Fatty liver disease

Researchers are testing whether a low-frequency high-intensity interval training (HIIT) program can reduce body fat and liver fat in adults with central obesity and non-alcoholic fatty liver disease. The trial enrolls 160 adults aged 18 to 60 who have a BMI of at least 25 and a l…

This trial tests whether an essential amino acid supplement can lower fat stored in the liver of teenagers with non-alcoholic fatty liver disease (NAFLD). Participants aged 13 to 18 will take the supplement or a placebo for two months, and researchers will measure liver fat with …

This study tests whether a supplement made from brown algae and chromium picolinate, when added to a calorie-controlled Mediterranean diet, can reduce fat buildup in the liver. Adults with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic syndrome wil…

This trial investigates whether two common osteoporosis medications, denosumab and alendronate, can reduce liver fat and scarring in postmenopausal women who also have nonalcoholic fatty liver disease (NAFLD). The study will compare changes in liver fat and stiffness over 12 mont…

This trial is testing whether a special supplement containing silibin, glutathione, and vitamin E can reduce fat buildup in the liver and improve liver function in people with MASLD (a common fatty liver disease linked to metabolism). Over 42 adults, each person will take the sup…

This study tests whether combining two diabetes drugs—semaglutide and empagliflozin—can reverse liver damage from NASH (a severe form of fatty liver disease) in people with type 2 diabetes. Participants will receive either the combo, empagliflozin alone, or a placebo for 48 weeks…

This study tests whether a daily probiotic lysate supplement can reduce fat and stiffness in the liver of adults with non-alcoholic fatty liver disease (NAFLD). Participants take either the supplement or a placebo for three months, and doctors measure changes using MRI and ultras…

This study tests whether a daily capsule containing fragments of a probiotic bacterium (L. rhamnosus) can reduce liver fat and improve blood markers in adults with metabolic dysfunction-associated steatotic liver disease (MASLD). Participants take either the supplement or a place…

This early-stage trial tested a new drug, LY3849891, in 115 people with fatty liver disease who carry a specific gene variant (PNPLA3 I148M). The main goal was to check safety and how the body processes the drug. Researchers also looked at changes in liver fat and inflammation us…

This study tested whether regularly removing blood (like donating blood) can lower iron levels and improve diabetes control and fatty liver disease. 132 adults aged 40-75 with prediabetes or diabetes took part. The treatment group gave blood several times, while the control group…

This Phase 2 trial tested a drug called DD01 in 67 overweight or obese adults with a type of fatty liver disease (MASLD/MASH). The goal was to see if DD01 could safely reduce liver fat by at least 30% over 48 weeks compared to a placebo. The study is completed, and results will s…

This study looked at whether adding rice bran to nutrition education helps people with fatty liver disease. 58 overweight or obese adults with moderate fatty liver were split into two groups: one got nutrition education alone, the other got nutrition education plus rice bran. Res…

This study looked at whether a Mediterranean diet, with or without added exercise, could help people with a type of fatty liver disease called MASLD. The goal was to see if the diet could reduce fat and scarring in the liver. 96 adults took part, and researchers used special MRI …

This study tested a new drug called BIO89-100 (Pegozafermin) in 222 adults with NASH, a serious fatty liver disease with liver scarring. Participants received weekly injections of the drug or a placebo for about 6 months. The goal was to see if the drug could reduce liver inflamm…

This early-stage trial tested an experimental drug called BI 3006337 in 64 adults who are overweight or obese and have fatty liver disease. Participants received weekly injections of either the drug or a placebo for about 4 months. The main goal was to check safety and tolerabili…

This study tested a drug called tesamorelin in 51 obese adults with nonalcoholic fatty liver disease (NAFLD). The drug is designed to increase growth hormone levels, which may help reduce liver fat and inflammation. Researchers measured changes in liver fat using special scans an…

This study looked at whether eating only during a set window each day (time-restricted eating) combined with supervised exercise can reduce fat in the liver and improve heart health in adults with obesity. 187 people took part. The goal was to see if the combination works better …

This study tested whether a 4-week program of inspiratory muscle training (using a POWERbreathe® device) could improve diaphragm thickness, reduce fatty liver, and increase aerobic capacity in 30 healthy men aged 60-80. Participants were split into a training group and a control …

This study looked at whether an 8-week 5:2 intermittent fasting diet could help people with fatty liver disease. Eighty adults with excess liver fat followed the diet, eating normally for 5 days and restricting calories to 500 kcal on 2 non-consecutive days each week. Researchers…

Researchers are testing the Liver Incyte system, an ultrasound device that measures how stiff the liver is, to see if it can tell healthy people apart from those with liver fibrosis or steatosis. The trial includes 140 adults, some healthy and some with a history of hepatitis C o…

This study tests a new ultrasound-based device called the Liver Incytes System to see if it can measure liver stiffness and fat as accurately as MRI and FibroScan. The device uses sound waves to create images of the liver, similar to a traditional ultrasound. Researchers are enro…

This study tests whether a device called Fibroscan can diagnose fatty liver disease (steatosis) without needing a biopsy. Researchers will measure liver stiffness and viscosity in 72 people, including healthy volunteers and patients with confirmed fatty liver. Results will be com…

This study looked at whether giving doctors the results of a blood test called ELF helps them better diagnose advanced liver scarring (fibrosis) in people with fatty liver disease. About 450 patients were randomly assigned to have the ELF test or not during their liver clinic vis…

This study tested whether an artificial intelligence (AI) program can accurately measure liver fat using regular ultrasound images in children aged 8 to 18 with fatty liver disease. The AI's results were compared to MRI scans, which are the current gold standard. The goal is to p…

This study looked at whether a 4-week moderate resistance training program could improve diaphragm thickness, liver fat, and quality of life in healthy men aged 60-75. Thirty participants were split into an exercise group or a control group that kept their normal routine. Researc…

This study looked at how people with and without non-alcoholic fatty liver disease (NAFLD) process food. Researchers monitored 53 adults over two days, measuring metabolism, blood, and urine after meals. The goal was to find differences that might explain why fat builds up in the…

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This study looked at liver fibrosis (scarring) in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Participants underwent tests like liver biopsy, ultrasound, and CT scans to measure liver damage. The goal was to understand how common and severe liver …

This study looks at whether two popular weight-loss medications, semaglutide and tirzepatide, can improve early signs of liver damage in people with overweight or obesity. Researchers measured changes in liver health markers after at least 12 weeks of treatment in 154 adults. The…

This study investigates how the liver processes nutrients after a meal in healthy individuals and in patients with fatty liver disease or cirrhosis. Researchers will take blood samples and liver biopsies after fasting or eating a standardized meal, and after a glucagon injection.…

This study looked at 315 HIV-positive adults to build models that predict fatty liver disease and liver scarring. Researchers used ultrasound and FibroScan tests to track liver changes over time. The goal was to better understand and identify liver problems early in people living…

This completed study tested different ways to use an ultrasound machine to measure liver fat in 35 healthy adults. The goal was to find the most reliable technique for non-invasively diagnosing fatty liver disease, a common condition linked to obesity and diabetes. By standardizi…

This completed study followed 1,681 people with steatotic liver disease (fatty liver) in Germany to observe how the condition progresses over time. Researchers measured liver stiffness, inflammation, and tracked whether participants developed heart problems or tumors. The goal wa…

This study tested whether a pop-up alert in the electronic medical record could help doctors remember to refer patients with fatty liver disease (NASH) to a liver specialist. Thirty doctors from internal medicine, family medicine, and endocrinology took part. The goal was to see …

This study looked at how the hormone glucagon affects the liver's ability to break down proteins and fats in people with obesity, type 2 diabetes, and fatty liver disease. Researchers wanted to understand if the body becomes resistant to glucagon in these conditions. A total of 2…

This study aimed to find new blood markers that can show liver damage in people with anorexia nervosa. Researchers compared blood samples from 19 patients with and without signs of liver injury. The goal is to improve detection and understanding of liver problems in this conditio…

This study looked at 10,000 older adults (age 60+) with fatty liver disease to find out what increases their risk for serious liver problems like scarring, cirrhosis, or liver cancer. Researchers used medical records and yearly check-ups to build a computer model that predicts th…

This study looked at how common liver scarring (fibrosis) is in people with anorexia nervosa. Researchers used a special scan called Fibroscan to measure liver stiffness in 43 patients when they were admitted to the hospital. The goal was to learn more about liver health in this …

This study looked at 38 adults with non-alcoholic fatty liver disease to see if gut bacteria are getting too close to the gut lining, which might worsen liver health. Researchers used a sigmoidoscopy to take tissue samples and measured the distance of microbes from intestinal cel…

This study collected blood, stomach, liver, intestine, and fat tissue from 360 severely obese patients undergoing bariatric surgery. The goal was to better understand how obesity and surgery affect the body, especially the digestive system. Researchers hope this knowledge will le…

This completed study looked at 300 liver transplant cases to understand why donor livers with fatty liver disease are more likely to be injured after transplantation. Researchers compared genetic activity in archived tissue samples from 50 cases, using advanced techniques to iden…

This study examined whether menopausal hormone therapy (MHT) can improve liver function and reduce fat buildup in the liver in postmenopausal women. 44 women were split into two groups: 22 received MHT and 22 did not. After 6 months, researchers measured liver enzymes, fat levels…

This study looked at 67 adults with type 2 diabetes and fatty liver disease who were starting a type of diabetes medication called SGLT2 inhibitors. Researchers used ultrasound and blood tests to measure changes in liver stiffness and fat after 6 months of treatment. The goal was…

This study looked at 20 teens aged 13-20 with severe obesity who were scheduled for bariatric surgery. Researchers measured liver fat and how the body processes energy before and one year after surgery. The goal was to understand how the surgery affects liver health and metabolis…

This early-stage study tested a new medicine called NNC0581-0001 in 48 adults, including healthy volunteers and people with fatty liver (hepatic steatosis). The main goal was to check safety and how the drug moves through the body after a single injection under the skin. Particip…

This study looked at 200 patients with early-stage pancreatic cancer who had Whipple surgery. Researchers found that some patients developed fatty liver within six months after surgery, which may affect nutrition, blood sugar control, and long-term survival. The goal is to help d…