Arthritic joint disease

Researchers are testing whether apremilast helps people with early psoriatic arthritis that affects only a few joints. Participants have had symptoms for five years or less and still have joint pain and swelling despite stable treatment with NSAIDs or one conventional DMARD. The …

Researchers are testing an experimental drug called sonelokimab in adults with active psoriatic arthritis, a condition that causes painful, swollen joints along with skin psoriasis. The trial compares sonelokimab injections with placebo injections, and also includes a third group…

This study tests whether bimekizumab works better than risankizumab for adults with active psoriatic arthritis (PsA), a condition causing joint pain and skin lesions. About 684 participants will receive one of the two drugs for 16 weeks. The main goal is to see who gets at least …

This trial tests whether applying insulin gel to the skin, combined with therapeutic ultrasound (a technique called phonophoresis), can reduce pain and improve function in people with shoulder joint inflammation. Researchers compare a standard insulin gel with a nano-formulated v…

This trial tests whether a brief vocational rehabilitation program can help people with arthritis who are worried about losing their jobs. Participants, all currently employed and living or working in eastern Massachusetts, will work with a physical or occupational therapist to i…

This study looked at how to best use antibiotics to prevent infections in people having knee replacement surgery. About 1,770 adults were split into groups that got antibiotics either just before surgery or for a full day after. The goal was to see if a single dose works as well …

This phase 3 trial tested whether methotrexate, a drug used for other types of arthritis, can reduce pain and improve quality of life in people with erosive hand osteoarthritis. 64 participants received either methotrexate or a placebo once a week for 12 months. The study measure…

This study followed 152 people who received the Sidus Stem-Free Shoulder implant for severe shoulder pain and disability due to arthritis or other joint diseases. The implant is designed to replace the shoulder joint without a long stem, potentially preserving more bone. Research…

This study looked at the long-term safety and effectiveness of the Birmingham Hip Resurfacing System, a metal hip implant, in 329 adults with arthritis. The main goal was to see how many patients needed a revision (replacement or removal) within 10 years. The study also measured …

This study followed 302 children with juvenile idiopathic arthritis (JIA) who had previously taken tofacitinib in earlier studies. The goal was to see how safe the drug is over the long term, by tracking side effects, lab results, and growth. Children took tofacitinib twice daily…

This study tested whether adding vancomycin powder and a diluted povidone iodine wash during joint replacement surgery could prevent infections in high-risk patients. Over 2,100 adults with osteoarthritis who were at higher risk due to factors like obesity or smoking took part. T…

This study looked at how well a specific hip replacement system (the Allofit IT Shell with Longevity Liners) works over 10 years. 197 people with hip problems like arthritis or bone death received the implant. The main goal was to see how many implants were still in place without…

This study tested whether a weekly injection of abatacept (Orencia) plus usual care could prevent juvenile idiopathic arthritis (JIA) from spreading to more joints or causing eye inflammation. 121 children with recent-onset JIA affecting 4 or fewer joints took part. The goal was …

This study tested a new shoulder implant called PyroTITAN HRA in 156 people with arthritis. The implant resurfaces the ball part of the shoulder joint to relieve pain and improve function. Researchers tracked how long the device lasted and whether it caused problems, aiming to se…

This study tested whether rituximab, a drug used for certain cancers and autoimmune diseases, can reduce joint pain and swelling in people with systemic sclerosis (scleroderma). Twenty-two adults with active arthritis took rituximab or a placebo, plus standard care. Researchers c…

This early-phase trial tested a single infusion of stem cells taken from the patient's own belly fat in 15 adults with active rheumatoid arthritis. The main goal was to see if the treatment is safe over 12 months. Researchers also looked at whether it could lower inflammation mar…

This study tested an oral drug called upadacitinib (RINVOQ) against a placebo and an injected drug (adalimumab/Humira) in 1705 people with active psoriatic arthritis who had not responded well to standard non-biologic treatments. The goal was to see if upadacitinib reduces joint …

This study tested a smartphone app and a web-based dashboard to help people with rheumatoid arthritis track their symptoms between doctor visits. 190 participants used the app to answer daily questions about pain and function, while study staff monitored the data and connected pa…

This phase 3 study tested upadacitinib, an oral anti-inflammatory drug, in 642 adults with active psoriatic arthritis who had not responded well to at least one biologic treatment. Participants received either 15 mg or 30 mg of upadacitinib daily or a placebo. The main goal was t…

This study followed 526 adults with active psoriatic arthritis who were already prescribed apremilast (Otezla) by their doctors. Researchers observed them for up to 100 weeks to see how well the drug controlled their symptoms in everyday practice. The goal was to gather long-term…

This study tested a new panel called Synovasure RISC to see how well it helps doctors diagnose arthritis in the knee. Researchers collected fluid from the knees of 1000 people with pain or swelling. The goal was to check if the test results matched the doctor's suspected diagnosi…

This study tests whether physical therapy, combined with motivational support and planning, can help older adults with chronic hip, knee, or back pain become more physically active. Participants work with physical therapists to set personal goals and adapt activities to their con…

This trial tests a new 24-week program called COMFI that combines a cognitive behavioral approach with physical activity to help people with inflammatory arthritis manage fatigue. Participants attend group sessions, an optional individual session, and a booster session, and they …

This study looks at whether core stability exercises or ankle and foot strengthening exercises can help people with knee osteoarthritis feel better. About 100 adults aged 40 and older with moderate knee osteoarthritis will take part. The goal is to see which type of exercise redu…

This study tests whether a cream made with L-menthol and balsam copaiba oil can reduce symptoms of arthritis, joint pain, and muscle pain. Adults aged 20 to 65 with mild-to-moderate joint discomfort apply the cream or a placebo to affected areas three times daily for seven days. …

This study tests whether a powered knee exoskeleton called Keeogo can help veterans with knee osteoarthritis walk, climb stairs, and perform daily tasks with less pain compared to standard knee braces. Thirty-two veterans with moderate to severe knee osteoarthritis will try both …

This study tests a wearable device that delivers low-intensity ultrasound to the knee for 1-4 hours daily, combined with a diclofenac pain patch, to reduce pain and improve function in people with mild-to-moderate knee osteoarthritis. Participants aged 50-85 with frequent knee pa…

This study tested whether holding a simple thigh muscle contraction for 5, 10, or 20 seconds best improves strength, pain, and daily function in people with knee osteoarthritis. 127 adults aged 40-65 with mild to moderate knee arthritis took part. All also received ultrasound and…

This early study tested a single injection of a new drug, LEO 158968, in 6 people having a gout flare. The goal was to see if it could reduce joint pain. The trial is complete, but results are not yet public.

This study tested three different injections for people with painful jaw arthritis: platelet-rich plasma (PRP), hyaluronic acid, and a steroid called triamcinolone acetonide. 64 adults received one of these or a placebo saline injection. Researchers measured pain and mouth openin…

This study tested whether a single injection of amniotic suspension allograft (ASA) can reduce pain and improve function in adults with knee osteoarthritis who haven't found relief from other treatments. About 594 participants received either ASA or a placebo, and their pain and …

This study tested whether injecting a collagen product called CartiZol into the knee can reduce pain in people with osteoarthritis, cartilage damage, or injury-related arthritis. 200 adults with knee pain received either the collagen injection or a placebo (saline). The main goal…

This study tested whether injecting a mix of painkillers (bupivacaine, ketorolac, and epinephrine) around the knee during total knee replacement surgery could reduce pain and improve function better than standard pain medicines alone. Eighty adults with end-stage knee arthritis t…

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, rheumatoid arthritis, osteoarthritis, or lupus. Participants followed a 6-week walking program delivered by phone, and researchers measured changes in pain, ph…

This study tested a program called OPERAS that includes a web app for tracking symptoms and a physiotherapist who gives activity advice using a Fitbit. The goal was to see if it helps people with rheumatoid arthritis feel more confident managing their disease. 132 adults with rhe…

This study tested a dietary supplement containing Boswellia serrata, curcumin, and MSM in 100 adults with joint pain or stiffness. Participants took either the supplement or a placebo for a period, and researchers measured inflammation markers and arthritis symptoms using a stand…

This study looked at 110 obese patients (BMI over 25) having knee or hip replacement surgery under spinal anesthesia. Researchers compared two ways to calculate the dose of the sedative remimazolam: using ideal body weight versus total body weight. The goal was to find which dose…

This early-stage study tested the safety of an experimental drug called CYT-108 for people with mild to moderate knee osteoarthritis. Nineteen participants received either the drug or a placebo injection into the knee, and researchers monitored them for 26 weeks. The goal was to …

This Phase 2 trial tested a drug called LEVI-04 in 518 adults with knee osteoarthritis. The drug is designed to block pain signals. Researchers measured pain changes using a standard knee pain scale. The goal is to see if LEVI-04 can safely reduce pain and improve daily function.

This study tested an 8-week dynamic stability exercise program for people with thumb osteoarthritis. 21 adults did exercises at home and in clinic visits. Researchers measured joint alignment with CAT scans and ultrasound to see if the exercises help reduce pain and disability. T…

This study tested whether an injection made from donated human amniotic tissue and cells (called ASA) can reduce pain and improve function in people with knee osteoarthritis. Over 500 adults with moderate to severe knee OA received either ASA or a placebo (salt water) injection. …

This study tested whether a Fitbit activity tracker, a smartphone app, and phone calls with a physical therapist could help people with knee osteoarthritis become more active and sit less. Fifty-one participants were split into two groups: one received the program right away, the…

This study tested whether showing older hospitalized patients their own activity levels on a bedside screen could encourage them to move more. 130 adults aged 60+ with conditions like COPD, heart failure, or Parkinson's wore a small sensor and saw real-time feedback on time spent…

This completed study from France examined joint fluid from 20 people with arthritis to see if acid-sensing ion channels (ASICs) play a role in pain. Researchers wanted to find natural compounds that activate these channels during inflammation. The goal is to validate ASICs as tar…

This study looked at three ways to help people with rheumatoid arthritis take their methotrexate medication as prescribed: usual doctor visits, text message reminders, or a chat with a pharmacist. The goal was to see which method works best to improve adherence. The study include…

This completed study tested a smart wearable device called gaitQ that monitors and cues walking in people with long-term movement conditions like Parkinson's, stroke, multiple sclerosis, and arthritis. Researchers collected movement data from 98 participants in a lab to see if th…

This pilot study looked at how weight loss affects bone density in overweight or obese men. 44 men either followed a reduced-calorie diet to lose weight or maintained their weight for 6 months. Researchers measured changes in bone density and quality to see if weight loss has any…

This completed study looked at nearly 7,000 adults with inflammatory joint diseases like rheumatoid arthritis and psoriatic arthritis. Researchers compared two versions of a standard health survey (EQ-5D-3L and EQ-5D-5L) to see which one better measures health and quality of life…

This study looked at DNA methylation patterns in stored samples from 90 patients with rare skeletal disorders, sarcomas, or inflammatory arthritis. The goal was to better understand these patterns and explore their potential for diagnosis and treatment. The research aimed to impr…

This study looked at whether taking acetaminophen (like Tylenol) can reduce aspirin's ability to prevent heart attacks. Researchers gave 55 healthy adults and smokers both drugs in different orders to see if timing matters. The goal was to understand if acetaminophen interferes w…

This study tested whether custom carbon fiber braces can reduce harmful forces on the ankle joint after a fracture, which may lower the risk of developing arthritis. Twenty-two adults with healed ankle fractures walked with and without different brace designs while researchers me…

This study followed 225 people who had ACL reconstruction surgery to see how their knees were doing 10 years later. Researchers looked at X-rays and pain scores to find out which factors increase the risk of developing osteoarthritis. The goal is to better understand long-term ou…

This study looked at 368 patients with severe ankle arthritis who chose surgery. Researchers used surveys, step counts, and motion-capture walking tests to compare how well different surgical procedures improved function and quality of life. The goal was to find out which surgery…

This study tested four different cuff designs for carbon fiber ankle-foot orthoses (braces) in 35 healthy adults and people with ankle arthritis or injury. Researchers measured comfort, pain, foot pressure, and walking mechanics to see which cuff design people liked best. The goa…

This study looked back at 200 patients who had a knee replacement using Simplex HV bone cement. The goal was to see if the cement kept the implant in place without needing a second surgery within two years. Researchers also measured knee motion and function using the Knee Society…

This completed study looked at data from 1,000 lupus patients and gathered expert opinions to find where diagnosis and treatment fall short. Researchers reviewed existing information, discussed with doctors, and built consensus on unmet needs. The goal is to publish findings that…

This study looks at how genes might influence the severity of ankylosing spondylitis, a type of arthritis that can fuse spine bones. Researchers will follow 299 adults with the condition for up to 5 years, tracking symptoms, spine flexibility, and X-rays. The goal is to identify …

This study looked at whether special imaging techniques can predict how knee osteoarthritis will get worse over time. Researchers followed 167 people with knee osteoarthritis for 3 years, using MRI, X-rays, and bone texture analysis. The goal was to find patterns that could help …

This study reviewed medical records of 122 adults who took TNF-α inhibitors (drugs for rheumatoid arthritis and similar conditions) to find out how often they developed neutropenia—a drop in infection-fighting white blood cells. Researchers looked at blood test results and patien…

This completed pilot study tested whether training doctors to ask personalized questions (individuation) could improve care for Black and lower-income patients with rheumatic diseases like lupus and arthritis. Over 200 patients and their rheumatologists took part. The goal was to…

This study looked at 40 people who had a total hip replacement through a small incision in the front of the hip. Researchers compared two types of metal stems (AMIStem and Quadra) to see how bone density around the implant changed one year after surgery. The goal was to find out …

This study looked at how common joint pain and swelling are in 100 nursing home residents aged 65 and older, both with and without dementia. Researchers performed a physical exam and used simple pain questions or a special checklist for those with severe dementia. The goal was to…

This study tested a mixed reality system called HOLOBLUEPRINT that helps surgeons see 3D plans during shoulder replacement surgery. 44 adults having shoulder surgery used the tool. Researchers checked if the implant was placed accurately by comparing CT scans before and after sur…

This study looked at two different designs of knee replacement implants in 60 people with arthritis. The goal was to see how much each implant moved inside the bone over two years using a special X-ray technique called RSA. The findings could help surgeons pick the better implant…