Essential hypertension

This study tests whether using a 21-question tool to understand a person's daily habits, then giving tailored advice, can lower blood pressure more than routine counseling. Researchers will compare two groups of adults with hypertension over three months. The goal is to see if pe…

This phase 3 trial tests a procedure called renal denervation, where a small amount of alcohol is injected around the kidney nerves to calm overactive signals that raise blood pressure. 142 people with uncontrolled hypertension will either get the real procedure or a sham (fake) …

This trial tests whether a 3-month dietary program, called the Eastern Blood Pressure-Lowering Diet, can improve blood pressure in Chinese adults with hypertension. About 800 participants from workplace canteens will either receive standard hypertension care or also get specially…

This study tests a drug called 2-HOBA in 20 adults with salt-sensitive high blood pressure. The drug aims to calm overactive immune cells that may worsen blood pressure when salt is eaten. Researchers will measure blood pressure changes and blood vessel health after taking 2-HOBA…

This study looks at whether using a smartphone app to guide slow breathing, combined with aerobic exercise, can help lower blood pressure in people with essential hypertension. Seventy-five adults aged 40-50 with stage 1-2 hypertension will be split into three groups: breathing p…

This study investigates whether Songling Xuemaikang capsules, a traditional Chinese herbal formula, can help people with both high blood pressure (hypertension) and insomnia. About 260 adults aged 18–79 with mild hypertension and sleep difficulties will take either the herbal cap…

This study looks at whether two different combinations of blood pressure and cholesterol medications can help protect kidney function in people with both high blood pressure and high cholesterol. Researchers will track changes in urine protein levels and other kidney markers over…

This study tests whether adding an 8-week online mindfulness program, called Mindfulness in Motion, to usual care helps people with high blood pressure improve their blood pressure, weight, stress, sleep, and well-being. Participants will be randomly assigned to either the mindfu…

This phase 3 trial tests whether a new drug called HCP1803-4 can safely lower blood pressure in adults with essential hypertension. Participants are randomly assigned to receive either the new drug or a control drug. The study measures changes in sitting blood pressure over time …

This pilot study tests a new device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. Twenty adults with untreated mild hypertension will either get the real procedure or a sham (fake) one. The main goal is to see if the real t…

This pilot study in Colombia will test whether a nursing program that tailors education and counseling to each patient's needs can help people with high blood pressure or type 2 diabetes stick to their medications and achieve better disease control. About 100 to 200 adults alread…

This early-stage study tests a new tablet called HS-10522 in healthy Chinese adults and those with mild hypertension. The main goal is to check safety and how the drug moves through the body. 88 participants will receive either the drug or a placebo to compare side effects and dr…

This study tests a non-invasive device that uses gentle electrical stimulation on the brain to see if it can safely lower blood pressure in people with mild hypertension. Sixty adults aged 30-65 with mild high blood pressure will receive either real or sham stimulation for 20 min…

This study tests a new, non-drug treatment for high blood pressure called high-intensity transcranial alternating current stimulation (Hi-tACS). It uses gentle electrical currents on the scalp to stimulate the brain. The trial will include 50 adults with primary hypertension to s…

This study tests whether a device that temporarily restricts blood flow to the arms (remote ischemic conditioning) can help lower blood pressure in people with hypertension who moved to high-altitude areas. 184 adults will either continue their usual medication or add the device …

This early-stage study tests a single injection of a new drug, IBI3016, in 30 Chinese adults with mild to moderate hypertension who are not currently on blood pressure medication. The main goal is to check safety and how the drug moves through the body, with a secondary look at i…

This study tests whether a daily black seed extract supplement (Nisatol®) can help lower blood pressure in women with borderline high readings or a specific nighttime blood pressure pattern. 106 women will take either the supplement or a placebo for 12 weeks. Researchers will mea…

This early-stage study tests whether a new single pill containing three blood pressure medicines works the same as taking two separate pills. The trial involves 60 healthy adults who will take both versions at different times to compare how their bodies absorb the drugs. The goal…

This study tests a 12-week program that combines a healthy diet, exercise, sleep, and stress management with a careful plan to reduce blood pressure medication. The goal is to see if people with high blood pressure can stop taking their pills and keep their blood pressure normal.…

This early-stage trial is testing a new pill called BR1015-A, which combines two common blood pressure medicines (fimasartan and indapamide) into one tablet. The study will involve 58 healthy adult volunteers to see how the body absorbs and processes the drug, and to check for an…

This early-stage trial tests a new combination pill (BR1015-A) containing two blood pressure medicines, Fimasartan and Indapamide, in 58 healthy adults. The goal is to see how the body absorbs and processes the drugs and to check for any safety issues. Participants will take the …

This early-stage trial will test a new combination pill containing two blood pressure medicines (fimasartan and indapamide) in 48 healthy adults. The study compares the combined pill to taking each drug separately, measuring how the body absorbs the drugs and checking for side ef…

This pilot study tests a device called the Netrod renal denervation system in 20 adults with uncontrolled high blood pressure who are not taking blood pressure pills. The device uses radiofrequency energy to calm overactive kidney nerves, which may help lower blood pressure. Rese…

This phase 2 trial tests five different doses of an experimental drug called BR1400 in 330 adults with essential hypertension (high blood pressure). Participants take one tablet daily for 8 weeks to see how well it lowers blood pressure and if it is safe. The study compares the d…

This study tests a 6-week program designed for people with high blood pressure who have low health literacy. Participants attend group sessions and get phone coaching to learn how to manage their condition. The goal is to see if this approach can lower blood pressure better than …

This study tests an experimental drug called IBI3016 in people with mild to moderate high blood pressure. Participants receive either the drug or a placebo as an injection every 3 or 6 months for up to 2 years. The goal is to see if the drug safely lowers blood pressure better th…

This study tests a new drug called VCT220 in 160 adults with high blood pressure who are also overweight or obese. Participants will take either VCT220 or a placebo pill for 20 weeks. The main goal is to see if VCT220 can safely lower blood pressure more than a placebo.

This study will test whether giving primary care doctors easy-to-read reports from patients' Fitbits helps them counsel patients with high blood pressure to be more active. About 330 patients and their doctors will take part. The goal is to see if this simple, low-cost approach c…

This early study tests a device that targets specific kidney nerves to lower blood pressure. About 15 adults with high blood pressure who cannot take or tolerate standard medications will receive the procedure. The goal is to see if it is safe and can reduce blood pressure for up…

This study looks at whether squeezing a handgrip device or walking is better at lowering blood pressure in people with high blood pressure. About 99 adults with stage 1 hypertension will be assigned to one of the two exercises. The goal is to see which activity leads to a greater…

This study tests whether Songling Xuemaikang capsules can help control cerebral small vessel disease (CSVD), a condition where small blood vessels in the brain get damaged over time, often linked to high blood pressure. Researchers will enroll 90 adults aged 55-75 with hypertensi…

This study compares a newer blood pressure drug, sacubitril/allisartan, to the standard drug amlodipine in 104 overweight or obese adults with high blood pressure. Participants will take one of the two drugs for 8 weeks, with dose adjustments if needed. The main goal is to see wh…

This pilot study tests whether a non-invasive brain stimulation technique called temporal interference can safely help regulate blood pressure. Researchers will enroll 25 adults with either mild untreated hypertension or hard-to-treat hypertension, as well as people with low bloo…

This study tests whether using a potassium-enriched salt substitute (75% regular salt, 25% potassium chloride) instead of regular table salt can help control blood pressure in kidney transplant recipients. About 80 participants will use either the special salt or regular salt at …

This early-stage trial will test a new drug called QLS1410 in 78 healthy adults and people with mild high blood pressure. The main goal is to check safety and how the body processes the drug. Researchers will also look at how food affects the drug and whether it lowers blood pres…

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This phase 2 trial tests whether potassium magnesium citrate, a supplement that provides key nutrients from the DASH diet, can lower blood pressure in African Americans with pre- or stage 1 hypertension. The study will enroll 45 participants and measure blood pressure over 24 hou…

This study tests whether a simple self-acupressure routine can help lower blood pressure and reduce stress in people with high blood pressure. Seventy-two adults with primary hypertension will be split into three groups: real acupressure, sham (fake) acupressure, or usual care. T…

This study tests whether tension and trauma releasing exercises (TRE) can improve quality of life and sleep in 40 adults aged 50-65 with stage 1 hypertension. Participants will do supervised TRE sessions for 8 weeks. Researchers will measure changes in sleep quality and well-bein…

This pilot study looks at how the diabetes and weight-loss drugs semaglutide and tirzepatide directly affect blood vessels and heart function, beyond their known effects on weight. Researchers will infuse the drugs into the arm or bloodstream of 112 volunteers with different body…

This pilot study will test whether a personalized computer model, called a 'digital twin,' can predict which patients with high blood pressure will respond to a procedure called renal denervation. The study will enroll 60 people, including those with resistant hypertension, untre…

This early-stage study tests how two experimental drugs (BR1015-1 and BR1015-2) are processed by the body when taken together or as a combined tablet. It involves 48 healthy adults who will receive single doses under fed conditions. The goal is to measure drug levels and check fo…

This study looks at whether different types of exercise (like walking or strength moves) and timing (morning vs. evening) can safely lower blood pressure in people with glaucoma and high blood pressure. About 60 adults will try four exercise sessions, and their blood pressure and…

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …

This study looks at whether the natural drop in blood pressure during sleep (called 'dipping') is linked to changes in the heart's electrical activity in people with high blood pressure. Researchers will monitor 140 adults using a 24-hour blood pressure device and compare those w…