Population Health Research Institute

This study looks at whether blood thinners can prevent strokes in people who had a short episode of atrial fibrillation (irregular heartbeat) triggered by stress, such as after surgery or a serious illness. About 2,270 adults with additional stroke risk factors will either take a…

This study looks at whether using a lower INR target (1.5 to 2.5) can reduce bleeding in people with a mechanical heart valve in the aortic position. About 2,625 adults who had valve surgery at least 3 months ago will take part. The goal is to see if this approach lowers bleeding…

This study compares bariatric (weight-loss) surgery to standard medical weight management in 200 adults with severe obesity (BMI 30 or higher) and high-risk cardiovascular disease. The goal is to see if surgery reduces major heart problems like heart attacks, strokes, and heart f…

This study tests whether colchicine, an anti-inflammatory drug used for gout, can reduce the risk of major heart problems and limb complications in people with peripheral artery disease (PAD). About 6,150 adults with symptomatic PAD will take either low-dose colchicine or a place…

This study looks at whether having hip fracture surgery sooner (within hours) can lower the chance of death within 90 days for patients who also have a recent heart injury. About 1,100 adults aged 45 and older with a hip fracture and elevated troponin (a sign of heart damage) wil…

This study tests whether a widely used antibiotic (azithromycin) can reduce deaths in adults with advanced HIV. About 8,000 participants will receive either the antibiotic or a placebo. The goal is to see if this simple, low-cost approach can save lives in the first 24 weeks of t…

This study compares two types of blood thinners (DOACs and vitamin K antagonists) in 3,500 adults who had open-heart surgery and have atrial fibrillation. The goal is to see which drug causes fewer major bleeding events in the first 30 days after surgery. Participants are randoml…

This study aims to see if a simple heart pacing test can diagnose Calcium Release Deficiency Syndrome (CRDS), a rare genetic heart condition that raises the risk of sudden cardiac death. Researchers will compare results from people with CRDS, those with a similar condition (CPVT)…

This study is creating a global registry for people with Calcium Release Deficiency Syndrome (CRDS), a rare genetic heart condition that can cause dangerous heart rhythms. Researchers will collect health information from 500 participants to better understand the disease, identify…