Simple thigh squeezes could be key to knee pain relief
NCT ID NCT07198204
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether holding a simple thigh muscle contraction for 5, 10, or 20 seconds best improves strength, pain, and daily function in people with knee osteoarthritis. 127 adults aged 40-65 with mild to moderate knee arthritis took part. All also received ultrasound and TENS therapy. The goal is to find the simplest, most effective exercise duration to help manage symptoms.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- isometric quadriceps exercises
- What this could lead to
- If it works, this could help identify the best exercise duration to reduce pain and improve function in people with knee osteoarthritis.
- What could go wrong
- This is a small, completed trial with no blinding, so results may be biased. The exercises are simple and low-risk, but benefits may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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127 people
The number who actually took part.
- Started
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Jan 2026
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * prediagnosed case of knee OA as per the American College of Rheumatology (ACR) and radiological evidence of primary osteoarthritis of grade 3 or less on the Kellgren Lawrence scale; * age between 40-65 years, including both men and women. * unilateral or bilateral involvement (in the case of bilateral involvement, the more symptomatic knee was included). Exclusion Criteria: * Other knee joint pathologies, eg, Chondromalacia patella, plica syndrome, * Neurological disorders. * Patients having lower extremity injury/surgeries in the past 6 months, * Hip or knee fractures or deformity, * joint infections and inflammatory joint disease, * physical therapy on the knee within the last 3 months or steroid injections,
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Sphynix University
Asyut, Assuit, 71511, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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