack two targets (BCMA and CD19) on myeloma cells. It is for people whose multiple myeloma has returned or stopped responding to prior treatments. The study compares AZD0120 t…

This phase 2 study tests whether the drug elranatamab can lower the chance of multiple myeloma worsening after treatment with idecabtagene vicleucel (a CAR-T cell therapy). The study will enroll 32 adults with relapsed or refractory multiple myeloma. Participants will receive elr…

This study tests a combination of four drugs—selinexor, carfilzomib, isatuximab, and dexamethasone—in people whose multiple myeloma has come back or stopped responding to treatment. The trial has two parts: first, a small safety run-in to find the right dose, then a larger group …

This early-stage trial tests a new gene therapy called KLN-1010 for people with multiple myeloma that has come back or stopped responding to treatment. Instead of removing cells and engineering them in a lab, this therapy works inside the body to create special immune cells that …

This early-phase study tests an experimental drug called JNJ-79635322, a trispecific antibody designed to attack cancer cells in people with relapsed or refractory multiple myeloma or AL amyloidosis. About 180 participants will receive the drug to find a safe dose and check for s…

This early-stage trial tests a new drug called SIM0500 in 130 adults with multiple myeloma that has returned or stopped responding to treatment. SIM0500 is a tri-specific antibody designed to help the immune system attack cancer cells. The study will first find the safest dose, t…

This study tests an experimental drug called JNJ-79635322 in people with multiple myeloma that has returned or stopped responding after at least 3 prior treatments. The goal is to see how well the drug shrinks or controls the cancer. About 157 participants will receive the drug a…

This phase 1 trial tests an experimental therapy called MDC-CAR-BCMA001 in adults with relapsed or refractory B-cell cancers, including multiple myeloma and diffuse large B-cell lymphoma. The treatment uses a patient's own immune cells, modified to target a protein called BCMA on…

This study tests a new treatment called AZD4045, which uses specially engineered immune cells (CAR-T cells) to target and kill multiple myeloma cells. The therapy is given alone or combined with other drugs (daratumumab and aldesleukin) in adults whose myeloma has returned or sto…

This phase II trial at Mayo Clinic is testing whether adding dasatinib and quercetin to standard CAR-T therapy can improve outcomes for people with multiple myeloma that has returned or not responded to prior treatments. The study will enroll 44 adults who have already tried at l…

This study tests whether giving the drug belantamab mafodotin less often, combined with other standard cancer medicines, can still control multiple myeloma while reducing side effects like eye problems. About 200 adults whose cancer has returned or stopped responding to prior tre…

This trial tests a new approach for people with multiple myeloma that has come back or not responded to treatment. Doctors take immune cells from donated cord blood, genetically engineer them to better recognize and attack myeloma cells, and give them back to the patient along wi…

This phase 3 trial is testing whether adding an experimental drug called inobrodib to a standard two-drug regimen (pomalidomide and dexamethasone) can help people whose multiple myeloma has come back or stopped responding to prior treatments. Participants will be randomly assigne…

This pilot study tests whether drinking tea made from soursop leaves can reduce the number of cancer cells in people with relapsed or refractory acute myeloid leukemia (AML) or multiple myeloma (MM) — blood cancers that have not responded to standard treatments. About 20 particip…

This early-stage trial tests an experimental oral drug called KTX-1001 in people with multiple myeloma that has returned or not responded to prior treatments. The drug works by blocking a protein that helps myeloma cells grow. The study will enroll 165 adults and will also test K…

This phase II trial tests a combination of three drugs—mezigdomide, carfilzomib, and dexamethasone—in 28 patients with multiple myeloma that has returned or not responded to treatment and has spread to soft tissues or organs. The goal is to see if this combo can shrink tumors or …

This study tests a new treatment called AZD0120 for people with multiple myeloma that has come back or stopped responding to at least three prior therapies. AZD0120 is a personalized cell therapy that reprograms a patient's own immune cells to attack two targets on myeloma cells …

This study compares a new combination of teclistamab and pomalidomide against the standard treatment (carfilzomib, pomalidomide, and dexamethasone) for multiple myeloma that has come back after improvement. About 162 adults with relapsed or refractory myeloma will take part. The …

This early-phase trial tests whether adding an experimental drug called SX-682 to a standard three-drug regimen is safe for people with multiple myeloma that has relapsed or become resistant. SX-682 works by freeing up immune cells to better kill cancer cells. The study will enro…

This study tests a new drug, cemsidomide, combined with dexamethasone in people with multiple myeloma that has returned or not responded to at least three prior treatments. About 100 adults will receive the drug combo to see if it shrinks tumors and how safe it is. The goal is to…

This study tests a new experimental drug, REGN7945, combined with another experimental drug, linvoseltamab, in people with multiple myeloma that has returned or not responded to at least three prior treatments. The goal is to see if the combination is safe and can shrink tumors b…

This study tests a new drug, inobrodib, combined with two standard medicines (pomalidomide and dexamethasone) in 100 adults whose multiple myeloma has come back or no longer responds to available therapies. The goal is to see how well the combination shrinks tumors and to learn m…

This study tests a new drug called mRNA-2808 in people with multiple myeloma that has returned or not responded to standard treatments. The drug is given through a vein and aims to control the cancer. The trial will check for side effects and measure how well the drug works. Abou…

This study looks at whether giving extra antibodies (immunoglobulins) can help prevent serious infections in people with multiple myeloma who are being treated with a new kind of immunotherapy called a BCMA-directed T cell engager. About 80 adults who have already tried at least …

This early-stage trial tests whether adding a drug called NT-I7 (a lab-made immune booster) can help CAR-T cells survive longer in people with multiple myeloma that has come back or stopped responding to treatment. About 52 participants who are already getting standard CAR-T ther…

This phase II trial is testing different doses and schedules of belantamab mafodotin, a drug that delivers chemotherapy directly to myeloma cells. The goal is to find a way to give the drug that causes fewer severe eye problems while still controlling the cancer. About 62 adults …

This early-phase study tests a new treatment called CAR BCMA-CD70 CAR-T for people with high-risk plasma cell neoplasms, a type of blood cancer. The therapy uses the patient's own immune cells, modified to target two cancer markers (BCMA and CD70), to attack the disease. The main…

This study tests an experimental drug called SG2918 in 40 people with relapsed or refractory multiple myeloma, a type of blood cancer that has returned or stopped responding to standard treatments. The main goal is to check the drug's safety and how well the body tolerates it, wi…

This trial investigates a personalized cell therapy called CAR-T, which reprograms a patient's own immune cells to recognize and attack a protein (BCMA) on multiple myeloma cells. The study enrolls 10 adults whose cancer has returned or become resistant after at least three prior…

This phase 2 trial tests whether infliximab, a drug that blocks inflammation, can prevent cytokine release syndrome (CRS) in people with relapsed or refractory multiple myeloma receiving teclistamab or talquetamab. CRS is a common and sometimes serious side effect of these treatm…

This study tests a new way of giving the drug elranatamab to people with multiple myeloma that has come back or stopped responding to other treatments. The goal is to see if giving the drug less often and outside the hospital can reduce side effects and hospital stays. About 40 a…

This umbrella trial tests the drug isatuximab (Sarclisa) combined with several newer agents, with or without dexamethasone, in adults whose multiple myeloma has returned or stopped responding to at least two prior treatments. About 258 participants will be assigned to different s…

This early-phase study tests a new form of curcumin (the active ingredient in turmeric) that is wrapped in tiny fat particles to help the body absorb it better. The goal is to find the safest dose for people with multiple myeloma that has come back or stopped responding to standa…

This early-phase trial tests a genetically modified virus (VSV-IFNβ-NIS) alone or with chemotherapy and immunotherapy drugs in people with blood cancers like multiple myeloma, acute myeloid leukemia, and lymphomas that have returned or not responded to treatment. The virus is des…

This early-phase trial is testing a new type of gene therapy called CAR 70-BCMA dual-target CAR-T for people with relapsed or refractory plasma cell neoplasms, including multiple myeloma. The therapy involves taking a patient's own immune cells, re-engineering them to recognize a…

This study tests several combinations of the experimental drug QLS32015 with other medicines in 160 people whose multiple myeloma has come back or stopped responding to prior therapy. The goal is to see which combination works best to shrink tumors and achieve deep remission. Par…

This phase 2 trial tests whether adding leflunomide to the standard drugs pomalidomide and dexamethasone can better control multiple myeloma that has come back or is resistant to treatment. About 29 adults with relapsed or refractory myeloma will receive the three-drug combinatio…

This study tests a new drug called QLS32015 against two standard treatment combinations (pomalidomide with dexamethasone or selinexor with dexamethasone) in 228 people with multiple myeloma that has relapsed or is refractory. The main goal is to see if QLS32015 can delay cancer p…

This early-stage trial tests a new drug called OPN-6602, alone or with a steroid, in 130 people whose multiple myeloma has returned or stopped responding to at least three prior treatments. The main goal is to check safety and find the right dose. It's too early to know if it wil…

This study tests a new drug called F182112 against standard treatments in 261 adults with multiple myeloma that has returned or stopped responding to prior therapies. The goal is to see if the new drug can delay cancer growth longer than usual care. Participants must have already…

This early-stage trial tests whether adding a personalized cancer vaccine (made from a patient's own immune cells and tumor cells) to standard CAR-T cell therapy can safely improve outcomes for people with multiple myeloma that has returned or stopped responding to treatment. Abo…

This early-phase study tests whether combining a personalized cancer vaccine (made from a patient's own tumor and immune cells) with the drug elranatamab is safe and feasible for people with multiple myeloma that has returned or stopped responding to prior treatments. Up to 25 pa…

This early-stage study tests two drugs—mezigdomide (a pill) and talquetamab (an injection)—in people with multiple myeloma that has come back or stopped responding to prior treatments. The main goal is to find a safe dose and schedule. About 25 participants will receive the drugs…

This study is testing whether adding the drug epunamin to a standard chemotherapy regimen (DECP) can help people with relapsed or refractory multiple myeloma, a type of blood cancer that has not responded to previous treatments. The study will enroll 48 adults aged 18 to 75 and t…

This phase 3 trial is testing a new drug called GR1803 against a standard three-drug combination (daratumumab, pomalidomide, and dexamethasone) in people with multiple myeloma that has come back after 1 to 3 prior treatments. About 358 participants will be randomly assigned to re…

This early-stage study tests a new antibody drug (SAR446523) given as a shot under the skin for people with multiple myeloma that has returned or stopped responding to at least three prior treatments. The study has two parts: first, finding the safest and most effective dose, the…

This study tests a treatment called anti BCMA CAR-T cell therapy for adults with multiple myeloma that has come back or not responded to standard treatments. The therapy uses a patient's own immune cells, modified to target and kill myeloma cells. The trial aims to see if it is s…

This early-phase trial tests a combination of three drugs—talquetamab, iberdomide, and dexamethasone—in people with multiple myeloma that has returned or stopped responding to prior treatments. The goal is to find the safest dose and check for side effects. About 32 adults will t…

This phase 2 trial is testing whether a combination of four drugs—iberdomide, daratumumab, carfilzomib, and dexamethasone—can shrink or prevent the return of multiple myeloma in patients whose cancer has relapsed or stopped responding to prior treatments. About 30 participants wi…

This phase 3 study tests a new drug, linvoseltamab, against a standard three-drug combo (EPd) in people with multiple myeloma that has returned after 1-4 prior treatments. About 410 adults will be randomly assigned to receive either linvoseltamab or EPd. The goal is to see which …

This study tests a new method of giving the drug isatuximab (Sarclisa) under the skin using a wearable device, combined with two other drugs (carfilzomib and dexamethasone), in 64 adults with multiple myeloma that has returned or not responded to prior therapy. The main goal is t…

This early-phase study is testing a new drug called YKST02 in 70 people with multiple myeloma that has relapsed or not responded to at least two prior treatments. YKST02 is a bispecific antibody designed to attach to both myeloma cells and immune cells, helping the immune system …

This study tests a drug called selinexor combined with a low-dose steroid (dexamethasone) in people with multiple myeloma that has stopped responding to many other treatments. Some participants will also receive another drug, bortezomib. The goal is to see if these combinations c…

This early-stage trial tests a new cell therapy called O&D-001 for people with multiple myeloma that has come back or stopped responding to treatment. The therapy uses a patient's own immune cells, modified to attack two cancer targets (BCMA and GPRC5D). The study will enroll 18 …

This study tests a combination of four drugs (isatuximab, belantamab mafodotin, pomalidomide, and dexamethasone) in 50 adults whose multiple myeloma has returned or not responded to prior treatments. The main goal is to see how many patients respond to the therapy. This is not a …

This early-phase study tests a two-step treatment for people with multiple myeloma that has come back or stopped responding to other therapies. First, patients receive talquetamab, a drug that helps the immune system attack cancer cells. Then, they get an infusion of their own ge…

This study tests a new drug called F182112 given with different treatment plans for people whose multiple myeloma has returned or stopped responding to prior therapies. About 90 participants will receive the drug combination to see if it shrinks tumors and how safe it is. The goa…

This study tests whether adding two drugs (elotuzumab and iberdomide) plus a steroid after CAR T-cell therapy can help control multiple myeloma that has come back or not responded to treatment. About 49 adults who have already tried at least four other treatments will take part. …

This study tests a combination of two drugs, mezigdomide and elranatamab, in 75 people with relapsed or refractory multiple myeloma (a blood cancer that has come back or stopped responding to treatment). The goal is to see how well the combination works and how safe it is. Partic…

This study is testing whether the antiviral drug letermovir can prevent a common and serious viral infection called CMV in people with relapsed/refractory multiple myeloma who are receiving the immunotherapy elranatamab. The trial will enroll 40 adults who are CMV-positive. Resea…

This early study tests a new treatment called BCMA-UCART for adults with multiple myeloma that has come back or stopped responding to other therapies. The treatment uses donor immune cells that are specially designed to find and attack cancer cells. The main goals are to see if t…

This early-stage study tests a new cell therapy that targets two proteins (BCMA and CD19) on myeloma cells. It is for patients whose multiple myeloma has returned or not responded to treatment and has spread outside the bone marrow. The main goal is to check the safety of this ap…

This early-phase trial is testing a new type of immune cell therapy that targets two proteins (BCMA and GPRC5D) on myeloma cells. It is for patients whose multiple myeloma has come back or stopped responding to treatment and has spread to other parts of the body. The main goal is…

This early-stage trial tests a new treatment for multiple myeloma that has come back or stopped responding to standard therapies. The treatment combines a cancer-targeting antibody (daratumumab) with a radioactive payload to deliver radiation directly to cancer cells. The study a…

This early-phase study tests a new treatment called CT0596 CAR-T cells for people with multiple myeloma or plasma cell leukemia that has come back or not responded to standard therapies. The main goals are to check safety, find the best dose, and see how well it controls the canc…

This early-stage trial is testing a new type of immune cell therapy called BCMA-CD19 cCAR T cells in 12 patients with multiple myeloma or plasmacytoid lymphoma that has come back or not responded to standard treatments. The therapy uses a patient's own modified immune cells to at…

This phase 2 trial is testing whether a radioactive tracer called 18F-fluciclovine can detect multiple myeloma better than the standard FDG tracer during PET/CT scans. The study will enroll 60 adults with newly diagnosed or relapsed/refractory multiple myeloma. Each participant w…

This study tests whether certain mouth rinses or oral medications can prevent or reduce taste changes caused by the drug talquetamab, used to treat multiple myeloma. About 210 participants will be randomly assigned to different preventive treatments. The goal is to find a way to …

This study tests an online cognitive training program called I-CAN in 90 adults with relapsed multiple myeloma or B-cell non-Hodgkin lymphoma who are about to receive CAR-T cell therapy. The training aims to reduce the memory, attention, and thinking problems that often follow ca…

This study looks at whether adding early palliative care to standard treatment helps people with multiple myeloma or aggressive B-cell lymphoma feel better. About 144 patients and their caregivers will be randomly assigned to receive either usual care alone or usual care plus ear…

This study looks at whether non-chemo approaches like physical activity, intermittent fasting, or adding a beta-blocker (propranolol) can improve immune function and quality of life in people with multiple myeloma or related blood disorders. Researchers will measure changes in im…

This study collects information from about 900 people with relapsed/refractory multiple myeloma who received teclistamab or talquetamab in regular medical practice, not in a clinical trial. Researchers will look at how well the drugs work, how long benefits last, and what side ef…

This study follows about 300 people with multiple myeloma that has come back or stopped responding to treatment. Researchers will watch how well standard treatments work in real-life settings over 24 months, focusing on response rates, safety, and how patients feel. The goal is t…

This study observes older patients (60+) receiving standard CAR-T therapy for blood cancers. Researchers track how treatment affects daily activities, thinking skills, and overall quality of life. No extra treatments are given—just careful monitoring to learn more about patient e…