Common cold

This phase 3 trial tests whether Jinhua Qinggan Granules, a traditional Chinese herbal medicine, can eliminate symptoms of acute upper respiratory infections (like fever, sore throat, and congestion) within three days. About 273 adults with early-stage cold or flu will receive ei…

This study tested whether the antiviral drug Amizon (enisamium iodide) can help adults with colds or flu feel better faster. One hundred adults aged 18 to 60 took either Amizon or a placebo pill for 7 days, starting within a day of their first symptoms. Researchers tracked sympto…

This study tested whether a special infant formula containing lactoferrin and human milk oligosaccharides (HMOs) could improve immunity in newborns. 240 healthy full-term babies were randomly assigned to receive either the test formula, a standard formula, or breast milk for 12 m…

This study tested whether the drug vapendavir can reduce breathing problems in people with COPD who catch a rhinovirus (common cold). Fifty-two adults with COPD were given either vapendavir or a placebo after being exposed to the virus. The main goal was to see if vapendavir lowe…

This study is testing new rapid tests (lateral flow and microfluidic devices) to detect respiratory infections in children and adults in Uganda, Ethiopia, and Senegal. Researchers want to see if these tests are accurate and easy to use in low-resource clinics. Participants with r…

This study is testing a new diagnostic panel called the BioFire ECoV Panel, designed to detect coronaviruses from leftover nose swab samples. Researchers will enroll 1,500 people and compare the panel's results to standard tests to see how accurate it is. The test is not being us…

This study tested whether giving general practitioners a rapid C-reactive protein (CRP) test helps them decide when antibiotics are truly needed for patients with respiratory infections. 140 patients with symptoms like cough, fever, or sore throat took part. Doctors in the test g…

This study looked at whether FebriDx, a rapid fingerstick test, can accurately tell bacterial from non-bacterial acute respiratory infections when used by people without lab training. Researchers compared results from untrained operators to trained ones in 800 patients with fever…

This study tested whether giving families educational materials, alcohol-based hand sanitizers, and surgical face masks could reduce the spread of colds and flu among household members. Researchers followed 2,788 people in 450 households in Northern Manhattan for 15 months. They …

This study tested whether the dietary supplement MitoQ could prevent severe viral infections, like COVID-19, in adults who had close contact with a sick person. Eighty asymptomatic adults were given MitoQ or no treatment and monitored for illness. The goal was to see if the suppl…

Shots and blood draws cause pain and anxiety in children, and numbing creams take time to work. Researchers are testing a device that uses cold, vibration, and distraction to block needle pain. The trial compares this device with standard numbing cream in children aged 4 to 15 at…

This trial tests whether two nasal pump sprays made from diluted seawater can safely ease symptoms of colds, rhinitis, sinusitis, and other upper respiratory infections. Participants, from 3 months old, will use one of the sprays for 7 days while doctors track symptom severity an…

This study is testing a hypertonic seawater aerosol spray (a saltwater mist) to see if it helps relieve nasal symptoms, improve sleep, and thin mucus in people with colds, sinus infections, or similar upper respiratory infections. About 110 adults and children aged 2 and older wi…

This study looked at whether taking a probiotic called LP28 can help older adults fight off colds and feel better. 102 people who had at least two colds in the past year took part. Researchers measured cold symptoms and immune cell levels to see if the probiotic made a difference…

This completed study looked at how two different Robitussin cough syrup regimens affect quality of life in 244 adults with coughs from the common cold. One group used a single daytime/nighttime syrup, while the other used separate daytime and nighttime syrups. Researchers measure…

This Phase 3 trial tested whether a single pill containing paracetamol (pain reliever/fever reducer), fexofenadine (antihistamine), and phenylephrine (decongestant) works better than a placebo for treating cold and flu symptoms. 567 adults in Brazil took the combo pill or a place…

This study looks at how regular winter swimming—bathing in cold open water during winter—affects blood cells, blood flow, and stress-fighting enzymes in healthy men. Researchers compare winter swimmers to a control group who never swim in cold water and have a sedentary lifestyle…

This study tested a drug called suzetrigine, which blocks a specific nerve channel (NaV1.8) involved in pain signaling. In 67 healthy volunteers, tiny amounts were injected into the skin alongside a placebo and lidocaine. Participants received six different types of brief pain (e…

This study looked at 537 patients with respiratory infection symptoms to see how the types of viruses and bacteria changed from the COVID-19 pandemic period to after it. Researchers used a special PCR test to detect multiple germs at once. The goal was to understand how pandemic …

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This study checked how accurate a new test (Xpert Expanded Respiratory Panel) is at finding respiratory infections. Researchers tested nose swabs from 3,200 people with symptoms and compared results to other tests. The goal was to see if the new test works well enough for routine…

This study tested whether adding infectious disease experts to primary care teams helps reduce unnecessary antibiotic use. Over 1,300 patients from six clinics in Spain took part. Doctors in the expert-advised group could call or meet with specialists to discuss tricky cases. The…

This study tested a program to help doctors prescribe antibiotics more appropriately for common childhood infections like earaches, sore throats, and sinusitis. Over 1,000 doctors took part, receiving online training, personalized feedback on their prescribing habits, and support…

This study tested a computer tool that helps nurses decide when antibiotics are needed for common respiratory infections like colds and sore throats. The tool, built into the electronic health record, calculates a patient's risk and suggests appropriate care. Researchers measured…

This completed study looked at how a special form of vitamin B3 (nicotinamide) is processed in 28 patients with low tryptophan levels due to respiratory infections or inflammatory bowel disease. Participants took either 500 mg or 1000 mg of the supplement daily for four weeks. Th…