Nutritional deficiency disease

This study tests a new, personalized version of a weight-loss surgery called SADI-S. Surgeons will measure each patient's small intestine and adjust the bypass length to maximize weight loss while lowering the risk of vitamin deficiencies. The study includes 40 adults with obesit…

This study tests whether early, personalized nutritional support and a simple home exercise program can prevent weight loss and improve quality of life in 200 adults with lung, colorectal, ovarian, or pancreatic cancer starting palliative chemotherapy. Participants receive guidan…

This study tests whether adding choline to a peanut-based therapeutic food improves cognitive development in 1,500 Malawian children aged 6-59 months with severe acute malnutrition. Half get standard food, half get food with extra choline. All also receive amoxicillin. The goal i…

This study tests whether adding choline (a nutrient found in eggs and meat) to a standard food supplement helps children with moderate acute malnutrition avoid becoming severely malnourished. About 1,500 children aged 6 to 59 months in Malawi will receive either the standard supp…

This trial tests whether an enhanced therapeutic formula, F-60, is as safe as the current standard F-75 for children hospitalized with severe acute malnutrition. The study will compare safety and early recovery outcomes in 320 children aged 6 to 59 months. If F-60 is safe and eff…

This study tests whether adding creatine and HMB supplements to a supervised exercise program can improve physical function, muscle mass, thinking skills, and quality of life in frail older adults living in nursing homes. Fifty people aged 65 and older are taking part, receiving …

This study tests whether giving severely malnourished children lower-calorie feeds during the first stage of hospital treatment is safe and helps them survive. About 135 children aged 6 months to 5 years will receive either a standard feed or one of two reduced-calorie feeds. Res…

This study tests four new ready-to-drink nutritional supplements in 100 adults who are malnourished or at risk. Participants take one of the supplements daily for 28 days alongside their usual diet. Researchers track how well people stick with the drink, their nutrient intake, an…

This study tests whether adding a daily nutrient supplement (SQ-LNS) to monthly malaria prevention visits can reduce both malaria and malnutrition in children aged 6-24 months in Burkina Faso. Researchers will compare malaria rates and nutritional status between children receivin…

This study tests a new oral nutritional supplement called AYMES SWIFT in 40 adults who are malnourished or at risk of malnutrition. Participants will take the supplement for 7 days, and researchers will measure how well they tolerate it (digestive comfort) and how much they like …

This study tests whether a special food supplement with added omega-3s and choline can help undernourished pregnant women carry their babies longer and improve their babies' brain development. It also tests a simple talk therapy program to reduce depression during and after pregn…

This study looks at whether providing daily nutritional supplements (like instant milk or soy drinks) can improve the health of malnourished older adults who live alone. Thirty participants will receive these supplements for 12 months while researchers track changes in their nutr…

This study compares two weight-loss surgeries for people with severe obesity (BMI over 45). One is the standard duodenal switch, and the other is a simpler version called SADI. Researchers track weight loss, health improvements like diabetes and high blood pressure, and complicat…

This study tests whether giving a special nutrient mixture (Olimel N12) during hemodialysis can help prevent muscle loss and improve quality of life in people with end-stage kidney disease. About 166 patients will receive either the nutrient infusion or a simple glucose solution …

This study aims to help moderately malnourished children aged 7-23 months in Punjab, Pakistan grow healthy by teaching mothers better feeding, hygiene, and care practices. About 350 mother-child pairs will take part in a program where women support each other using local solution…

This study looks at whether a personalized exercise and nutrition plan can prevent older adults (70+) from losing strength and independence during a hospital stay. About 25 patients in a geriatric ward will try supervised resistance exercises, with some also getting a tailored di…

This pilot study tests whether providing weekly food deliveries and bi-weekly nutrition counseling to mothers can improve growth in malnourished children aged 6-12 months in Lusaka, Zambia. The goal is to see if better basic nutrition can reduce stunting, which affects over half …

This study looks at whether taking a daily multivitamin can prevent vitamin and mineral deficiencies in people using GLP-1 drugs (like tirzepatide) for weight loss. About 246 adults with obesity who have been on a stable GLP-1 dose for at least 3 months will be randomly assigned …

This study looks at whether a special drink made with easily digested protein and MCT oil can help improve malnutrition in cancer patients who are having radiotherapy. The study will follow 132 adults with head and neck, lung, rectal, or esophageal cancer for 12 weeks. Researcher…

This study tests whether improved nutritional support, delivered through digital tools and personalized advice, can reduce malnutrition in cancer patients. Around 130 adults with gynecologic, colorectal, or lymphoma cancers will receive either standard dietary advice or enhanced …

This trial tests a combined nutrition education package for mothers of children under five in Debre Berhan, Ethiopia. The program promotes dietary diversity, limits high-energy foods, and guides food choices to address undernutrition and overnutrition at the same time. Researcher…

This study tests whether two dietary supplements, Congaplex and Immuplex, can improve age-related changes in fingernail ridges and hair health. Researchers will enroll 90 healthy adults aged 18 to 75 who have vertical nail ridges. Participants will take the supplements or an acti…

This study looks at how well children aged 1 to 16 tolerate and accept new nutritional feeds made from real food ingredients. The feeds are given through a tube or as a drink. Researchers will track stomach issues like pain, bloating, and nausea over 28 days. The goal is to see i…

This study tests a new ready-to-use nutritional supplement drink designed for people with dysphagia (swallowing problems). Over 28 days, 40 adults who need at least 250 calories per day from a milkshake-style supplement will take the drink daily. Researchers will check how well p…

This study was designed to see if giving pregnant women nutrition advice based on their unique biology, lifestyle, and health could improve their health and their baby's health. It planned to enroll women less than 20 weeks pregnant, excluding those with high-risk conditions. How…

This study tests a virtual training program called CHOICE+ for staff in long-term care homes. The goal is to improve the mealtime experience for elderly residents, helping them eat better and stay healthier. About 800 residents, staff, and family members from 13-18 homes will tak…

This pilot study looks at how well young children absorb iron from special nutrient supplements. Researchers will give 30 children in Kenya (ages 1-3) a supplement with a harmless iron tracer, then measure iron levels in their blood two weeks later. Half the children are healthy,…

This pilot study in Guinea-Bissau will see if monthly growth checks by local health workers can reduce severe malnutrition in children aged 6 months to 5 years. About 400 children from two villages will take part. The study also compares three ways to measure arm size to find the…

This study in 140 rural secondary schools in Madagascar tests which parts of a hygiene program — new latrines and handwashing stations, peer-led sensitization, or free sanitary pad vouchers — most improve adolescent girls' learning, stress, and physical health. Researchers will m…

This pilot study tests a step-by-step nutrition care plan called P-INPAC for children in the hospital. The goal is to see if training staff and using simple screening tools can help catch and manage malnutrition early. About 600 children across three hospitals will be involved, a…

This study observes 69 adults with chronic kidney disease who are on hemodialysis. Researchers want to find the best way to diagnose malnutrition using the GLIM criteria and other tools. The goal is to see which methods best predict declines in quality of life, muscle strength, a…

This study looks at whether it is practical to offer a blood test for DHA (a nutrient important for baby's brain development) to all pregnant women early in their care. About 650 patients starting prenatal care at participating clinics will be invited to take the test. The main g…

This study aimed to see if a 6-month nutrition plan could improve weight and strength in malnourished older adults compared to standard hospital care. It was designed for people aged 65 and older in Italian hospitals. However, the study was withdrawn before enrolling any particip…

This study looks at how the bacteria in a pregnant woman's gut (her microbiome) and her nutrition affect her baby's growth and health. Researchers are following 800 young pregnant women (28 and under) in Toronto throughout pregnancy and for a year after birth. They collect stool,…

This observational study measures how common malnutrition is in people with relapsing-remitting multiple sclerosis (RRMS) and whether it is linked to disability. Researchers will assess nutritional status, body composition, and other factors like depression and incontinence in 16…

This study looks at how to improve a parenting program for malnourished children aged 6-24 months in Bangladesh. Researchers are testing two approaches: one using program-supplied toys and another where mothers make toys. The goal is to see if these strategies improve children's …

This study follows 70 healthy infants from rural Pakistan over their first two years of life. Researchers will regularly test the babies' gut bacteria to see how it changes and whether it relates to their growth and nutrition. The goal is to understand why some children become ma…

This study tests whether providing technology training and digital nutrition education can improve diet quality, physical activity, and reduce social isolation among older adults who attend meal programs. About 369 participants aged 60 and older who lack tech access or skills wil…

This study follows 1,800 adults with reduced kidney function (not on dialysis) to see how nutrition and lifestyle affect their health. Researchers will track changes in kidney function, heart health, bone health, and thinking skills over time. The goal is to find better ways to m…

This study looks at how a program that helps families lift themselves out of poverty affects the growth and learning of children aged 0-9 in Uganda. Researchers will compare kids in families that received the program to those that did not, measuring things like height, anemia, th…

This study looks at whether giving extra amino acids to critically ill patients on breathing machines helps their bodies build more protein. Researchers will measure protein balance using special tracers. The goal is to understand how nutrition affects recovery in the ICU. About …

This study follows 1,304 healthy Indian adolescents aged 8–10 over time to see how their growth, bone health, and muscle development are linked to their parents' nutrition. Researchers aim to understand why malnutrition persists across generations and identify windows of opportun…