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Brain scans reveal how stress from low blood sugar rewires neural networks

NCT ID NCT03867344

Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study at Brigham and Women's Hospital looked at how a moderately low blood sugar stress affects the brain and nervous system in 74 healthy adults. Participants underwent a procedure to lower blood sugar while brain scans measured changes in key brain regions. The goal was to understand how non-psychological stress impacts brain networks that control automatic body functions like heart rate and breathing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

74 people

The number who actually took part.

Started

Oct 2019

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy volunteers * Males and Females age 18 to 45 years * BMI 18-35 kg/m2 Exclusion Criteria: * Pregnancy * Lactation * Menopause * Any medical condition * Current or prior alcohol or drug abuse * Active tobacco use * Abnormal ECG * In all subjects, any individuals on oral, injected, inhaled or topical corticosteroids within the last year or oral contraceptives within the past 3 months will be excluded. * Use of medications other than thyroid hormone or hormonal birth control * Serum potassium \>5.0 mmol/L * Estimated GFR \<60 mL/min/1.73 m2 * Hemoglobin A1c ≥6.5% * Patient Health Questionnaire (PHQ9) for depression score ≥15 * GAD-7 Questionnaire for anxiety score ≥10 * PTSD Checklist for DSM-5 (PCL-5) score ≥31 * Perceived Stress Scale (PSS-14) score \>28 * Blood pressure systolic ≥140 or \<100 mmHg; Blood pressure diastolic \>90 mmHg * Metal in the body including: cardiac pacemakers, stents, artificial heart valves, artificial limbs or hands, brain stimulator devices, implanted drug pumps, ear implants, eye implants or known metal fragments in eyes, exposure to shrapnel or metal filings (wounded in military combat, sheet metal workers, welders, and others), other metallic surgical hardware in vital areas, certain tattoos with metallic ink, certain transdermal medication patches, and metal-containing IUDs

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Conditions

The condition(s) this trial relates to.

hypoglycemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypoglycemia Physiological stress

Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02115, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

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