Myocardial ischemia

This study tests whether using a special camera (OCT) inside the heart's arteries during a heart attack procedure leads to better outcomes than the standard X-ray method. About 3000 people having a heart attack will be randomly assigned to one of the two approaches. The goal is t…

This study tests whether a temporary heart pump can help high-risk patients during coronary stenting. The pump supports the heart's main chamber during the procedure, aiming to prevent heart failure or death. About 300 patients with severe coronary disease and weak heart muscle w…

This study tests whether using the Impella heart pump during a high-risk stenting procedure helps people with weak hearts and blocked arteries. About 1,250 participants will be randomly assigned to get either Impella-supported stenting or standard care. The goal is to see if the …

This study evaluates a special balloon coated with sirolimus, a drug that helps prevent arteries from narrowing again after angioplasty. The balloon is used during routine procedures to open blocked heart arteries in people with coronary artery disease. Researchers are tracking h…

This study looks at 600 people who had a major heart attack and have other narrowings in their heart arteries that are not severe but look unstable. Half will get a stent plus medication, and half will get medication alone. The goal is to see if stenting these unstable plaques re…

This study monitors the safety and performance of a medical device called Sequent Please Neo, used to treat blocked heart arteries. About 2,028 people receiving the device as part of their routine care will be followed. Researchers will track major heart problems like heart attac…

This trial tests whether using a special camera inside the arteries (optical coherence tomography, or OCT) is better than standard pressure-wire measurements for deciding which non-blocked arteries need stenting in people who have just had a heart attack. About 1,425 participants…

This study follows about 3000 people with complex coronary artery disease who receive the Ultimaster Nagomi stent, a device that slowly releases a drug to keep arteries open. The goal is to see how often the stent fails—meaning heart-related death, heart attack, or need for anoth…

This study compares a new type of heart stent called Freesolve, which is made of magnesium and dissolves over time, to a standard permanent metal stent. About 1,859 people with coronary artery disease will receive one of the two stents. The goal is to see if the dissolving stent …

This early study tests a new stent system designed to treat blockages at artery branch points in the heart. It involves 13 people with heart disease who need a procedure to open these blockages. The main goal is to see if the stent can be safely placed and work as intended.

This trial studies nearly 1,000 people with severe aortic stenosis and blocked coronary arteries who need both a valve replacement (TAVI) and artery stenting (PCI). Researchers want to see if doing the stenting before or after the valve replacement leads to fewer deaths, heart at…

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approac…

This study tests a new device called the Acolyte Catheter System in people with completely blocked heart arteries (chronic total occlusions) who still have symptoms despite medication. The goal is to see if the catheter can safely help doctors guide wires through the blockage to …

This study tests whether using a special imaging tool called OCT during stent placement leads to fewer heart problems over two years compared to standard methods. About 1,200 adults with blocked heart arteries that need complex stenting are taking part. The goal is to see if OCT …

This study tests whether briefly inflating a blood-pressure cuff on the arm before non-cardiac surgery can reduce heart damage in high-risk patients. Over 1,200 participants will receive either the cuff procedure or no intervention. The goal is to see if this simple, low-cost tec…

This study tests a smartphone app called MED-AD that sends reminders and tracks medication use for people with heart disease, high blood pressure, or high cholesterol. About 1,000 adults in Oman will be randomly assigned to use the app, receive daily text reminders, or get usual …

This study tests a newer drug-coated stent (Resolute Onyx) against an older one (Resolute Integrity) in 550 people with blocked heart arteries in China. The goal is to see if the new stent works better at keeping arteries open after angioplasty. Participants receive one of the tw…

This study tests a special stent coated with a drug called zotarolimus to treat people with blocked heart arteries. The stent is placed during a procedure to open the artery and slowly releases medication to prevent re-blockage. About 591 participants in China are being followed …

This trial tests whether a procedure called catheter ablation works better than anti-arrhythmic drugs for people with structural heart disease who have had a dangerous fast heart rhythm (ventricular tachycardia). About 162 participants will be randomly assigned to either ablation…

This study looks at whether people with stable ischemic heart disease (but with normal heart pumping function and no ongoing chest pain or arrhythmias) can safely stop taking beta-blockers. About 59 participants will either continue or stop their beta-blocker and be followed for …

This study is tracking 251 patients with symptomatic coronary heart disease who received the EucaLimus stent, a sirolimus-coated device designed to keep arteries open. The goal is to see how well the stent works and how safe it is over the long term in real-world use. Researchers…

This study compares two types of stents (small mesh tubes) used to open blocked heart arteries in people with severe three-vessel coronary artery disease. About 1,550 participants will receive either the SUPRAFLEX Cruz or SYNERGY stent. The goal is to see which stent is safer and…

This study tests a program that combines a mobile health app, community health workers, and text message reminders to help people lower their risk of heart disease. About 968 adults in Argentina who are at high risk will take part. The goal is to see if this approach can improve …

This study is tracking 400 people with coronary artery disease who received the ihtDEStiny drug-eluting stent during a routine procedure to open blocked heart arteries. Researchers are monitoring how well the stent works over time, including rates of heart attacks, repeat procedu…

This study is tracking 282 patients with coronary artery disease who received a paclitaxel-coated balloon catheter (Support C DCB) during routine care. Researchers are monitoring for heart-related events like cardiac death, heart attack, or the need for repeat procedures over the…

This study tests a new health management program for people with coronary heart disease who also have frailty (weakness, low energy). The program uses a mobile app to guide exercise and healthy habits, with support from a cardiac rehab center. Researchers will enroll 200 particip…

This trial tests whether injecting a patient's own bone marrow stem cells into the heart can improve exercise ability and reduce chest pain in people with severe, untreatable angina. About 343 participants will either receive the stem cell treatment or a sham procedure. The goal …

This study was designed to test the safety of a gene therapy called VM202 in people with chronic refractory myocardial ischemia—severe chest pain that doesn't improve with standard treatments. The therapy would be injected directly into the heart via a catheter. However, the tria…

This study aimed to test a gene therapy called VM202RY in people who recently had a heart attack. The treatment was injected directly into the heart muscle to help it heal and improve pumping strength. However, the trial was withdrawn before enrolling any participants, so no data…

This early-phase trial is testing whether heart muscle cells grown from stem cells can be safely injected into the hearts of 10 people with severe heart failure caused by blocked arteries. The main goal is to check for side effects over 26 weeks, while also measuring whether the …

This study tests whether ivabradine, a drug that slows heart rate, can prevent heart injury after noncardiac surgery. About 2,100 high-risk patients aged 45 and older will receive either ivabradine or a placebo before and after surgery. The goal is to see if the drug reduces hear…

Researchers compare two types of CT scanners for imaging heart arteries in people with suspected chronic coronary syndrome. One scanner uses standard energy-integrating detectors, while the other uses newer photon-counting detectors that may produce clearer pictures with fewer fa…

This study is testing a new way to diagnose blocked heart arteries using an ultrasound-based method called Ultrasonic Flow Ratio (UFR). It involves 112 people with suspected heart disease. The goal is to see if UFR can accurately identify significant blockages compared to the cur…

This large UK study (EVAREST) aims to improve how doctors interpret stress echocardiograms for diagnosing coronary artery disease. Researchers will collect blood samples and analyze echocardiogram images from up to 23,000 patients to find new biomarkers that make diagnosis more a…

This study tests a new PET heart scan that uses 100 times less radiation than current methods. Researchers will scan 200 adults with known or suspected heart artery disease to see if the ultra-low dose still produces clear images. The goal is to make heart imaging safer while kee…

This study tests whether personalized risk models can safely reduce the number of diagnostic tests for people with new chest pain. Researchers will enroll 2,000 adults aged 30-75 and compare the model-based approach to standard care. They will also test a new laser method to meas…

This study tests a new way to classify heart attacks based on whether a coronary artery is fully blocked (occlusion) or not, instead of the traditional ST-elevation vs non-ST-elevation method. Researchers will compare outcomes in 6,000 patients to see if the new approach leads to…

This trial compares three common heart-rate-lowering drugs—metoprolol, atenolol, and ivabradine—to see which one reduces heart rate fastest before a cardiac CT scan. About 350 adults aged 30–80 with a heart rate over 65 beats per minute will receive one of the drugs or a placebo.…

This study is testing whether a wearable ECG patch, combined with AI analysis, can help doctors identify a wide range of heart conditions and risks from a single recording. The Cor360 system looks at many aspects of heart health at once, such as heart failure, rhythm problems, an…

This study looks at 90 people who recently had a heart attack and have other artery narrowings that may or may not be dangerous. Researchers will use two types of scans—optical coherence tomography (OCT) and magnetic resonance angiography (MRA)—to see if they can tell which narro…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study reviewed medical records of 1000 people who received a special balloon treatment (drug-coated balloon angioplasty) for blocked heart arteries between 2009 and 2015. Researchers tracked major heart problems like death, heart attacks, or need for repeat procedures for up…

This study uses advanced CT scans to look for fat and scar tissue inside the heart. Researchers want to see if these findings can help predict who is at risk for dangerous heart rhythms. About 110 adults with heart disease who already have a defibrillator or need one will get a C…

This study looks at whether adding a stress CT scan that checks blood flow to the heart muscle helps doctors decide the best treatment for people with known or suspected heart disease. About 2000 adults will be followed to see if this extra test reduces the need for more tests an…

This study follows 500 people with peripheral artery disease (PAD) who undergo a procedure to open blocked leg arteries. Researchers check blood and heart ultrasound before and after the procedure to find hidden heart injury. The goal is to see if certain markers can predict futu…

This study looks at whether giving a personalized dose of a radioactive tracer (rubidium-82) based on a patient's weight can improve the quality of PET heart scans. Researchers will enroll 48 adults with known or suspected heart disease and divide them into four weight groups. Th…

This study follows nearly 20,000 patients who had major non-cardiac surgery to see how often heart injury occurs and what happens a year later. Researchers are looking at death rates and major heart complications. The goal is to better understand who is at risk and how to improve…

This study looks at whether a computer model can predict heart injury after major orthopedic surgery in patients 65 and older. Researchers will combine blood tests, frailty scores, and other health data to build a machine learning tool. The goal is to help doctors spot high-risk …

This study looks at whether a specific type of heart stent (zotarolimus-eluting) can be expanded more than usual to treat tricky blockages. Researchers will use a special camera (OCT) to check the stent's size and safety in 30 adults with coronary artery disease. The goal is to s…

This study observes how doctors use a special imaging technique called OCT during heart stent procedures in routine care. Researchers will track 2,000 patients with heart artery blockages to see if using the MLD-MAX algorithm helps achieve better stent placement. The goal is to u…

This study looks at whether artificial intelligence can improve predictions of serious heart events in people with chest pain. Researchers will analyze stress echocardiogram results and routine medical data from about 2,281 adults. No extra visits or tests are needed for particip…

This study is a registry that follows over 1,000 people with suspected ischemic heart disease. Doctors use special tests during heart catheterization to measure blood flow and pressure in the heart's small vessels. The goal is to see if these measurements can predict future heart…

This study tracks how doctors in Spain use injectable blood thinners (cangrelor or GPIs) during heart procedures like stent placement. It includes 717 patients and will look at short-term outcomes like death, heart attack, stroke, and bleeding within 48 hours. The goal is to unde…

This study follows over 5,000 people with stable heart disease who were previously treated with either an invasive strategy (like stents or bypass surgery) plus medication, or medication alone. Researchers want to see which approach leads to better survival over 10 years. The goa…

This study looks at whether routine screening for heart disease is a good use of healthcare money for people with type 2 diabetes who are at very high risk but have no known heart problems. Researchers will analyze data from 90,000 patients in French health databases to compare c…

This study is collecting information from 500 people who had a first heart attack and received a cardiac MRI. The goal is to see if MRI images of the heart can help predict who will have future heart problems like heart failure or need a heart transplant. Researchers are looking …

This study involves 500 people who have chest pain or other signs of heart trouble, but whose main heart arteries are not blocked. Researchers use special tools during a heart catheterization to measure tiny blood vessel function and look for hidden causes like microvascular dise…

This study looks at why some women with chest pain or signs of heart disease have normal-looking large arteries but still have problems with tiny blood vessels in the heart. Researchers will measure platelet activity and inflammation during a heart catheterization to see if these…

This study looks at three ways to treat severely hardened heart arteries before placing a stent: using sound waves (lithotripsy), a high-pressure balloon, or a tiny rotating device (orbital atherectomy). The goal is to see how each method affects the small blood vessels in the he…

This study looks back at over 5,500 people with known or suspected heart disease who had a stress heart MRI. Researchers want to see if the MRI results can predict who is at higher risk of dying over many years. The goal is to help doctors better understand test results and guide…

This study looks back at medical records of 1,000 people who had a special test during a heart catheterization to measure blood flow in their heart arteries. Researchers want to see if the test results can predict future heart attacks, the need for another procedure, or death fro…

This study compares specially trained nurses to interventional cardiologists in performing radial catheterization for elective coronary angiography. Over 1,600 participants will be randomly assigned to have the procedure done by a nurse or a cardiologist. The goal is to see if nu…

This study was designed to see if helping heart patients with social problems like food, housing, and mental health could keep them out of the hospital. The researchers planned to screen patients and connect them to community resources. However, the study was withdrawn before enr…