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Knee surgery showdown: which tendon graft works best?

NCT ID NCT05461326

Disease control Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two common tendon grafts used in ACL knee reconstruction: the quadriceps tendon and the patellar tendon. Researchers want to see which one gives better knee stability and function after surgery. The trial will enroll 100 people who need ACL surgery and follow their recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
quadriceps tendon autograft or patellar tendon autograft (surgical procedure)
What this could lead to
If one graft proves clearly better, it could become the preferred choice for ACL reconstruction, leading to more stable knees and better recovery for patients.
What could go wrong
This is a relatively small, early-stage trial (100 people) comparing two established procedures, so any differences may be small or not apply to everyone. Both grafts have known risks like pain or stiffness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2023

Expected to finish

Jun 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

14 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Skeletally mature patients younger 65 * ACL insufficiency * Scheduled to undergo autograft ACL reconstruction * Appropriate candidate for autograft harvest Exclusion Criteria: * \<14 or 65\> * Poor autograft candidate (poor tissue quality) * Multi ligamentous reconstruction (PCL, MCL, or PLC) * Pregnant or nursing * High likelihood of remaining non-compliant with physical therapy regimen * Desire to return to sport prior to 6 months * Inability to read and write English

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries musculoskeletal system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament injuries Orthopedic disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UAB Hospital Highlands

    RECRUITING

    Birmingham, Alabama, 35205, United States

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