Nephrolithiasis

This trial tests two disposable mini-flexible ureteroscopes, one thinner than the other, for removing kidney stones up to 15 mm. Researchers randomly assign adults to receive surgery with either the 6.3Fr or the 7.5Fr scope. They compare how completely stones are cleared, whether…

This trial compares two ways of finishing kidney stone removal surgery. In one, a medical glue called Glubran 2 is sprayed into the access tract to seal it, avoiding the need for a drainage tube. In the other, a standard tube is placed. The study aims to see if the glue technique…

This study tests a new device that combines a camera and suction in one tool for kidney stone removal surgery. About 75 adults with kidney stones between 0.5 and 2.0 cm will undergo the procedure to see if the device safely clears stones and reduces leftover fragments. The goal i…

This trial compares three ways to remove kidney stones using a scope inserted through the urinary tract. Some patients will have the procedure without a protective sheath, while others will use a flexible sheath, with either low or high laser power. The goal is to see which appro…

This trial tests four different breathing strategies during kidney stone surgery to see if reducing kidney motion helps surgeons remove stones more completely and lowers the risk of complications. Eighty adults undergoing the procedure will be randomly assigned to standard ventil…

This trial tests whether a new flexible and navigable suction ureteral access sheath (FANS) works better than the standard sheath for removing kidney stones smaller than 2 cm in children. Sixty children will be randomly assigned to one of the two devices during a procedure called…

This trial tests whether a vacuum-assisted ureteral access sheath (ClearPetra) removes kidney stones more completely than a standard rigid sheath (Navigator) during flexible ureteroscopy. About 156 adults with stones 1-3 cm will be randomly assigned to one sheath. The main goal i…

This study compares two suction-assisted techniques used during minimally invasive kidney stone surgery. The goal is to see which method better clears stones and lowers the risk of infection. About 126 adults with medium-sized kidney stones (2-3 cm) will be randomly assigned to o…

This study tests whether L-methionine, a natural amino acid, can make urine more acidic in people who form calcium phosphate kidney stones. These stones tend to form in alkaline urine, and current medications can sometimes make the problem worse. Fifteen participants will follow …

This study compares a new tool called the CVAC system, used with a special scope, to standard treatments for removing kidney stones. About 1,000 adults who need stone removal will be randomly assigned to either the new method or usual care. The main goal is to see if the new appr…

This study compares a cheap medicine, sodium bicarbonate, to the standard prescription potassium citrate for preventing kidney stones. About 30 adults with a history of stones and low urinary citrate will take one of the two medicines. The goal is to see if sodium bicarbonate can…

This study will compare two laser power settings (high vs low) during a minimally invasive surgery called mini-percutaneous nephrolithotomy for removing kidney stones larger than 20 mm. Seventy adults will be randomly assigned to one of the two laser groups. The main goal is to s…

This study will test three different forms of potassium citrate—a medication that helps prevent kidney stones by making urine less acidic. Twenty adults who have had kidney stones will take each form for one week, with a week off in between. Researchers will measure changes in ur…

This trial tests a new way to remove kidney stones using a special laser and a flexible suction sheath. 140 adults with stones between 6mm and 20mm will be randomly assigned to get the new suction sheath or a standard sheath. The goal is to see if the new method clears more stone…

This study compares two methods of using shock waves to break up kidney stones. One method uses the same energy level throughout, while the other starts with low energy and gradually increases it. The goal is to see which approach clears stones more completely and requires fewer …

This study compares two surgical methods for removing large staghorn kidney stones: flexible ureteroscopy (FURS) and percutaneous nephrolithotomy (PCNL). PCNL is the standard but can cause serious complications; FURS is less invasive but may need multiple sessions. The trial will…

This study compares two positions—lying on your back (lithotomy) versus lying on your side (lateral)—during a minimally invasive surgery for kidney stones smaller than 2 cm. The goal is to see which position helps clear stones more completely. Seventy adults with lower calyx kidn…

This study will compare two minimally invasive surgeries for kidney stones that are 2-3 cm in size. About 280 adults across nine hospitals will be randomly assigned to either FANS-based flexible ureteroscopy or suction-assisted mini-PCNL. The main goal is to see which method remo…

This study compares two common procedures—flexible ureteroscopy (a scope through the urinary tract) and shock wave lithotripsy (sound waves to break stones)—for treating small kidney stones (≤15 mm) located in the lower calyx. Researchers will enroll 70 adults and check which met…

This study compares a new surgical tool called VISOR to a standard scope for removing kidney stones. VISOR combines suction, pressure control, and laser to break up and remove stones in one step. About 100 adults with stones up to 3 cm will be randomly assigned to get either VISO…

This study compares a new surgical technique, antegrade flexible ureteroscopy-assisted PCNL, to standard PCNL for removing large, branching kidney stones (staghorn calculi). The goal is to see if the new method removes more stone fragments and causes fewer complications. The tria…

This trial tests whether monitoring pressure inside the kidney during a procedure called percutaneous nephrolithotomy, used to remove kidney stones in children, can lower the chance of post-operative infections. Researchers will enroll 80 children under 18 who need this surgery. …

Paraffin disease happens when people inject paraffin oil into muscle for cosmetic enlargement, causing chronic inflammation, high blood calcium, kidney stones, and kidney damage. Researchers are testing whether empagliflozin or losartan, two drugs already used for kidney protecti…

This study tests whether rinsing the kidney with an antibiotic called dioxidine right after stone-removal surgery can stop infection-related stones from returning. About 95 adults with infection-type kidney stones will get either standard surgery alone or surgery plus the rinse. …

This study tests whether personalized dietary counseling through video visits can help people who have had kidney stones eat less salt. One hundred adults with a history of calcium-based kidney stones will receive either standard advice or virtual home coaching. The goal is to se…

Researchers test whether a single intravenous dose of anrikefon, given near the end of kidney stone removal surgery, can reduce opioid-related side effects such as nausea, vomiting, itching, oversedation, and breathing problems in the first 24 hours after surgery. All 160 adult p…

This study tests three common pain relievers (ibuprofen, paracetamol, and tenoxicam) against a placebo to see which works best during shock wave treatment for kidney stones. About 160 adults will rate their pain at several points during the procedure. The goal is to find the safe…

This trial tests whether adding a traditional Chinese herbal decoction, Bushen Huoxue Simiao Formula, to standard care can ease urinary symptoms and improve quality of life for adults recovering from upper urinary tract stone surgery. Participants, aged 18 to 80, will receive eit…

This study compares two ways to break up kidney stones using a laser and a suction device. One method turns stones into dust, the other into small fragments. The goal is to see which leaves fewer stone pieces behind after one month. About 86 adults with small kidney stones will t…

This study tests whether a combination of two drugs, dexmedetomidine and ketamine, can replace opioids for pain control during kidney stone surgery. Sixty adults undergoing the procedure will receive either the opioid-free combo or standard fentanyl-based anesthesia. Researchers …

This study will compare two ways to position patients during surgery to remove large kidney stones. One group will lie on their back (supine), the other on their stomach (prone). Researchers want to see which position leads to fewer complications, less pain, and lower costs. The …

This study tests whether combining traditional Chinese five-element music therapy with herbal acupoint patches can reduce pain and anxiety in people undergoing kidney stone surgery under local anesthesia. Sixty adults with small kidney stones will be randomly assigned to receive …

This trial will compare two techniques for removing kidney stones larger than 2 cm: a flexible suction sheath (FANS) and direct suction through the scope (DISS). About 100 adults will be randomly assigned to one method. The study will measure surgery time, how completely stones a…

This study compares lidocaine, a numbing drug, to morphine for treating severe kidney stone pain in the emergency room. Researchers will enroll 250 adults whose pain isn't relieved by standard treatment. The goal is to see if lidocaine provides better pain relief at 30 minutes, p…

This study compares two common procedures—RIRS (a scope through the urinary tract) and ESWL (shock waves from outside the body)—to see which removes small kidney stones (up to 1.5 cm) in the lower part of the kidney more effectively. About 66 adults aged 18 to 60 with these stone…

This study compares two new suction-based tools (FANS and CVAC) for removing medium-to-large kidney stones. About 159 adults with stones 8-20 mm will be randomly assigned to one device. The goal is to see which scope clears more stones completely, as shown on CT scans.

This study will compare two types of lasers used to break up kidney stones during a procedure called ureteroscopy. About 70 adults with a single kidney stone or multiple stones totaling 7-20 mm will be randomly assigned to receive either a pulsed Thulium:YAG laser or a pulse-modu…

This study compares a new ureteral access sheath with built-in suction (FANS) to the standard sheath used during kidney stone removal surgery. The goal is to see if the suction device helps clear more stone fragments and reduces infections. About 134 adults with kidney stones wil…

This study compares two nerve block techniques—dual external oblique fascial plane block and erector spinae plane block—for pain control after percutaneous nephrolithotomy (PCNL), a surgery to remove large kidney stones. Ninety adults will be randomly assigned to receive one of t…

This study looks at different ways to manage pain after a type of kidney stone surgery called PCNL. Researchers will track how much opioid pain medicine patients need and their pain levels. The goal is to find which method works best to reduce pain and limit opioid use.

This study tests a new robotic system called LARC that helps surgeons precisely guide a needle into the kidney during surgery for large kidney stones. The goal is to make the procedure safer and faster by reducing the need for a separate pre-surgery step. Up to 45 adults will be …

This pilot study tests a patient navigation program for people who visited the ER for kidney stones and are at risk of missing their follow-up urology appointment. About 31 participants will get a trained navigator who helps with scheduling, transportation, and other barriers for…

This study looks at whether the type of anesthesia used during a common kidney stone procedure affects how much effort the surgeon feels they are putting in. Researchers will observe adults having flexible ureteroscopy and retrograde intrarenal surgery (RIRS), where the anesthesi…

This study tests whether a scoring tool called a nomogram can accurately predict if a patient will be completely stone-free after a minimally invasive kidney stone surgery called flexible ureterorenoscopy. Researchers will compare the nomogram's predictions with actual surgical o…

This study will test whether taking apple cider vinegar every day for a short time changes the chemistry of urine in adults, both those with a history of calcium oxalate kidney stones and healthy volunteers. Researchers will measure levels of citrate, pH, calcium, and calcium oxa…

This study will compare two types of tubes (ureteral access sheaths) used during kidney stone surgery to see if one causes less kidney damage. Sixty adults with kidney stones will be randomly assigned to get either the standard tube or a new aspiration-assisted tube. Doctors will…

This study will test a special AI program called UroMed AI Doctor, designed to help with urology care. Researchers will compare AI-assisted care to traditional care from a specialist for patients with kidney stones, enlarged prostate, or bladder cancer. The goal is to see if the …

This study compares over-the-counter and prescription alkalinizing agents to see how well they change urine chemistry and reduce kidney stone risk. Fifteen adults with or without a history of stones will follow a strict diet and take different medications. The goal is to find eff…

This study will compare gut bacteria and blood markers between 270 kidney stone patients and healthy people in Shanghai. Researchers want to see if hot, humid weather changes gut microbes and tryptophan metabolism in ways that promote stone formation. No treatment is given; the g…

This study looks at whether having one or two faulty copies of the CYP24A1 gene makes kidney stones more likely. Researchers will compare people with different gene variants to see how often stones occur. The goal is to better understand the genetic factors behind this common and…