Hip fracture

This trial tests whether citicoline, a neuroprotective agent, can prevent or slow cognitive decline in older adults who develop delirium while hospitalized for a hip fracture. Delirium is a common complication that can lead to lasting memory and thinking problems. Participants wi…

This study compares two common surgeries for a certain type of hip fracture in adults aged 60 and older: hip replacement (arthroplasty) versus internal fixation (using screws or pins). The goal is to see which approach helps people survive, walk independently, and spend more time…

This trial tests whether adding bone cement to the standard metal nail used in hip fracture surgery helps the repair hold together better. People aged 75 and older with a certain type of hip fracture will be randomly assigned to receive either the standard surgery or the surgery …

This study is checking how well the Z1 Femoral Hip System works and how safe it is for people who need hip replacement surgery. About 150 adults with hip problems like arthritis or fractures will be followed for 2 years. The main goal is to see how many implants are still in plac…

This study looks at whether doing hip fracture surgery within 6 hours, instead of waiting longer, can reduce deaths in patients who also have a recent heart injury. About 1100 adults aged 45 and older with a hip fracture and elevated troponin (a sign of heart damage) will be rand…

This study will follow 120 adults aged 60 and older who have a pelvic fracture and are scheduled to receive the iFuse TORQ TNT implant, a screw-like device that stabilizes the pelvis. Researchers will check if the device stays in place, doesn't break, and doesn't require addition…

This trial tests whether a protein-rich diet combined with supervised resistance exercise can improve recovery in older adults who have had a hip fracture. Participants will follow this program for three months, and researchers will measure changes in physical function, muscle ma…

This trial tests whether a 14-week, individually tailored home-based rehabilitation program called 'Stronger at Home' can improve functional recovery in older adults who have had a hip fracture. Participants will receive visits from a physical therapist, a self-directed toolkit w…

This trial compares robot-assisted reduction with traditional manual methods for treating a common type of hip fracture in adults aged 18 to 80. The goal is to see if the robotic system can achieve more precise bone alignment, reduce radiation exposure, and improve long-term hip …

This study looks at how well a specific hip implant (CoCrMo LOCK bipolar femoral head) works for people who have had a hip fracture. Researchers will check how many patients need a second surgery or experience complications like dislocation within two years. The study includes 60…

This study tests whether giving blood transfusions quickly when hemoglobin drops can prevent delirium (sudden confusion) in patients 75 and older after hip fracture surgery. About 198 participants will be randomly assigned to either early transfusion or standard care. Researchers…

This study follows 120 people who need hip revision surgery (replacing a previous hip implant) to see how well the Prevision hip stem works. The stem comes in different versions, and surgeons choose the best one for each patient. The main goal is to measure how well patients can …

This study compares two surgeries for a common type of hip fracture in older adults: a metal nail inside the bone versus a full hip replacement. The goal is to see which approach leads to better mobility, fewer complications, and higher quality of life. About 170 people aged 65 a…

This study looks at whether a special vibrating device placed on the chest can improve breathing in older patients with a hip fracture who also have respiratory failure. 60 participants will receive the therapy for 5 days, and doctors will check their blood oxygen levels and lung…

This study follows 368 adults who need a partial hip replacement (hemiarthroplasty) due to fractures, arthritis, or bone death. Researchers will check how well Corin hip devices work and how safe they are over 10 years. The goal is to see if patients can move better and have fewe…

This study looks at whether giving two doses of tranexamic acid (a drug that helps blood clot) is better than one dose at reducing blood loss and the need for blood transfusions in older adults having hip fracture surgery. The trial includes 120 people aged 65 and older. Particip…

This study is testing a fracture liaison service (FLS) combined with medication management for people with osteoporosis in a rural area. The program provides education, monitoring, and follow-up to help patients take their medications as prescribed. Researchers will enroll 200 ad…

This study looks at whether older adults who break a hip from a simple fall might have an undiagnosed spinal cord condition called cervical myelopathy. Researchers will check 75 patients with a physical exam and, if needed, an MRI before they leave the hospital. The goal is to fi…

This study checks if a computer tool called BBCT-hip can accurately predict the risk of breaking the thigh bone (femur) when a person falls. Researchers will enroll 300 postmenopausal women with osteoporosis—150 who have already had a fracture and 150 who have not. All will get a…

This study tests a simple, family-led protocol called 'Delirium Zero' to prevent delirium (sudden confusion) in older adults after hip fracture surgery. About 140 patients over 65 will be randomly assigned to either standard care or the Delirium Zero protocol, which includes an o…

This study tests a procedure called LOEP that strengthens the hip bone to prevent a second fracture in women over 65 with osteoporosis who have already broken one hip. About 2400 women will either receive the procedure or standard care and be followed for at least 5 years. The go…

This study tests whether using a positive expiratory pressure (PEP) device before and after hip fracture surgery can prevent hospital-acquired pneumonia. About 566 patients will either receive the PEP therapy plus standard care or standard care alone. The goal is to see if this s…

This trial tests whether a structured educational program, including an illustrated booklet, can improve recovery after hip fracture surgery. Participants are randomly assigned to receive the program plus routine care or routine care alone. The study measures functional independe…

This trial tests whether a computer navigation system called ADAPT helps surgeons place screws more accurately during hip fracture repair. About 96 adults aged 50-85 with certain hip fractures will be randomly assigned to receive surgery with or without the navigation system. The…

This study tests two types of nerve blocks—anterior iliopsoas space block and PENG block—to see which helps patients with hip fractures get into position for spinal anesthesia more easily and with less pain. About 90 adults undergoing hip surgery will receive one of the blocks be…

This study looks at whether a new type of nerve block, called the Quadro-Iliac Plane (QIP) block, helps people recover better after hip replacement surgery. Researchers will compare it to other standard blocks by measuring pain, how quickly people get up and move, and overall rec…

This study tests whether adding regional anesthesia, such as nerve blocks, to standard pain treatment can reduce opioid use and pain after pelvic or acetabular fracture surgery. Adults undergoing surgery for these fractures may receive ultrasound-guided nerve blocks with a long-a…

This trial asks whether adding morphine to spinal anesthesia or using an ultrasound-guided nerve block provides better pain control after hip surgery. Sixty-four adults having hip replacement or hip fracture surgery will be randomly assigned to one of the two methods. Researchers…

This study tests whether a mobile app can help patients do simple in-bed exercises after orthopedic surgery for spine, hip, or knee problems. About 100 participants will use the app or receive usual care. Researchers will measure how well patients recover their ability to move an…

This trial compares two types of nerve blocks—the newer PENG block and the traditional femoral nerve block—given before spinal anesthesia for hip fracture surgery. The goal is to see which one better reduces pain and helps patients sit comfortably for the spinal injection. Adults…

This study tests whether a specific nerve block, called the deep iliacus plane block, can reduce the amount of opioid pain medication needed after hip fracture surgery. Half of the participants receive the real block with bupivacaine, while the other half receive a sham (fake) bl…

This trial compares intravenous (IV) acetaminophen to oral acetaminophen for managing pain and preventing delirium in adults aged 60 and older after hip fracture surgery. Participants receive either IV acetaminophen plus a placebo pill, or IV placebo plus oral acetaminophen, ever…

This trial tests whether adding a second nerve block to the standard one helps people with hip fractures feel less pain while being positioned for spinal anesthesia before surgery. The study compares the usual pericapsular nerve group (PENG) block alone versus the PENG block comb…

This study will compare three pain management methods after hip surgery in 108 adults aged 65 and older. The methods are a nerve block (PENG block), a local anesthetic injection around the joint (periarticular injection), or both combined. The goal is to see which approach reduce…

This study compares a new local anesthesia technique called PENG 360° to standard spinal anesthesia for people having hip replacement surgery after a fracture. The goal is to see if the new method controls pain just as well while allowing patients to move their leg sooner. One hu…

This study tests whether a single intravenous dose of iron (ferric derisomaltose) can improve mobility recovery in elderly patients after hip fracture surgery. Researchers will compare the iron group to a placebo group in 210 participants across three Danish hospitals. The main g…

This study compares two types of nerve blocks (meta-PENG and fascia iliaca) to see which one better reduces pain during hip fracture surgery. About 80 adults having hip fracture surgery will receive one of the blocks as part of their routine care. The goal is to find which block …

This study tests whether using blood flow restriction cuffs during low-intensity stationary cycling can safely improve muscle strength and mobility in older adults recovering from a hip fracture. Sixty hospitalized patients over age 65 will be randomly assigned to either real or …

This study compares two types of nerve blocks (PENG vs femoral) to see which provides better pain relief for people with hip fractures. About 352 adults with a hip fracture will receive one of the two blocks, depending on the month they come to the hospital. Researchers will meas…

This study compares two types of nerve blocks—suprainguinal fascia iliaca block (SIFI) and quadro-iliac plane block (QIPB)—for pain relief after hip fracture surgery. Researchers will enroll 70 adults undergoing hip fracture repair and measure pain scores and opioid use. The goal…

This study compares two types of nerve blocks—the PENG block and the Deep Iliacus Plane Block—for pain relief during spinal anesthesia positioning and after hip fracture surgery. 75 adults aged 30-85 will receive one of the blocks plus standard pain medication. The goal is to see…

This pilot study is testing whether a dual-screw nail (InterTAN) helps people recover better after a broken hip than a standard single-screw nail (TFNA). Thirty adults with unstable hip fractures will be randomly assigned to receive one of the two devices during surgery. The rese…

This study tests whether remimazolam, a newer anesthesia drug, causes less confusion (delirium) after surgery than the standard drug propofol in elderly patients having hip or knee replacement. Researchers will monitor 82 participants for three days after surgery to check for del…

This study is testing whether adding a sensor-based device to standard physical therapy can improve both thinking and movement in frail older adults recovering from hip fracture surgery. Thirty participants aged 65-89 will use the device for part of their rehab. The goal is to se…

This study tests whether a long-acting form of the anesthetic bupivacaine, combined with regular bupivacaine, can control pain better than the standard drug ropivacaine after hip replacement. Sixty adults with hip fractures or necrosis will receive one of the two treatments via a…

This study tests whether a nutritional supplement (complex carbohydrates and essential amino acids) taken for three weeks after hip fracture surgery can reduce muscle loss in adults aged 65 and older. Participants are randomly assigned to receive either the supplement or standard…

This study compares two types of nerve blocks—sacral erector spinae plane block and pericapsular nerve group block—for pain relief after hip hemiarthroplasty. Eighty adults aged 50-90 with a hip fracture will receive one of the blocks before surgery. Researchers will measure pain…

This pilot study tests whether personalized audio-recorded messages, played three times daily for the first three days after hip fracture surgery, can help prevent delirium in patients aged 60 and older. The study will enroll 30 participants and focus on whether the intervention …

This study looks at whether adding local muscle vibration to standard rehabilitation can help elderly patients (75+) recover strength and mobility after a hip fracture. The vibration is applied to the leg muscles for 30 minutes, five times a week, for four weeks. The main goal is…

This study tests whether giving elderly patients a combination of esketamine and dexmedetomidine after hip fracture surgery can improve their sleep quality. 96 patients aged 65 and older will be randomly assigned to receive either the drug combo or a placebo (saline) for 48 hours…

This study tests if freezing a specific nerve group (cryoablation of the PENG) provides better pain control 30 days after hip fracture surgery compared to the usual method (a fascia iliaca catheter). About 150 adults aged 18-85 having hip fracture repair will be enrolled. The mai…

This study compares standard pain management to a special nerve block called PENG in 70 adults having hip fracture surgery. The goal is to see if the block reduces pain, the need for extra painkillers, and helps patients get moving faster. Researchers will also check for side eff…

This study tests two sedative drugs, remimazolam and midazolam, in adults aged 65 and older having orthopedic surgery with regional anesthesia. The goal is to see which drug provides better sedation during surgery and causes fewer problems with thinking and memory shortly after. …

This study tests a treatment called Remote Ischaemic Conditioning (RIC) for people recovering from hip fracture surgery. RIC involves inflating a blood pressure cuff on the arm or leg for short periods to trigger the body's own protective responses. The trial will include 12 adul…

This study at Montpellier University Hospital will look at whether low muscle mass and strength before hip replacement surgery affects how well people aged 75 and older regain their independence. About 20 volunteers will have blood tests, scans, and a tiny muscle sample taken dur…

This study checks if a French version of the New Mobility Score (NMS) works well for older adults hospitalized after a hip fracture. The NMS is a simple test that measures how well a person can move indoors, outdoors, and while shopping. Researchers will test it with 100 patients…

This study looks at why some older adults with serious conditions like cancer or fractures become vulnerable or frail. Researchers will follow about 1500 patients to find out how common different causes of vulnerability are and how they affect outcomes like survival and quality o…

This study is testing whether giving elderly patients with a broken hip and high frailty a special nutritional drink before surgery can help them stay more stable during the operation and recover better. Researchers will compare patients who get the drink with those who follow st…

This study looks at two ways to treat pelvic fractures in people aged 60 and older: surgery or non-surgical care. Researchers will follow 120 patients to see if a larger trial comparing these treatments is possible. The goal is to understand patient and surgeon preferences and wh…

This study will use data from 1,200 hip fracture patients to build a machine learning model that predicts mobility and daily living independence three months after injury. The goal is to help patients and doctors set realistic expectations for recovery. No new treatments are bein…

This study looks at whether surgery improves walking in older adults with pelvic ring fractures. Researchers will compare walking patterns and hospital outcomes between those who get surgery and those who don't. The goal is to see if surgery leads to better recovery and quality o…

This study is recruiting 100 people who need hip replacement surgery after a fragility fracture (a break from a minor fall) and comparing them to patients having hip replacement for arthritis. Researchers will use a simple questionnaire (SARC-F) and analyze bone and muscle tissue…

This study aims to translate and culturally adapt the Groningen Frailty Indicator (GFI) questionnaire for Greek patients with hip fractures. Researchers will enroll 89 adults over 65 who are undergoing hip fracture surgery. The goal is to create a reliable Greek version of the GF…

This study looks at whether older adults who are frail before hip fracture surgery have higher levels of inflammation, measured by simple blood tests. Researchers will enroll 200 patients aged 65 and older and check their frailty using a standard questionnaire. The goal is to bet…

This study compares two recovery approaches after surgery for pelvic fractures: starting to put weight on the leg immediately versus waiting a while. Researchers will track 50 adults aged 18 to 55 to see which group has better function, less pain, and stronger muscles. The goal i…

This study looks at whether measuring frailty—a person's overall physical weakness—can improve predictions of death within 90 days after hip fracture surgery. Researchers will follow about 200 older adults who have surgery for a broken hip. They will compare the standard risk sco…

This study collects bone marrow from 24 adults aged 65+ having hip surgery to understand how common aging-related blood cell mutations (called CHIP) change cell metabolism. Researchers will compare gene activity in mutated versus normal stem cells. The goal is to learn more about…

This study tests a simple conversation aid and brief training for doctors to improve discussions about anesthesia options with patients who need hip fracture surgery. About 1,881 adults aged 50 and older at six U.S. hospitals will take part. The goal is to see if this approach in…

This study looks at different ways to surgically fix a broken hip in adults under 65. The main goal is to see if a new implant keeps the bone more stable during healing compared to standard screws. Researchers will use a special X-ray method to measure any movement in the fractur…

This study looks at whether a blood test marker called Monocyte Distribution Width (MDW) can help predict complications and survival in elderly patients with hip fracture. Researchers will follow 100 patients aged 65 and older, measuring MDW and other inflammatory markers at admi…

This study is developing a decision tool to help doctors identify blunt trauma patients who can safely skip abdominal-pelvic CT scans, avoiding unnecessary radiation and expense. Researchers will collect data from 12,000 patients in the emergency department to find a set of clini…

This study looks at oxygen levels in adults over 65 after hip fracture surgery, comparing regional (spinal) anesthesia to general anesthesia. Researchers will measure oxygen saturation and track complications like sleep apnea, delirium, and hospital stay length. The study is obse…

This study looks at 374 hip fracture patients who take blood thinners (DOACs). Doctors often delay surgery due to bleeding concerns, but waiting may cause other problems. The study compares early surgery (within 24 hours) to delayed surgery to see if early surgery increases the n…

This observational study at Shanghai Geriatric Medical Center looks at how the anesthetic drug ciprofol behaves in 50 older adults (65+) undergoing limb surgery. Researchers will collect blood samples and monitor vital signs to build a model that could help doctors adjust doses m…

This study follows 200 people who have broken their pelvis or hip socket to see how they recover over time. Researchers will track when patients return to work and daily activities, and measure changes in physical function, mood, and pain. The goal is to better understand the rec…

This study looks at whether spinal anesthesia or general anesthesia leads to fewer lung complications after delayed hip fracture surgery in people aged 65 and older. Forty participants will be assigned to one of the two anesthesia types, and their lung function will be measured a…