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Robot suit could help MS patients walk again – small trial underway

NCT ID NCT04786821

Symptom relief Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study explores whether a powered exoskeleton—a wearable robot—can help people with moderate to severe walking problems due to multiple sclerosis (MS) exercise and walk better. Twenty-four participants will either use the exoskeleton or do standard exercises with a fitness instructor twice a week for 8 weeks. The goal is to see if the exoskeleton is acceptable, safe, and can provide moderate-intensity exercise, with the hope of improving fitness and walking ability.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Phoenix Exoskeleton suit (a wearable robot) and standard exercise training
What this could lead to
If this works, it could offer a new way for people with MS to exercise and improve walking, potentially boosting fitness and quality of life.
What could go wrong
This is a small feasibility study with only 24 participants, so results may not apply to everyone. It's not designed to prove effectiveness, and using the exoskeleton may be uncomfortable or not intense enough for some.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

24 people

The number who actually took part.

Started

Jun 2022

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of MS as per the McDonald criteria (Polman et al., 2011). * Age 18 years or older. * Cognitive ability to give consent and participate in the protocol. * Walking limitations with Expanded Disability Status Scale (EDSS) scores ranging from 5.0 to 7.5. * Enough strength in hands and shoulders to support themselves standing and walking using crutches or a walker. * Meet the general requirements to fit with the Phoenix Exoskeleton (160-190.5 cm in height, weight below 80 Kg, hip width no greater than 42.7 cm measured when sitting, healthy skin where it touches Phoenix Exoskeleton). * Able to tolerate exercise twice per week as judged by the PI during screening. Exclusion Criteria: * Any illness, other than MS, affecting walking and exercise performance. * Severe cognitive or behavioral impairment. * Relapses 3 months prior to enrolment. * Change in disease modifying drugs for MS 6 months before enrolment. * Botulin toxin injections for the lower limbs the previous 3 months. * Any medical contraindications to assisted walking (e.g., cardiovascular condition, weight-bearing restrictions, osteoporosis or other fracture risk, pregnancy, uncontrolled seizure). * Significant flexion contractures limited to 35 degrees at the hip and 20 degrees at the knee that precluded Phoenix Exoskeleton fit. * Psychopathology or other health conditions that the physiotherapist, in his or her clinical judgement, considers to be exclusionary to safely use an Exoskeleton. * Living more than 20 miles away from the experiment location to reduce burden on patients due to the number of planned study visits.

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Conditions

The condition(s) this trial relates to.

autoimmune disease autoimmune disorder of the nervous system CNS demyelinating autoimmune disease multiple sclerosis Pathologic Processes Sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Autoimmune diseases Autoimmune diseases of the nervous system Demyelinating autoimmune diseases, CNS Multiple sclerosis Pathologic processes Sclerosis

Contacts and locations

Locations

  • sheffield teching hospital NHS foundation trust

    Sheffield, South Yorkshire, S10 2JF, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.