Obsessive-compulsive disorder

This study tests whether a single low dose of ketamine can quickly reduce obsessive-compulsive disorder (OCD) symptoms. Adults with OCD will receive either ketamine or a comparison drug, and researchers will measure symptom changes using a standard OCD scale. The trial also uses …

This trial compares two psychological treatments for obsessive-compulsive disorder (OCD): metacognitive therapy, which focuses on changing unhelpful thinking patterns, and exposure and response prevention, the current standard behavioral therapy. The study aims to see if metacogn…

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This study tests whether deep brain stimulation (DBS) — a device that sends electrical pulses to specific brain areas — can help people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Participants receive a DBS implant targeting two …

Researchers are testing transcranial direct current stimulation (tDCS), a non-invasive technique that applies a weak electrical current to the scalp, in adults with severe obsessive-compulsive disorder that has not improved with at least two antidepressants. The study compares ac…

Researchers are testing whether transcranial direct current stimulation (tDCS) can reduce symptoms in people with severe obsessive-compulsive disorder that has not improved with standard medications. The study enrolls 20 adults aged 18 to 70 who have chronic OCD and have tried at…

This study tested whether a computerized training program that targets emotional reactions can help relieve obsessive thoughts and compulsive behaviors in people with OCD. Five adults with OCD completed 14 training sessions over three weeks. The goal was to see if this approach c…

This pilot study explores whether adding improv comedy to standard cognitive behavioral therapy (CBT) can help adults with obsessive-compulsive disorder (OCD). Participants will take part in therapist-led group sessions that combine exposure and response prevention (ERP) with imp…

This small study tested whether Epidiolex (a prescription CBD oil) can safely reduce symptoms of obsessive-compulsive disorder, hair-pulling, Tourette syndrome, and hoarding. Four adults took the drug for two weeks. The goal was to see if symptoms improved and if the drug was wel…

This study tests a personalized cognitive training program called CBM-TAF for adults with obsessive-compulsive (OC) symptoms. The program targets a specific thinking pattern known as thought-action fusion (TAF), where people believe having an unwanted thought is as bad as acting …

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This study tested a type of talk therapy called natural psychotherapy, based on Morita therapy and adapted for Chinese culture, in 80 adults with obsessive-compulsive disorder (OCD). The goal was to see if it could reduce OCD symptoms, measured by standard scales. Participants at…

This completed study tested two psychological techniques—imagery rescripting and imaginal exposure—in 6 adults with obsessive-compulsive disorder (OCD) who experience distressing future-oriented images. Participants completed daily and periodic questionnaires to track symptoms. T…

This Phase 3 trial tested whether adding troriluzole to standard OCD medications could reduce symptoms better than a placebo. The study enrolled 589 adults with OCD who had not responded well enough to their current treatment. After 8 weeks, troriluzole did not lead to significan…

This study tested whether a 6-week group therapy program (cognitive behaviour therapy) could help reduce anxiety and stress in pregnant women and new mothers. 72 women from Manitoba, Canada, who were pregnant or within 12 months postpartum and had an anxiety disorder took part. T…

This study tested whether a 6-session educational program could help people receiving electroconvulsive therapy (ECT) feel less stigma and anxiety about their mental health treatment. Sixty adult inpatients with conditions like depression or bipolar disorder took part. Those who …

This study tested a 30-minute web-based program for parents of children with anxiety who are waiting for cognitive behavioral therapy. The program aims to reduce how much parents accommodate their child's anxiety, which can make anxiety worse. Researchers recruited 47 parents and…

This completed Phase 1 trial tested transcranial direct current stimulation (tDCS) in 42 adults with obsessive-compulsive disorder (OCD). Participants received 10 sessions of either low-dose, higher-dose, or fake (sham) electrical stimulation over five days. The goal was to see i…

This study tested a type of therapy called Emotion Regulation Therapy - Attention Regulation (AR-ERT) to help people with obsessive-compulsive disorder, generalized anxiety disorder, or major depressive disorder who struggle with repetitive negative thinking. 65 adults in Massach…

This study tested whether a gentle electrical current applied to the scalp (tDCS) can reduce symptoms of major depression, schizophrenia, OCD, generalized anxiety, and insomnia. 320 adults aged 16–65 received multiple sessions over weeks. Researchers measured symptom changes usin…

This study tested whether a non-invasive brain stimulation technique called TMS could reduce symptoms of obsessive-compulsive disorder (OCD) in 26 adults. The treatment targeted a brain area involved in movement planning. Researchers also looked for clues about how TMS works and …

This study tested a new way of delivering care for people with anxiety and depression in Danish general practices. 302 adults with conditions like panic disorder, social anxiety, or PTSD took part. The model involved a team of doctors, nurses, and therapists working together, and…

This completed Phase 2/3 trial tested whether adding troriluzole to standard antidepressant treatment can reduce OCD symptoms. 426 adults with moderate-to-severe OCD who had not responded well enough to their current medication took either troriluzole or a placebo for 12 weeks. T…

This study tested whether a stepped-care internet-based cognitive behavior therapy (ICBT) with reduced support is as effective as traditional group therapy for obsessive-compulsive disorder (OCD). 95 adults with moderate to severe OCD took part. The goal was to see if the online …

This study tested whether adding troriluzole to standard OCD treatment works better than a placebo. It involved 456 adults with OCD who hadn't fully responded to their current medication. The main goal was to see if troriluzole could further reduce OCD symptoms and improve daily …

This study tested a mobile app called GGOC-AD designed to reduce obsessive-compulsive disorder (OCD) symptoms in adolescents aged 15 to 18. The app presents statements that users accept or reject to challenge unhelpful beliefs linked to OCD. Researchers compared the app to a neut…

This study tested a new, short, and intensive therapy called HANDS-ON for 12 teens (ages 10-18) with anxiety or obsessive-compulsive disorder (OCD) who hadn't improved with standard therapy. The treatment involved personalized exposure exercises done at home and school, with help…

This study tested a treatment called repetitive Transcranial Magnetic Stimulation (rTMS) for Obsessive Compulsive Disorder (OCD). 30 adults with OCD received either real or fake (placebo) rTMS to see if it changes blood flow in a brain area linked to OCD. The goal was to understa…

This completed study at Massachusetts General Hospital tested whether a gentle brain stimulation technique called tDCS could help 86 adults with obsessive-compulsive disorder (OCD) unlearn fear responses. Participants received either real or fake (sham) stimulation while undergoi…

This study looks at how the brains of children aged 9 to 12 with anxiety disorders respond to making mistakes. Researchers measure two types of brain activity: one after an error and one after a balance disturbance. Half of the children will use a 45-minute computer program desig…

This study looked at how electrical brain stimulation influences approach and avoidance behavior in 13 patients with deep brain stimulators for OCD, depression, or epilepsy. Participants played a computer task with their stimulator turned on and off. The goal was to understand br…

This completed study surveyed 3,100 adults in Slovakia to find out how many people have mental disorders like depression, anxiety, PTSD, or addiction. Researchers used a standard interview tool to measure current and lifetime rates, and looked at who gets help and who doesn't. Th…

This study tested whether non-invasive brain stimulation combined with computer-based training can change brain activity and reduce compulsive behaviors in people with OCD. 203 adults with problematic compulsions participated. The goal was to understand how a specific brain regio…

This study looked at how attention and daydreaming influence obsessive thoughts in people with Obsessive Compulsive Disorder (OCD). Researchers compared 80 participants—some with OCD and some without—to see if obsessions change depending on how much the mind wanders. The goal was…

This study tested a mobile app called esTOCma, a serious game designed to teach teachers about obsessive-compulsive disorder (OCD) and reduce stigma. 175 teachers used the app for 10 days or did nothing. Researchers measured changes in OCD knowledge, attitudes, and confidence in …

This study looked at how people with obsessive-compulsive disorder (OCD) balance between using habits and goal-directed thinking when making decisions. Researchers used brain scans and mild electrical stimulation to understand the brain circuits involved. The goal was to learn mo…

This study followed 559 children and teens ages 6 to 19 in the McLean Anxiety Mastery Program to see if their anxiety and depression improved with treatment. Researchers compared patients who received treatment to those on a waitlist and checked if gains lasted three months after…

This study looked at how two different types of cognitive behavioral therapy (CBT) affect brain activity in people with obsessive-compulsive disorder (OCD). Thirty-five adults with OCD completed 15 therapy sessions and had brain scans before, during, and after treatment. The goal…