Autoimmune disease

This study tested an extra dose of the HIPRA COVID-19 vaccine in 241 adults with conditions like HIV, kidney disease, or autoimmune disorders that weaken the immune system. The goal was to see if the booster raises antibody levels against virus variants and remains safe. Research…

This Phase 2 trial tests three commonly used drugs—lorazepam, IVIG, and tofacitinib—in 66 people aged 8 to 30 with Down Syndrome Regression Disorder (DSRD). DSRD causes sudden severe symptoms like loss of speech, movement, and daily living skills. The study aims to see if these d…

This early-phase study tested the safety of a new drug, CUG252, in 40 adults with mild-to-moderate systemic lupus erythematosus (SLE). Participants received multiple doses of the drug or a placebo by injection. The main goal was to see if the drug is safe and tolerable, and to un…

This study tested a new drug called BGB-45035 for the first time in humans. It looked at safety in healthy volunteers and then in people with autoimmune skin diseases like atopic dermatitis (eczema) and prurigo nodularis (a condition causing intensely itchy bumps). The goal was t…

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study followed 80 patients with pemphigus, a rare autoimmune disease that causes painful blisters on skin and mucous membranes. Researchers wanted to see how safe and effective rituximab (a drug that targets certain immune cells) is over the long term, compared to standard h…

This Phase 2 trial tested a drug called CFZ533 (iscalimab) in 273 adults with Sjögren's syndrome, an autoimmune disease causing dryness, pain, and fatigue. Participants received either the drug or a placebo for 24 weeks. The study measured changes in disease activity and symptoms…

This study tested a new drug called VIS649 in 155 adults with IgA nephropathy, a kidney disease. The goal was to see if the drug is safe and can reduce protein in the urine, a sign of kidney damage. Participants received either the drug or a placebo, and researchers monitored sid…

This study tested the drug eltrombopag in 34 people with moderate aplastic anemia, a condition where the bone marrow doesn't make enough blood cells. Eltrombopag is a pill that mimics a natural protein to stimulate blood cell production. Researchers measured whether it safely imp…

This early-phase trial tested a new drug called VIS171 in 61 people: first in healthy volunteers, then in patients with autoimmune diseases. The main goal was to check safety and how the body processes the drug. No results on whether it actually helps the disease are available ye…

This Phase 3 trial tested whether batoclimab, an injected antibody, can reduce eye bulging (proptosis) in people with active, moderate-to-severe thyroid eye disease. 86 participants received weekly injections of batoclimab or a placebo for 24 weeks. The main goal was to see how m…

This study tested whether tofacitinib (a JAK inhibitor drug) works better than methotrexate (a standard treatment) at reducing skin thickening in people with a severe form of scleroderma called diffuse cutaneous systemic sclerosis. Thirty-four adults with early-stage disease took…

This pilot study tested a combined bone marrow and kidney transplant from a partially matched family donor in 10 people with both a blood disorder and chronic kidney disease. The goal was to treat both conditions at once and possibly reduce the need for lifelong anti-rejection dr…

This early-stage study tested RLYB116, a small protein that blocks a part of the immune system called complement, in 16 healthy adults. The main goal was to see if it is safe and how the body handles it. Researchers also checked how well it stops complement activity. This is a fi…

This early-phase trial tested a single injection of GenSci120 in 58 healthy adults to see if it is safe and how the body processes it. The drug aims to control the immune system, which could one day help people with autoimmune diseases. Because this is a Phase 1 study, it only lo…

This study tested whether tofacitinib, a drug already approved for arthritis, is safe and helpful for immune-related skin conditions in people with Down syndrome. 47 adolescents and adults with Down syndrome and skin issues like eczema or psoriasis took the drug. Researchers chec…

This phase 2 trial tested a drug called eculizumab in 16 people with anti-GBM disease, a severe autoimmune condition that often leads to kidney failure. The drug blocks a part of the immune system believed to cause kidney damage. Researchers measured how many patients avoided dia…

This large study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of developing autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or …

This Phase 3 trial tested a drug called batoclimab in 114 adults with active, moderate-to-severe thyroid eye disease (TED). Participants received weekly injections of batoclimab or a placebo for 24 weeks. The main goal was to see if the drug could reduce eye bulging (proptosis) b…

This study looked at how well flu vaccines (seasonal and H1N1) work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or immunosuppressants. Researchers measured antibody levels three weeks after each shot to see if the vaccine provide…

This early-stage study tested a new cell therapy called MuSK-CAART in 7 people with a rare, severe form of myasthenia gravis (MuSK MG). The treatment uses a patient's own immune cells, modified to attack the harmful antibodies causing the disease. The main goal was to check safet…

This study looked at a device called GLOBAFFIN that filters antibodies from the blood to help people with autoimmune diseases. It involved 34 adults and measured how much harmful antibodies were removed and if patients felt better. The goal was to see if the device is safe and wo…

This study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tests an experimental eye drop called GRF312 5% in 100 adults with dry eye disease. The goal is to see if it is safe and helps relieve symptoms. Participants will use the drops at home and attend clinic visits for check-ups.

This completed pilot study tested an 8-week online mindfulness course in 38 people with rheumatoid arthritis. The goal was to see if patients liked the program, what barriers they faced, and how it might affect symptoms. Half the group took the course while the other half receive…

This study explores whether a powered exoskeleton—a wearable robot—can help people with moderate to severe walking problems due to multiple sclerosis (MS) exercise and walk better. Twenty-four participants will either use the exoskeleton or do standard exercises with a fitness in…

This study tested whether transcutaneous electrical acupoint stimulation (TEAS) — a gentle electrical pulse applied to specific points on the body — could reduce period pain and inflammation in women with autoimmune diseases like rheumatoid arthritis or lupus. Fifty-two women rec…

This study looked at whether a diet low in salt and sugar can reduce common side effects of corticosteroid treatment, such as weight gain, high blood pressure, and diabetes. Fifty adults with autoimmune diseases or asthma who were starting high-dose corticosteroids were randomly …

This study tested whether a 6-week self-management workshop, called the Chronic Disease Self-Management Program, could improve health and reduce healthcare use in African American women with lupus. Nearly 700 women from the GOAL study took part. The program covers topics like dea…

This study tested a non-invasive device that stimulates the vagus nerve through the ear to see if it can reduce fatigue in people with lupus. 75 participants received either active or sham stimulation over two phases. The main goal was to measure changes in fatigue using a standa…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study screened up to 1,000 people with severe allergic conditions—like anaphylaxis, eczema, and asthma—along with their relatives to find genetic causes. Researchers collected blood samples and medical history to link specific gene mutations to these diseases. No treatment w…

This study investigates whether a blood test can identify nerve damage in the bowel wall that may cause chronic constipation and defecation disorders. Researchers will compare blood samples and tissue from 100 adults undergoing surgery for obstructive defecation disorder to see i…

This study followed 190 adults who had or were about to have a stem cell transplant from a donor. Researchers tracked changes in the mouth, like dryness or sores, to learn more about chronic graft-versus-host disease (cGVHD). Participants provided saliva, mouth swabs, and had den…

This study collects medical information and biological samples (blood, urine, stool, etc.) from 32 cancer patients starting or restarting immunotherapy. The goal is to build a research database to better understand why some patients develop immune-related side effects and how to …

This study looked at how well two drugs, azathioprine and mycophenolate mofetil, work for people with myasthenia gravis in everyday medical practice. Researchers followed 82 adults with autoimmune MG for 2-3 years, measuring quality of life and side effects. The goal was to provi…

This completed study enrolled 311 people with myasthenia gravis, a condition that causes muscle weakness. Researchers collected clinical information and blood samples to build a repository for future studies. The goal is to help scientists better understand the disease and potent…

This study looked at 39 people with immune-related hair loss affecting at least half their scalp. Researchers collected blood, skin samples, and swabs to study genes, immune signals, and skin microbes. The goal was to better understand what causes alopecia, not to test a treatmen…

This completed study looked at 238 people who received a pancreas and kidney transplant for type 1 diabetes. The goal was to understand why diabetes sometimes returns even after a new pancreas is working. Researchers checked for immune system markers, like antibodies and T cells,…

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This study looked at tiny particles called microparticles in the blood and urine of people with lupus or scleroderma. Researchers wanted to see if these particles could help explain how these diseases work and possibly lead to better diagnosis or treatment. Over 200 adults partic…

This study measured phytoestrogens (plant-based compounds) in the blood and urine of 63 premenopausal women with active lupus, other autoimmune diseases, or no disease. Researchers also asked about diet and measured estradiol levels. The goal was to see if these dietary compounds…

This completed study followed 73 people with autoimmune diseases like rheumatoid arthritis or multiple sclerosis who were starting treatment with rituximab. The goal was to track how many developed serious infections and to understand what factors increase that risk. Researchers …

This completed study surveyed 121 adults with autoimmune diseases like lupus, Sjögren's syndrome, or scleroderma. Participants filled out a questionnaire about their use of alternative medicines. The goal was to find out how common these practices are in this patient group.

This 5-year study tracked over 3,000 adults with active lupus to see how safe and effective Benlysta (belimumab) is compared to standard care alone. Researchers monitored serious infections, cancers, and other side effects. The goal was to gather real-world data to help doctors a…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study tested whether coaching sessions are practical for young people with rheumatic diseases moving from pediatric to adult care. 26 participants received up to 8 coaching sessions covering self-advocacy, medication management, and future planning. The main goal was to see …

This study looked at 27 adults with a severe form of primary immunodeficiency, which causes frequent infections, enlarged lymph nodes, and low white blood cells. Researchers analyzed their DNA to find known and new genetic mutations linked to the condition. The goal was to better…

This early-phase study tested the safety and tolerability of a new drug called LAD191 in 69 healthy adults and people with an autoimmune disease. Researchers gave single or multiple doses to see how the body processes the drug and if it causes side effects. The goal was to gather…

This completed study looked at 1,000 women with autoimmune diseases (like lupus) who had a C-section. Researchers wanted to find out how many had severe bleeding (postpartum hemorrhage) and what factors increased that risk. By analyzing medical records, they hope to identify high…

This study looked at specific cells in the blood of 40 women with either Sjögren's syndrome or systemic sclerosis. The goal was to see if counting these cells could help understand the diseases better. No treatment was given; it was purely an observational study to explore potent…

This early-stage study tested two different tablet forms of the drug rilzabrutinib in 28 healthy adults. The goal was to see how well each form is absorbed by the body, both with and without food. Participants took a single dose of each tablet in a random order, with a day off be…