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Race against time: can speedy hip surgery save more lives?

NCT ID NCT04743765

Disease control Sponsor: Population Health Research Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 27, 2026 · Updated 3 times

Summary

This study looks at whether doing hip fracture surgery within 6 hours, instead of waiting longer, can reduce deaths in patients who also have a recent heart injury. About 1100 adults aged 45 and older with a hip fracture and elevated troponin (a sign of heart damage) will be randomly assigned to either accelerated surgery or standard care. The main goal is to see if faster treatment lowers the chance of dying within 90 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
accelerated medical clearance and surgery
What this could lead to
If it works, this could show that faster surgery after a hip fracture lowers the risk of death for patients who also have a heart injury.
What could go wrong
This is a mid-stage trial, so results are not yet proven. The benefit may be small or not apply to all patients, and rushing surgery could increase risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2021

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. age ≥45 years; 2. diagnosis of hip fracture during working hours with a low-energy mechanism requiring surgery; 3. troponin elevation ( at least one troponin measurement above the upper limit of normal occurring from the time of hip fracture to the time of randomization); and 4. informed consent. Exclusion Criteria: 1. taking a therapeutic dose of an anticoagulant for which no reversing agent is available and the anesthesiologist or surgeon believe surgery within 6 hours of eligibility criteria met would not be safe; 2. patients on a therapeutic vitamin K antagonist with a history of heparin induced thrombocytopenia (HIT); 3. patients with peri-prosthetic fracture, open fracture or bilateral fractures; 4. patients requiring an emergency surgery for another reason (e.g., subdural hematoma); 5. patients with acute myocardial infarction deemed to be clinically unstable, with a mechanical complication (i.e., acute papillary muscle rupture, ventricular septal defect), ST elevation myocardial infarction, or cardiogenic shock; 6. patients refusing consent; or 7. patients previously enrolled in HIP ATTACK-2.

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Conditions

The condition(s) this trial relates to.

hip fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hip fractures Myocardial injury

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    43 sites in 17 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aga Khan University

    RECRUITING

    Karachi, Sindh, 74800, Pakistan

  • All India Institute of Medical Sciences (AIIMS)

    RECRUITING

    New Delhi, National Capital Territory of Delhi, 110029, India

  • B and B Hospital

    RECRUITING

    Lalitpur, Bagmati, 44700, Nepal

  • Bangalore Baptist Hospital

    RECRUITING

    Bangalore, Karnataka, 560024, India

  • Bryan Medical Center

    ACTIVE_NOT_RECRUITING

    Lincoln, Nebraska, 68506, United States

  • CISSS de Laval

    RECRUITING

    Laval, Quebec, H7M 3L9, Canada

  • Chandler Regional Medical Center

    ACTIVE_NOT_RECRUITING

    Chandler, Arizona, 85224, United States

  • Chelsea and Westminster Hospital

    RECRUITING

    London, SW10 9NH, United Kingdom

  • Christus Muguerza del Parque

    ACTIVE_NOT_RECRUITING

    Chihuahua City, Chihuahua, 31000, Mexico

  • Cleveland Clinic

    ACTIVE_NOT_RECRUITING

    Cleveland, Ohio, 44195, United States

  • Clinica Santa Maria

    RECRUITING

    Santiago, 7520378, Chile

  • Cliniques Universitaires Saint Luc - University Catholic of Louvain

    ACTIVE_NOT_RECRUITING

    Woluwe-Saint-Lambert, Brussels Capital, 1200, Belgium

  • Combined Military Hospital

    RECRUITING

    Rawalpindi, Punjab Province, 46000, Pakistan

  • Cruz Verde Guadalajara

    ACTIVE_NOT_RECRUITING

    Guadalajara, Jalisco, 44410, Mexico

  • Dartmouth-Hitchcock Medical Center

    ACTIVE_NOT_RECRUITING

    Lebanon, New Hampshire, 03756, United States

  • Deventer Hospital

    RECRUITING

    Deventer, Overijssel, 7416 SE, Netherlands

  • Emory University at Grady Memorial Hospital

    ACTIVE_NOT_RECRUITING

    Atlanta, Georgia, 30322, United States

  • Froedtert Hospital

    ACTIVE_NOT_RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Galliera Hospital

    RECRUITING

    Genova, 16128, Italy

  • Ghurki Trust Teaching Hospital

    ACTIVE_NOT_RECRUITING

    Lahore, Punjab Province, 54000, Pakistan

  • Government Medical College

    ACTIVE_NOT_RECRUITING

    Trivandrum, Kerala, 695011, India

  • Government TD Medical College

    ACTIVE_NOT_RECRUITING

    Alappuzha, Kerala, 688005, India

  • Groote Schuur Hospital

    RECRUITING

    Cape Town, Western Cape, 7925, South Africa

  • Hayat Abad Medical Complex

    RECRUITING

    Peshawar, KPK, 25000, Pakistan

  • Hospital Clinic of Barcelona

    RECRUITING

    Barcelona, Barcelona, 08036, Spain

  • Hospital Clinico Universitario de Vallad

    RECRUITING

    Valladolid, Valladolid, 47007, Spain

  • Hospital Costa del Sol

    RECRUITING

    Marbella, Malaga, 29603, Spain

  • Hospital Sant Camil

    RECRUITING

    Sant Pere de Ribes, Barcelona, 08810, Spain

  • Hospital Universitari Parc Tauli

    ACTIVE_NOT_RECRUITING

    Sabadell, Barcelona, 08208, Spain

  • Hospital Universitari Sagrat Cor

    RECRUITING

    Barcelona, Barcelona, 08029, Spain

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, Barcelona, 08035, Spain

  • Hospital Universitario Mutua de Terrassa

    RECRUITING

    Terrassa, Barcelona, 08221, Spain

  • Hospital Universitario Ramón y Cajal

    RECRUITING

    Madrid, 28034, Spain

  • Hospital de la Santa Creu I Sant Pau

    ACTIVE_NOT_RECRUITING

    Barcelona, Barcelona, 08041, Spain

  • Hospital of Perugia

    RECRUITING

    Perugia, Umbria, 06129, Italy

  • Indus Hospital & Health Network

    RECRUITING

    Karachi, Sindh, Pakistan

  • JIPMER

    RECRUITING

    Puducherry, Puducherry, 605006, India

  • Juravinski Hospital

    RECRUITING

    Hamilton, Ontario, L8V 1C3, Canada

  • King Faisal Specialist Hospital

    RECRUITING

    Riyadh, Riyadh Region, 11211, Saudi Arabia

  • Lahey Hospital and Medical Center

    ACTIVE_NOT_RECRUITING

    Burlington, Massachusetts, 01805, United States

  • Markham Stouffville Hospital

    RECRUITING

    Markham, Ontario, L3P 7P3, Canada

  • Maroof International Hospital

    RECRUITING

    Islamabad, ICT, 44000, Pakistan

  • Mayo Clinic

    ACTIVE_NOT_RECRUITING

    Rochester, Minnesota, 55905, United States

  • Montefiore Medical Center

    ACTIVE_NOT_RECRUITING

    The Bronx, New York, 10467, United States

  • Oregon Health and Science University

    ACTIVE_NOT_RECRUITING

    Portland, Oregon, 97239, United States

  • Ospedale Galeazzi SpA

    RECRUITING

    Milan, 20157, Italy

  • Ospedale San Raffaele S.r.l.

    RECRUITING

    Milan, 20132, Italy

  • Ottawa General Hospital

    RECRUITING

    Ottawa, Ontario, K1H 8L6, Canada

  • Parc Sanitari Sant Joan de Déu

    RECRUITING

    Barcelona, 08830, Spain

  • Pontifica Universidad Catolica de Chile

    RECRUITING

    Santiago, RM, 83300024, Chile

  • Queen Mary Hospital

    RECRUITING

    Hong Kong, Hong Kong

  • SPZOZ Myslenice

    RECRUITING

    Myślenice, Malopolska, 32-400, Poland

  • Shifa International Hospitals Ltd.

    RECRUITING

    Islamabad, ICT, 44000, Pakistan

  • Sinai Hospital of Baltimore

    ACTIVE_NOT_RECRUITING

    Baltimore, Maryland, 21215, United States

  • South Karelia Central Hospital

    ACTIVE_NOT_RECRUITING

    Lappeenranta, 53130, Finland

  • St. Joseph's Healthcare Hamilton

    RECRUITING

    Hamilton, Ontario, L8N 4A6, Canada

  • St. Luke's University Health Network

    ACTIVE_NOT_RECRUITING

    Bethlehem, Pennsylvania, 18015, United States

  • Stellenbosch University - Tygerberg Hospital

    ACTIVE_NOT_RECRUITING

    Cape Town, Western Cape, 7505, South Africa

  • Stichting OLVG

    RECRUITING

    Amsterdam, 1091, Netherlands

  • Tampere University Hospital

    RECRUITING

    Tampere, 33521, Finland

  • The John Hunter Hospital

    RECRUITING

    New Lambton Heights, New South Wales, 2305, Australia

  • The Regents of the University of California

    ACTIVE_NOT_RECRUITING

    Davis, California, 95618, United States

  • The University of Texas Health Science Center at Houston

    ACTIVE_NOT_RECRUITING

    Houston, Texas, 77030, United States

  • The University of Texas Southwestern Medical Center (UTSW)

    ACTIVE_NOT_RECRUITING

    Dallas, Texas, 75390, United States

  • Tufts Medical Center

    ACTIVE_NOT_RECRUITING

    Boston, Massachusetts, 02111, United States

  • University Medical Center of Southern Nevada

    ACTIVE_NOT_RECRUITING

    Las Vegas, Nevada, 89102, United States

  • University of Alberta Hospital

    ACTIVE_NOT_RECRUITING

    Edmonton, Alberta, T6G 2B7, Canada

  • University of California, Irvine

    ACTIVE_NOT_RECRUITING

    Irvine, California, 92697, United States

  • University of Malaya Medical Centre

    RECRUITING

    Kuala Lumpur, 59100, Malaysia

  • University of Maryland

    ACTIVE_NOT_RECRUITING

    Baltimore, Maryland, 20742, United States

  • University of Michigan

    ACTIVE_NOT_RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of São Paulo

    RECRUITING

    São Paulo, São Paulo, 05403010, Brazil

  • University of Utah

    ACTIVE_NOT_RECRUITING

    Salt Lake City, Utah, 84112, United States

  • University of Wisconsin

    ACTIVE_NOT_RECRUITING

    Madison, Wisconsin, 53715, United States

  • Victoria Hospital

    RECRUITING

    London, Ontario, N6A 5W9, Canada

  • West Middlesex University Hospital

    RECRUITING

    Middlesex, TW7 6AF, United Kingdom

  • Yale New Haven Hospital

    ACTIVE_NOT_RECRUITING

    New Haven, Connecticut, 06520, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.