Vanderbilt University Medical Center

This phase 2 trial tests a dietary supplement called 2-HOBA in 12 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs strains the heart. Participants take the supplement three times daily for 12 weeks. The study checks if 2-HOBA i…

This study tests whether semaglutide (a GLP-1 drug used for weight loss) is safe for adolescents and young adults with Duchenne muscular dystrophy (DMD) who are also overweight or obese. The main concern is that the drug might reduce muscle mass, which is already weak in DMD. Par…

This study tests a drug called 2-HOBA in 20 adults with salt-sensitive high blood pressure. The drug aims to calm overactive immune cells that may worsen blood pressure when salt is eaten. Researchers will measure blood pressure changes and blood vessel health after taking 2-HOBA…

This study tests whether patients can safely go home within 6 hours of bariatric surgery instead of staying overnight. 200 adults with obesity will be randomly assigned to same-day discharge or overnight stay. The main goal is to see how many need emergency care within a week.

This study compares two ways to remove blood clots from the brain during a stroke. About 500 adults who have a stroke from a large blocked artery will be randomly assigned to one of two standard techniques: a cyclic 'plunger' method or a steady suction method. The goal is to see …

This study tests if combining a gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups to compare different combinations of activ…

This study looks at whether antibiotics are truly needed for mild diverticulitis. About 100 adults with left-sided diverticulitis will take either two antibiotics or a placebo daily for 10 days, along with standard pain relief and diet changes. The main goal is to see if a larger…

This study tests whether a special gel containing carbon dioxide (carboxytherapy paste) can reduce redness and swelling after microneedling, a cosmetic procedure for facial aging. Twenty adults will receive the gel on one side of their face and a placebo on the other, then be mon…

This study tests whether adding Botox injections to the jaw (masseter) and temple (temporalis) muscles can improve symptoms of facial synkinesis—a condition where facial muscles move involuntarily after nerve injury. Fifty adults will receive standard Botox treatment alone or wit…

This study tests whether giving the numbing drug lidocaine through an IV during and after major non-cardiac surgery can help patients recover faster and use fewer opioids. About 2,290 adults having elective surgery will be randomly assigned to receive lidocaine or a placebo. Rese…

This study investigates whether auditory and cognitive training can help adults with cochlear implants understand speech better. Researchers will enroll 100 experienced implant users and randomly assign them to different training programs. The goal is to see if these intervention…

This study is creating a decision aid for people with a rare heart condition called right anomalous aortic origin of a coronary artery (R-AAOCA). The condition raises the risk of sudden cardiac death, but the best management—surgery or careful observation—isn't clear. The aid wil…

This study looks at whether having physical therapy (PT) and occupational therapy (OT) together in one session works as well as having them separately for stroke patients in the hospital. About 567 adults admitted for acute stroke will be randomly assigned to either co-treatment …

This study will test a new type of colonoscope called the Magnetic Flexible Endoscope (MFE) in 6 people with inflammatory bowel disease (IBD). The MFE uses a magnet at its tip, moved by an external robotic arm, to gently travel through the colon. The goal is to see if it can reac…

This study will test a new type of eye imaging called OCT in 24 adults who have had a cornea transplant. The goal is to see if the new method can take clearer pictures of the eye to help doctors better detect eye diseases. Participants will have their eyes scanned with the new de…

This study tests whether an electronic decision-support system can help primary care doctors and specialists better manage patients with metabolic-dysfunction associated steatotic liver disease (MASLD). The tool will prompt doctors to refer high-risk patients to liver specialists…