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Can a common drug shield the heart from low blood sugar?

NCT ID NCT03429946

Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how low blood sugar (hypoglycemia) affects the body's automatic nervous system, which controls heart rate and blood pressure. Researchers tested whether the drug spironolactone could block these effects in 28 healthy adults. Participants underwent controlled low blood sugar episodes with and without the drug to compare heart and nerve responses.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Spironolactone
What this could lead to
If successful, this could point toward a way to prevent heart-related complications from low blood sugar in people with diabetes.
What could go wrong
This is a small, early-stage study in healthy volunteers, not people with diabetes. Results may not apply to real-world patients, and spironolactone has side effects like high potassium levels.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

28 people

The number who actually took part.

Started

Jul 2013

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy volunteers * Males and females age 18 to 55 years Exclusion Criteria: * Pregnancy * Lactation * Clinically evident coronary artery, cerebrovascular, or peripheral vascular disease, or presence of systemic illness that might affect autonomic function. Such illnesses include diabetes mellitus, congestive heart failure, hypertension, renal, pulmonary, hepatic disease, anemia, malignancies, untreated thyroid disease, and alcoholism. * Current major depressive illness * In all subjects, any individuals on oral, injected, inhaled or topical corticosteroids within the last year or oral contraceptives within the past 3 months will be excluded. * Use of medications other than thyroxine * Known hypersensitivity to nitroglycerin, nitroprusside and/or phenylephrine. * Blood pressure \> 140/90 mmHg * Creatinine \> 1.5 mg/dL * Serum potassium \>5.2 mmol/L * Estimated GFR \< 50 mL/min * Use of Viagra, Cialis, and similar drugs within 72 hours of admission.

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Conditions

The condition(s) this trial relates to.

hypoglycemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy Hypoglycemia

Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02115, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

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