Study reveals hidden blood risk in common arthritis drugs
NCT ID NCT07237906
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study reviewed medical records of 122 adults who took TNF-α inhibitors (drugs for rheumatoid arthritis and similar conditions) to find out how often they developed neutropenia—a drop in infection-fighting white blood cells. Researchers looked at blood test results and patient histories to determine the frequency, severity, and risk factors for this side effect. The goal was to better understand the real-world impact of these widely used medications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
122 people
The number who actually took part.
- Started
-
Sep 2023
- Finished
-
Sep 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with inflammatory arthritis who were treated with TNF-α inhibitor therapy at the Physical Medicine and Rehabilitation Department of Istanbul University-Cerrahpasa, a tertiary care center in Istanbul, Turkey, between September 2023 and January 2025.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Initiation of TNF-alpha inhibitor therapy at least once in our clinic between September 2023 and January 2025 * Age 18 years or older * At least one complete blood count performed during the follow-up period * Availability of complete clinical and laboratory data in the hospital's electronic medical records or patient files Exclusion Criteria: * History of other hematologic disorders that may contribute to the development of neutropenia (e.g., aplastic anemia, leukemia, myelodysplastic syndrome) * Concurrent treatment with cytotoxic chemotherapy or immunosuppressive agents (e.g., azathioprine, cyclophosphamide) * Insufficient follow-up duration or incomplete laboratory data that precluded adequate evaluation
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Neutropenia are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Istanbul University - Cerrahpasa (IUC)
Istanbul, 34098, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Low-Dose antifungal shield vulnerable patients from deadly fungal infections?
- Can a new protein drug shield kids with cancer from dangerous infections?
- Can a safer dose of an old drug shield vulnerable children from deadly fungal infections?
- Rare disease drug shows promise in reducing infections
- New antibiotic could shield blood cancer patients from deadly infections
- Can a single drug boost blood counts and delay cancer in High-Risk patients?