Hormone therapy may improve fatty liver in menopause, small study suggests
NCT ID NCT07103603
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study examined whether menopausal hormone therapy (MHT) can improve liver function and reduce fat buildup in the liver in postmenopausal women. 44 women were split into two groups: 22 received MHT and 22 did not. After 6 months, researchers measured liver enzymes, fat levels, and fibrosis markers using blood tests and ultrasound. The goal was to see if MHT offers liver benefits during menopause.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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44 people
The number who actually took part.
- Started
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Oct 2024
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female participants aged 40 years or older * Postmenopausal status (defined as ≥12 months of amenorrhea) * No prior use of menopausal hormone therapy in the last 6 months * Willingness to participate and provide informed consent Exclusion Criteria: * History of liver disease, liver malignancy, or liver transplantation * Current or past alcohol consumption exceeding 20g/day * Premature ovarian failure * History of any active malignancy * Use of medications known to affect liver enzymes or fat metabolism * Current participation in another clinical trial
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Istanbul University - Cerrahpasa, Cerrahpasa Faculty of Medicine
Istanbul, Beyoğlu, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.
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