Population Health Research Institute

This study is testing whether weight loss surgery can reduce heart attacks, strokes, and heart failure in people with severe obesity and existing heart disease. Researchers will compare surgery against medication-based weight management in 200 participants. The trial will also ex…

This international study is testing whether performing hip fracture surgery faster than usual improves survival for patients who also show signs of recent heart injury. The trial will compare accelerated surgery to standard care in 1100 adults aged 45+ with hip fractures and elev…

This study aims to find out which type of blood thinner is safer for patients in the first month after heart surgery when they need protection from strokes due to atrial fibrillation. It will compare newer direct oral anticoagulants (DOACs) with the older standard, vitamin K anta…

This large international trial is testing whether a 28-day course of the antibiotic azithromycin can reduce deaths in adults with very advanced HIV. It will enroll 8,000 participants with severely weakened immune systems and follow them for nearly a year. The goal is to see if th…

This large, late-stage trial is testing whether a low daily dose of an existing anti-inflammatory drug (colchicine) can prevent serious complications in people with symptomatic peripheral artery disease (PAD). It aims to see if the drug reduces the combined risk of heart attacks,…

This study aims to find the safest dose of the blood thinner warfarin for people with mechanical heart valves. It will test if aiming for a lower blood-thinning level reduces serious bleeding while still preventing dangerous blood clots and strokes. The trial involves over 2,600 …

This study aims to develop a new clinical test to diagnose Calcium Release Deficiency Syndrome (CRDS), a rare genetic condition that can cause sudden cardiac death. Researchers will test a procedure where they briefly speed up and then pause the heart using a pacemaker to look fo…

This study aims to find out if taking blood-thinning pills can prevent strokes and other serious heart problems in people who recently had temporary atrial fibrillation (an irregular heartbeat) triggered by stress, surgery, or illness. Researchers will compare outcomes between pe…

This study is creating a global registry to learn about a rare, newly discovered genetic heart condition called Calcium Release Deficiency Syndrome (CRDS). It aims to enroll 500 people who carry specific genetic changes to better understand the range of symptoms, identify risks, …