Narcolepsy

This trial tests an experimental oral drug, TAK-861, in people with narcolepsy type 1, a condition that causes severe daytime sleepiness and sudden muscle weakness (cataplexy). Researchers will compare TAK-861 against a placebo to see if it improves alertness and reduces cataplex…

This trial tests whether a low-sodium form of oxybate, called XYWAV, can reduce daytime sleepiness and improve daily function in adults aged 18 to 75 with idiopathic hypersomnia or narcolepsy. Participants take the oral solution at night, with doses adjusted to their needs, and r…

This study tests whether clarithromycin, an antibiotic, can reduce excessive daytime sleepiness in people with narcolepsy or idiopathic hypersomnia. Participants receive either clarithromycin or a placebo for 14 days. Researchers will measure changes in sleepiness, brain activity…

This study involved 155 adults with narcolepsy who were already taking a high-sodium oxybate medication. They switched to Xywav, a low-sodium version, to see if their blood pressure would improve. The goal was to provide doctors and patients with useful information about the impa…

This study explores whether a three-dimensional electronic pulse diagnostic device can accurately identify Traditional Chinese Medicine (TCM) syndromes in people with sleep disorders. Participants undergo pulse measurements and symptom assessments, and the device's results are co…

This study compares a new mass spectrometry technique to the standard radioimmunoassay for measuring orexin-A levels in cerebrospinal fluid. Orexin-A is a key brain chemical that is low in people with type 1 narcolepsy. The study involves 117 people with excessive daytime sleepin…

This study tested a headband called Dreem 3S that people wear at home to monitor sleep and wake patterns. The goal was to see if it can help diagnose narcolepsy, a condition that causes extreme daytime sleepiness. 78 adults took part, and researchers checked how well the device w…

This trial tests whether a nurse-led program of sleep hygiene education and progressive muscle relaxation can improve sleep quality in obese pregnant women. Researchers will enroll 100 women in their third trimester with a BMI of 30 or higher and sleep problems. Half will receive…

This trial tests whether a daily sleep gummy can improve sleep quality and quantity in adults aged 20-50 who have self-reported sleep issues. Participants take one gummy before bed for 7 days while wearing a Fitbit tracker to measure sleep patterns. The study compares sleep metri…

This trial tests whether different combinations of cannabinoids—THC, CBN, CBG, CBD, and melatonin—taken as gummies can improve sleep quality in adults aged 21 to 55 who report poor sleep. Participants will be randomly assigned to receive one of several active gummy formulas or a …

This trial tests whether a set of EMF protection devices—including pads, chips, and bands—can improve sleep quality and energy levels in adults aged 30-60 who have trouble sleeping. Participants use all devices daily for about four weeks while tracking sleep with a wearable ring …

This study tests whether personalized advice on sleep timing, light exposure, meal times, and physical activity can improve sleep quality in adults aged 65 and older who have poor sleep. Participants are randomly assigned to receive either general sleep advice or a customized pla…

This study tested an experimental drug called TAK-861 in 105 adults with narcolepsy type 1, a condition causing severe daytime sleepiness and sudden muscle weakness (cataplexy). Participants took either TAK-861 or a placebo daily for 3 months. The main goal was to see if the drug…

This study tests two behavioral therapies—imagery rehearsal therapy (IRT) and targeted dream control (TDC)—to reduce nightmares in adults with narcolepsy. Participants attend therapy sessions, keep a daily sleep log, and complete questionnaires. Some Chicago-area participants als…

This Phase 2 trial tested AXS-12 (reboxetine) in 21 adults with narcolepsy and cataplexy. Participants received either the drug or a placebo for three weeks, then switched. The goal was to see if AXS-12 could reduce weekly cataplexy attacks and improve excessive daytime sleepines…

This study tested a new medicine called ALKS 2680 in 92 adults with narcolepsy type 1, a condition that causes severe daytime sleepiness and sudden muscle weakness (cataplexy). Participants stopped their usual narcolepsy medications and received either ALKS 2680 or a placebo for …

This study tested a six-session behavioral therapy that teaches people with narcolepsy type 1 how to become aware during dreams (lucid dreaming) and control frightening images. Ninety-eight adults took part, with half receiving the therapy and half getting standard care. The goal…

This study tested an experimental drug called AXS-12 (reboxetine) in 90 people with narcolepsy who experience cataplexy (sudden muscle weakness) and excessive daytime sleepiness. Participants took either the drug or a placebo twice daily for several weeks. The main goal was to se…

This study tested a dietary supplement called Speed Sleep in 60 adults aged 18-65 who have trouble sleeping. Participants took either the supplement or a placebo daily for 4 weeks. Sleep quality and quantity were measured using Fitbit trackers and questionnaires.

This study tested whether a daily mix of plant protein and two herbs (ashwagandha and rhodiola) could improve sleep in 100 adults aged 35-70 with sleep troubles. Participants took either the supplement or a placebo for 30 days and reported their sleep quality daily. The goal was …

This phase 2 study tested an experimental drug called ALKS 2680 in 93 adults with narcolepsy type 2, a condition causing severe daytime sleepiness. Participants took either the drug or a placebo daily to see if it safely improved their ability to stay awake. The trial is now comp…

This early study tested a product called Chenghuang Circadian Rhythm Regulator in 15 adults with ongoing sleep problems. The goal was to see if it could improve sleep quality and immune markers. Results are not yet reported, but the study was small and had no comparison group.

This study followed 71 adults with narcolepsy who started taking LUMRYZ, a medication for excessive daytime sleepiness. Over 4 months, participants filled out questionnaires about their symptoms, how they felt about the drug, and their quality of life. The goal was to see if LUMR…

This study tested whether a headband called Muse-S, which senses brain activity, could help midlife women with sleep problems like insomnia. Thirty-one women going through menopause wore the device at home. The goal was to see if it was practical and if it improved sleep quality …

This study tested whether acupressure—a gentle finger-pressure technique on specific body points—could improve sleep in elderly people living in care homes. 75 residents took part, with half receiving 12 acupressure sessions over four weeks. The results showed that those who rece…

This study tested an online program called ALDER that teaches older adults skills to boost positive emotions and reduce anxiety. 33 people aged 65 and older who used benzodiazepines (anti-anxiety or sleep medications) at least twice a week took part. Over 5 weeks, they learned an…

This early-phase study tested a new slow-release form of pitolisant (HBS-201) in 46 adults with narcolepsy. The goal was to see if starting at a full dose is tolerable. Participants took the drug for 14 days, and researchers tracked side effects and dropouts.

This study looked at the long-term safety and effectiveness of a drug called AXS-12 for people with narcolepsy who also have sudden muscle weakness (cataplexy) and severe daytime sleepiness. 68 people who had already completed an earlier study took AXS-12 and were monitored for s…

This study tested a sleep and circadian treatment (TranS-C) for people with severe mental illness (SMI) in community mental health centers. The treatment was adapted to better fit these settings. Researchers looked at whether it improved sleep, daily functioning, and symptoms in …

This study tested two versions of a sleep treatment for people with severe mental illness in community mental health centers. One version was the standard treatment, and the other was adapted to better fit patients' needs. The goal was to see if training clinic staff to deliver t…

This study tested a new once-nightly medication called FT218 for people with narcolepsy who experience excessive daytime sleepiness and sudden muscle weakness (cataplexy). It included 184 participants, some already on a twice-nightly medication and some new to treatment. The goal…

Idiopathic hypersomnia causes severe daytime sleepiness that differs from narcolepsy, yet researchers do not know what drives it. This study uses 64-electrode EEG to look for local slow waves, a sign of sleep-like activity in parts of an otherwise awake brain, while participants …

This study looked at 103 adults with narcolepsy or obstructive sleep apnea to see if anxiety, social, or work factors affect their ability to stay awake during a standard test. Participants filled out an anxiety questionnaire before the test. The goal is to better understand why …

This study looked at how the drug modafinil affects driving ability in 27 people with narcolepsy or hypersomnia. Participants took modafinil or a placebo for five days, then completed both simulated and real driving tests. The goal was to see if the drug improves alertness and re…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…

This study tested a website designed to help teenagers with narcolepsy or idiopathic hypersomnia and their families understand and improve social relationships. Twenty-five teens and their parents reviewed the website's content, which included animations, patient stories, and exp…

This study looked at 24 children (ages 6-17) with narcolepsy or hypersomnia to see if changes in their metabolism explain why they often gain weight and become obese. Researchers measured energy use at home and in the hospital using activity trackers. The goal was to understand t…