Can a drug cocktail help seniors sleep after hip surgery?
NCT ID NCT07002723
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving elderly patients a combination of esketamine and dexmedetomidine after hip fracture surgery can improve their sleep quality. 96 patients aged 65 and older will be randomly assigned to receive either the drug combo or a placebo (saline) for 48 hours. Researchers will track sleep, pain, and confusion levels after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- esketamine combined with dexmedetomidine
- What this could lead to
- If it works, this could offer a way to help elderly patients sleep better after hip surgery, potentially reducing confusion and speeding recovery.
- What could go wrong
- This is a small, early-stage trial (96 people) testing a drug combination for a short-term effect. It may not show a meaningful benefit, and the drugs can cause side effects like drowsiness or nausea.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 96 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2025
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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65 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age≥ 65 years old; * Hip fracture surgery under neuraxial anesthesia; * Signed informed consent. Exclusion Criteria: * ASA classification≥ Class V; * Presence of neuraxial anesthesia contraindications: coagulation dysfunction, thrombocytopenia, neuraxial mass, puncture site infection, etc.; * Patients with contraindications to esketamine (such as allergies, intracranial aneurysms, hyperthyroidism and glaucoma); * Patients with contraindications to dexmedetomidine (allergies); * Patients with severe cardiovascular diseases such as sick sinus syndrome, severe sinus bradycardia (heart rate \< 50 beats/min), atrioventricular block grade II or above without pacemaker, unstable angina, severe valvular heart disease, severe arrhythmia, severe macrovascular disease with New York Heart Association class III patients, etc.; * Obstructive sleep apnea syndrome (STOP-BANG score \> 3 points); * Patients with severe hepatic and renal insufficiency (such as Child-Pugh score III, creatinine clearance \< 35 mL/min, preoperative dialysis); * Those who have delirium, dementia, moderate to severe cognitive dysfunction and psychiatric disorders before the start of the trial and are unable to communicate and cooperate with the investigator.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Peking University Shenzhen Hospital
RECRUITINGShenzhen, Guangdong, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a small electrical device cut painkiller use after hip surgery?
- Can a common sedative added to spinal anesthesia keep older minds clear after hip surgery?
- Can a new hip buffer restore mobility after fractures?
- Can a gentler spinal anesthesia keep frail patients' blood pressure steadier during hip surgery?
- Can diet and exercise rebuild strength after a hip fracture?
- Can a Bone-Strengthening infusion given right after hip surgery prevent a second break?