Musculoskeletal system disorder

This study tests whether adding a patient's own concentrated bone marrow cells to a standard hip surgery (core decompression) can prevent the hip ball from collapsing and delay or avoid the need for a hip replacement. It includes 192 adults with early-stage osteonecrosis (before …

This study tests an experimental drug called AOC 1044 for boys with Duchenne muscular dystrophy (DMD) who have a specific genetic change (exon 44 skipping). About 70 boys aged 7 to 16 who can still walk will receive either the drug or a placebo. The main goal is to see if the dru…

This Phase 1 trial tests the safety and tolerability of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive one or two doses under the skin and are monitored for side effects and how the drug moves through the body. The study…

This program provides access to an experimental drug, AOC 1044, for people with Duchenne muscular dystrophy (DMD) whose genetic mutation can be treated by skipping exon 44. The goal is to help control the disease and improve muscle function. Participants must be at least 2 years …

This trial tests a computer-assisted reintegration protocol for employees on sick leave due to musculoskeletal disorders, such as back, neck, or shoulder pain. The protocol helps occupational health professionals follow national guidelines and Dutch law when guiding employees bac…

This study tests vosoritide, a protein that stimulates bone growth, in 30 children with Noonan syndrome who are not growing well despite growth hormone treatment. The goal is to see if vosoritide can safely increase their growth rate over six months. Participants will receive one…

This study tests a new medicine called BMN 333 against an existing drug (vosoritide) to see if it can safely improve growth in children with achondroplasia, the most common form of dwarfism. About 160 children aged 2 to 17 will take part. The goal is to measure how much they grow…

This trial tests whether transferring gut bacteria from a healthy donor (fecal microbiota transplantation, or FMT) can reduce disease activity in people with axial spondyloarthritis (axSpA) who haven't fully responded to biologic therapy. Participants receive a single enema with …

This Phase 3 trial tests whether a lab-grown cartilage implant (MACI) can better repair painful ankle cartilage defects than the standard microfracture procedure. About 309 adults aged 17-65 with ankle cartilage damage will be randomly assigned to receive either MACI or microfrac…

This early-stage study tests a new treatment made from healthy donor immune cells (CAR T cells) for people with severe autoimmune diseases like lupus that haven't responded to standard therapies. The goal is to see if these cells can safely target and calm the overactive immune s…

This study tests an oral drug called infigratinib in infants and children under 3 years old with achondroplasia, the most common form of dwarfism. The goal is to see if it safely improves growth and body proportions. The trial has several phases to find the right dose and then co…

This study compares two types of wrist fusion surgery for people with post-traumatic wrist arthritis. One surgery fuses four wrist bones and removes the scaphoid. The other fuses three or two bones and also removes the triquetrum. The goal is to see which approach gives better gr…

This study compares two common tendon grafts used in ACL knee reconstruction: the quadriceps tendon and the patellar tendon. Researchers want to see which one gives better knee stability and function after surgery. The trial will enroll 100 people who need ACL surgery and follow …

This study is testing a drug called olokizumab in children aged 2 to 18 with active juvenile idiopathic arthritis. The drug is given as a shot under the skin every 4 weeks. Researchers want to see how the drug moves through the body, if it helps control arthritis symptoms, and if…

This study is testing the long-term safety of an experimental drug called PGN-EDODM1 in 48 adults with myotonic dystrophy type 1 (DM1) who have already taken the drug in a previous study. Participants will receive the drug by IV infusion and be monitored for side effects. The goa…

This study tests whether giving tranexamic acid (TXA) during hip reconstruction in children reduces blood loss and the need for blood transfusions. About 400 children will be randomly assigned to receive TXA, a nerve block, or standard care. The goal is to make surgery safer and …

This study tests a new drug called KK8123 for adults with X-linked hypophosphatemia (XLH), a rare genetic condition that causes low phosphate levels and bone problems. The trial has two parts: first, finding the right dose, then checking safety and how well it works over time. Ab…

Researchers are building AI models that score standard physical and cognitive screening tests from video and audio, and that predict results a person did not obtain. The study enrolls adults 18 and older and follows them for life, linking records to a long-term aging study to che…

This study aims to develop a faster and more consistent MRI method to detect early signs of osteoarthritis and other joint problems. Researchers will scan 88 healthy volunteers and patients with ACL tears using MRI machines from different manufacturers. The goal is to create a st…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

Researchers are testing whether people can put full weight on the foot immediately after a modified Lapidus operation, a common bunion surgery that fuses bones in the midfoot. The trial assigns 122 adults to either walk fully in a special post-op shoe or limit weight to 10 to 15 …

This study tests a once-daily pill called orforglipron in 800 adults with obesity or overweight who also have painful knee osteoarthritis. The goal is to see if the drug reduces knee pain and improves physical function over about 74 weeks. Participants will be randomly assigned t…

This study tests three group-based psychological treatments—Cognitive-Behavioral Therapy, Emotional Awareness and Expression Therapy, and Mindfulness Meditation—delivered over video to older veterans (ages 60-95) with chronic musculoskeletal pain. The goal is to see which therapy…

This study tests a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) for veterans with chronic musculoskeletal pain. EAET helps people understand and express emotions linked to past stress or trauma, which may reduce pain. Researchers will train therap…

This study tests whether adding a steroid to the standard pain injection during total knee replacement improves pain control and reduces the need for opioid painkillers. 240 adults undergoing knee replacement will be randomly assigned to receive either the standard injection, one…

This study tests whether adding dry needling to standard physical therapy helps people with jaw pain (TMJ dysfunction). One hundred adults will either get standard rehab alone or rehab plus dry needling. Researchers will measure pain, jaw movement, and quality of life to see if t…

This study tests whether a 12-week home-based shoulder strength training program can reduce pain and improve function in manual wheelchair users with spinal cord injury. Forty participants will start training either 3 or 12 months after leaving rehab. Researchers will track pain,…

This study tests whether adding virtual reality (VR) exercises to standard physical therapy can improve hand function, reduce pain, and speed recovery in adults with traumatic wrist or hand injuries. About 40 participants will receive either usual rehab alone or usual rehab plus …

This study looks at whether adding a nerve block to a standard steroid injection helps people with frozen shoulder feel less pain and move better. About 110 adults with frozen shoulder will get either the combo treatment or a steroid injection alone. The goal is to see if the ner…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether personalized health coaching can reduce chronic muscle and joint pain in people aged 60 and older. 268 participants will either receive four face-to-face coaching sessions focused on exercise, diet, stress, sleep, social support, and avoiding risky substa…

This study compares two hands-on treatments—Mulligan mobilization and myofascial release—for people with cervicogenic headache (headache caused by neck problems). 90 adults aged 18-65 who have had neck pain or headache for at least 3 months will track their headache frequency, pa…

This study tests a web-based program called Web-TIRELESS that teaches mind-body skills to help people with painful non-traumatic upper-extremity conditions and risky substance use. The program includes four 30-minute sessions covering cognitive-behavioral strategies, activity pac…

This study compares two treatments for carpal tunnel syndrome: an ultrasound-guided injection around the nerve versus a small-incision surgery to relieve pressure. Researchers will measure pain and hand function in 60 adults with mild to severe symptoms over 12 weeks. The goal is…

This study tests whether a type of exercise called diagonal proprioceptive neuromuscular facilitation (PNF) can reduce pain and improve function in people with knee osteoarthritis. Researchers will compare PNF exercises to standard strength training in 150 adults aged 40-60. Both…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests a new treatment for heel pain caused by plantar fasciitis. Tiny, dissolvable beads are injected to block blood flow to the painful area. The goal is to see if this procedure safely reduces pain better than standard care. About 45 adults with chronic heel pain wil…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This pilot study tests whether combining group art therapy with exercise can help older adults (60+) who have had low back pain for at least three months. The study will enroll 30 participants to see if the program is feasible and acceptable, and to gather early signs of whether …

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study watches children aged 2.5 to 17 with hypochondroplasia, a condition causing short stature, to track their growth and health over time. No treatments or drugs are given. The goal is to learn more about how the condition affects growth, body proportions, thinking skills,…

This study measures the physical forces and muscle strain experienced by gastroenterologists while performing ERCP, a complex endoscopic procedure. Ten doctors will be recorded using motion-capture technology during ERCP and standard endoscopies. The goal is to identify ergonomic…

This study follows 300 adults with systemic lupus erythematosus (SLE) who are seen by a team of specialists at a hospital in Brest, France. Researchers will collect data on disease patterns, symptoms, and test results over time. The goal is to better understand lupus and improve …

This study looks at whether starting physical therapy 2 weeks after reverse total shoulder replacement (for a broken upper arm bone) is better than waiting 6 weeks. Ten adults aged 50-85 will be randomly assigned to one of the two rehab schedules. The goal is to see which timing …

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study looks at how endurance exercise (like walking or cycling) and resistance exercise (like lifting weights) affect bone health in older veterans aged 60 and over. Researchers want to see if either type of exercise causes bone breakdown and how the body adapts over time. T…

This study is testing a screening tool called Start-MSK that helps physiotherapists sort people with muscle or joint pain into low, medium, or high risk for long-term problems. Researchers will follow 300 adults for 6 months to see if the tool can predict who will recover well an…

This study looks at how the shoulder blade moves and muscles work in violin and viola players who have neck pain compared to those who don't. Researchers will measure muscle activity and shoulder position while players lift their arms and perform musical tasks. The goal is to fin…

This study looks at whether a doctor's computer tool (MedSafer) and patient brochures (EMPOWER) can help reduce the use of potentially harmful medications in adults aged 60 and older with rheumatic diseases who take five or more regular drugs. Researchers will follow 100 particip…

This study surveys 90 dentists and dental specialists to find out how common muscle and bone pain is in their job. Participants fill out a questionnaire about pain in different body areas and their knowledge of ergonomics. The goal is to identify which body parts are most affecte…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study aims to uncover the genetic causes of hereditary spastic paraplegia (HSP), a group of rare neurological diseases that cause progressive muscle stiffness and weakness. Researchers at Boston Children's Hospital will analyze DNA from 200 people with HSP to find genetic va…

This study looks at how carpal tunnel syndrome (CTS) severity relates to sleep quality. Researchers will compare 120 CTS patients with healthy controls using ultrasound and sleep questionnaires. The goal is to better understand the connection between nerve compression and poor sl…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study is observing 40 people with osteogenesis imperfecta (brittle bone disease) to see how often heart problems occur. Researchers will use standard heart tests like echocardiograms to check for issues. The goal is to create better screening guidelines to catch heart proble…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is an online survey for 1,000 adults diagnosed with a rheumatic or musculoskeletal disease living in a EULAR country. Participants will answer periodic questionnaires about their healthcare, social life, and work. The goal is to gather real-world data to help researche…

This study tests whether text messaging can help collect feedback from orthopedic patients about their recovery. Researchers will enroll up to 3,000 people with specific bone or spine injuries. The goal is to use this information to schedule clinic visits more efficiently, so pat…

This study is a registry that collects information on how well the CERAMENT bone void filler works in everyday medical practice. About 300 people receiving the filler during surgery will be followed for up to 18 months. The goal is to track any unexpected device issues, side effe…

This study follows 100 people who had total ankle replacement for arthritis. Researchers want to see if the implants last 10 years and how well patients do when the surgery is performed by surgeons who did not design the implant. Participants will have regular check-ups, X-rays, …

This study looks at how the size and type of rotator cuff tear affects the suprascapular nerve in the shoulder. Researchers will use MRI scans and nerve tests on 250 adults to see which tears cause nerve damage. They also want to find out if surgical repair can help the nerve rec…