Hypoglycemia

Researchers test whether continuous glucose monitors (CGM) can help hospitalized adults with type 2 diabetes reach a tighter average blood sugar target of 90 to 130 mg/dL without causing dangerous low blood sugar. Participants are randomly assigned to standard care (target 140 to…

This study tests whether choosing diabetes medications based on a person's genetic profile helps control blood sugar better than standard treatment. About 500 adults with type 2 diabetes that is not well controlled will be randomly assigned to either gene-guided or standard care.…

This trial tests a smart insulin pump algorithm designed to automatically adjust insulin delivery during the night to keep blood sugar levels in a safe range. The algorithm predicts when blood sugar might drop too low and pauses insulin, and when it might rise too high, it gives …

This study tests whether treating low blood sugar (hypoglycemia) at a slightly lower threshold of 65 mg/dL, instead of the standard 70 mg/dL, can prevent rebound high blood sugar in children with type 1 diabetes. Each child undergoes both approaches in a crossover design, receivi…

This study investigates whether drinking galactose before cycling can prevent low blood sugar (hypoglycemia) in people with type 1 diabetes. Fourteen participants will try four different drinks—dextrose, galactose, lactose, or a sweetened placebo—on separate days, then cycle for …

This study tested whether transplanting insulin-producing islet cells, along with immune-suppressing drugs, could safely prevent severe low blood sugar episodes in people with type 1 diabetes who don't feel warning signs. Ten participants received the transplant and were monitore…

This study tested whether an enhanced continuous glucose monitor (eCGM) linked to a decision-support system can help older adults (65+) with type 1 diabetes manage their blood sugar. The system automatically uploads glucose, insulin, and activity data to give personalized insulin…

This study tested an artificial pancreas system that learns a person's exercise patterns to prevent low blood sugar (hypoglycemia) during and after moderate exercise. Fifteen adults with type 1 diabetes used the system for about 4 months, comparing it to a standard version. The g…

This study tested a special educational tool for parents of children under 6 with type 1 diabetes. The goal was to see if the tool could help parents better control their child's blood sugar and prevent serious events like low blood sugar or ketosis. The study enrolled 24 childre…

This study tested whether a team of doctors and nurses, guided by an intelligent early-warning system, could reduce low blood sugar (hypoglycemia) in hospitalized adults with type 2 diabetes. Over 1,200 participants received either standard insulin pump therapy or the same therap…

This study tested whether combining two safe immune therapies—abatacept injections and nasal insulin—can help preserve the pancreas's ability to make insulin in people recently diagnosed with type 1 diabetes. The goal is to make blood sugar control easier and reduce the need for …

This study tested whether a real-time continuous glucose monitor could help detect and manage low blood sugar (hypoglycemia) in very low birth weight newborns. 48 infants were randomly assigned to either the continuous monitor or standard finger-stick testing for their first thre…

This study tested whether transplanting insulin-making islet cells could help people with type 1 diabetes who already had a kidney transplant. Fourteen participants received up to three infusions of donor islet cells along with steroid-free immunosuppression. The goal was to see …

This pilot study tested whether high doses of omega-3 fatty acids (fish oil) and vitamin D are safe and can help preserve insulin production in people with type 1 diabetes. The trial included 27 participants, both children and adults, who had diabetes for up to 10 years. Research…

This study looks at whether the weight of the placenta, and its size relative to the baby's birth weight, can help predict low blood sugar (hypoglycemia) in newborns during the first 24 hours after birth. The study will include about 98 infants born at 35 weeks or later to mother…

This study asks whether using a continuous glucose monitor (CGM) — a small sensor worn under the skin that tracks blood sugar levels in real time — can improve quality of life for adults with type 2 diabetes. Participants will use the device for 12 months and complete questionnai…

This study tested a smartphone app called SNAQ that estimates the carbohydrate content of a meal from a single photo. The goal was to see if using the app helps people with type 1 diabetes keep their blood sugar in a healthy range. 44 adults who already use an automated insulin p…

This completed study tested whether a continuous glucose monitor with predictive alerts (Dexcom G7) can reduce low blood sugar better than a standard alert monitor (Dexcom ONE+) in 11 adults with glycogen storage disease or congenital hyperinsulinism. Participants wore each devic…

This study is investigating how often dangerous heart rhythm problems occur in people receiving hemodialysis for end-stage kidney disease. Researchers will implant a small device under the skin to continuously monitor heart rhythm for 18 months in 70 patients, half of whom have d…

Women who become pregnant after weight-loss (bariatric) surgery have a higher chance of delivering smaller-than-expected babies. This study tests whether tracking blood sugar fluctuations with a continuous glucose monitor during each trimester can help predict which babies will b…

This study looks at how often children develop low blood sugar (hypoglycemia) after fasting before anesthesia for elective procedures. Researchers will monitor blood sugar levels in over 6,500 children aged 1 month to 18 years to find a clear definition of hypoglycemia and identi…

This study looked at how the nervous system helps control blood sugar in people with type 1 diabetes who had islet cell transplants. Nine participants received drugs that block nerve signals or a placebo during controlled low blood sugar experiments. The goal was to learn whether…

This completed study looked at why people with type 1 diabetes lose their natural defense against low blood sugar—the hormone glucagon. Researchers tested whether blocking a hormone called GLP-1 with a drug (exendin(9-39)amide) could restore glucagon release during low blood suga…

This study looked at how blood sugar levels change in hospitalized babies with intestinal failure when their intravenous nutrition is given in cycles instead of continuously. Nine infants wore a small sensor on their thigh that measured glucose every 5 minutes for up to 30 days. …

This pilot study tested whether continuous glucose monitors (CGMs) can help manage blood sugar in hospitalized adults with diabetes. Forty patients wore a Dexcom G6 device during their hospital stay to track glucose levels. The goal was to see if CGM could reduce dangerous low or…

This pilot study tested a new program to help prevent low blood sugar (hypoglycemia) in people with diabetes who take medications that can cause it. The program included a patient survey and a toolkit for doctors. The study involved 35 patients and their primary care providers at…

This study looked at whether giving oral glucose at a slightly higher blood sugar threshold can prevent mild-to-moderate hypoglycemia in people with type 1 diabetes. Thirty adults with type 1 diabetes were given 16g of oral carbohydrates when their blood glucose reached a target …

This study looked at how often children with a rare adrenal gland problem (congenital adrenal insufficiency) experience dangerously low blood sugar. Even with standard treatment, these children may have low blood sugar without obvious symptoms. Researchers monitored 9 children ag…

This study looked at how often low blood sugar (hypoglycemia) occurs in elderly diabetic patients living in nursing homes. Researchers used a continuous glucose monitor worn on the skin for 14 days to track blood sugar levels. The goal was to better understand the frequency and c…

This study looks at whether using an automated insulin delivery system (a smart insulin pump and continuous glucose monitor) along with a low-carbohydrate diet can help restore the body's natural glucagon response to low blood sugar in people with type 1 diabetes. The glucagon re…

This study tested whether continuous glucose monitors (CGMs) can reliably track blood sugar levels in newborns at risk of low blood sugar (hypoglycemia) during their first 72 hours. Researchers enrolled 25 babies born large for gestational age or to mothers with diabetes. The goa…

This study followed 87 active adults with type 1 diabetes who use automated insulin pumps and exercise at least twice a week. Researchers tracked their blood sugar levels before, during, and after exercise to see how well the pumps handle physical activity. The goal was to learn …

This study looked at how different types of exercise—short bursts of intense cycling versus steady moderate cycling—affect blood sugar levels in adults with type 1 diabetes. It also compared exercising after a meal versus on an empty stomach. Twenty-one physically active adults c…

This completed study at Brigham and Women's Hospital looked at how a moderately low blood sugar stress affects the brain and nervous system in 74 healthy adults. Participants underwent a procedure to lower blood sugar while brain scans measured changes in key brain regions. The g…

This study looked at how low blood sugar (hypoglycemia) affects the body's automatic nervous system, which controls heart rate and blood pressure. Researchers tested whether the drug spironolactone could block these effects in 28 healthy adults. Participants underwent controlled …

This study looked at how low blood sugar (hypoglycemia) affects the body's ability to control heart rate in people with well-controlled type 2 diabetes. Fourteen adults underwent two sessions of low blood sugar while their heart rate regulation was measured. The goal was to under…

This study looked at 62 people with type 1 diabetes to see if a test that measures the hormone glucagon can predict the risk of dangerously low blood sugar (hypoglycemia). Participants drank a special liquid meal or received an arginine injection to stimulate glucagon release, an…

This study looked at whether chemicals in the breath (VOCs) match blood sugar levels in people with type 2 diabetes. Twenty adults with diabetes had their breath and blood sugar measured after drinking sugar water and receiving insulin. The goal was to see if a breath test could …

This study looked at how often people with reactive hypoglycemia (low blood sugar after eating) experience low blood sugar in their daily lives. 21 participants wore a continuous glucose monitor for 14 days to track their blood sugar levels. The goal was to understand how common …

This study looked at how often older adults with diabetes in long-term care facilities experience low blood sugar (hypoglycemia). Researchers used a continuous glucose monitor (CGM) worn for 10 days to track blood sugar levels in 86 participants. The goal was to better understand…

This study looked at whether continuous glucose monitors (CGMs) can help predict low blood sugar (hypoglycemia) in adults with type 2 diabetes. 41 participants wore either a regular CGM or a hidden one for a period of time. The goal was to compare how often low blood sugar occurr…

This study looked at 100 ICU patients to see if a continuous glucose monitor (CGM) works as well as standard fingerstick tests for tracking blood sugar. The goal was to find out if CGM is reliable enough to use in the ICU. Results will help doctors decide if this technology can i…

This completed study looked at 20 adults with bulimia or binge eating disorder to see if low blood sugar levels trigger eating binges. Participants wore a continuous glucose monitor and kept a food diary for 14 days. The goal was to understand whether blood sugar dips lead to cri…

This study placed a continuous glucose monitor (CGM) on 24 preterm infants born before 31 weeks to track their blood sugar levels for up to 10 days. The goal was to see how well the device detects high and low blood sugar, and to link those readings to the babies' growth and brai…