Vanderbilt University Medical Center

This study is testing an oral compound called 2-HOBA to see if it can improve heart function and slow disease progression in people with pulmonary arterial hypertension (PAH). Researchers will enroll 12 adults with PAH to assess the drug's safety and its effects on exercise capac…

This study compares two different ways doctors use suction to remove blood clots during stroke treatment. About 500 stroke patients across 20 hospitals will be randomly assigned to receive either a rhythmic 'plunger' suction technique or continuous suction. Researchers want to se…

This study is testing whether a supplement called 2-HOBA can help lower blood pressure and calm overactive immune cells in people with lupus. 42 participants with stable lupus will take either 2-HOBA or a placebo for 4 weeks each, with a break in between. Researchers will measure…

This study is testing a computer tool that alerts doctors when a patient with fatty liver disease might need to see a specialist or get more tests. It will involve 7,200 adults and compare whether the tool helps get patients the right care faster than usual methods. The goal is t…

This study aims to find out which type of hospital therapy works better for people recovering from a recent stroke. It will compare one-on-one therapy sessions with sessions where two therapists work together with the patient. The goal is to see which approach helps patients rega…

This large study aims to determine whether the specific setting used on breathing machines (ventilators) affects how quickly critically ill patients recover and survive. Researchers will test three different ventilator modes across multiple hospital intensive care units, involvin…

This study is testing whether deep brain stimulation can improve memory and thinking skills in people with early Alzheimer's disease. Researchers will implant small electrodes in the brain to deliver mild electrical pulses to areas involved in memory. The study will measure chang…

This study is testing whether a special ketone supplement drink is safe and practical to give to patients in the intensive care unit (ICU). Researchers want to see if this drink might help reduce or shorten episodes of delirium, a state of severe confusion and disorientation that…

This study aims to find the best blood pressure target for adults recovering from brain tumor removal surgery. Researchers will compare whether keeping blood pressure below 140 mmHg or a slightly higher limit of 160 mmHg helps patients leave the hospital sooner. The goal is to sp…

This study is testing whether the medication semaglutide can help adults living with HIV drink less alcohol and smoke fewer cigarettes. Researchers want to see if reducing these habits also lowers the risk of heart disease in this population. About 200 participants will take eith…

This study is testing a new, flexible camera called the Magnetic Flexible Endoscope (MFE) to see if it can safely and comfortably examine the colon in people with stable inflammatory bowel disease (IBD). The device uses a magnet on a robotic arm outside the body to gently guide t…

This study is testing if adding a continuous lidocaine (a common numbing medicine) drip into a patient's IV during and after major surgery helps them recover faster. Researchers want to see if it shortens the hospital stay, reduces the need for strong opioid painkillers, and impr…

This study is testing if adding Botox injections to jaw and temple muscles improves treatment for a condition called facial synkinesis. People with this condition have involuntary, uncoordinated facial movements after a nerve injury. In the study, 50 participants will try their s…

This study is testing if a special gel mask containing carbon dioxide (CO2) can help skin heal faster after a microneedling treatment. Microneedling can cause temporary redness and swelling. Researchers will apply the gel to only one side of the face after the procedure to see if…

This study is testing a new method to measure oxygen levels in the tissue where two ends of the bowel are surgically reconnected. Researchers want to see if low oxygen readings can predict healing problems like leaks or narrowing. The study will observe 80 patients during their s…

This study aims to understand how common and severe swallowing problems are in older adults after a stay in the Intensive Care Unit (ICU). Researchers will measure swallowing function, strength, and quality of life in about 460 ICU survivors and some of their caregivers over seve…

This study aims to test a new, high-speed imaging camera designed to help eye surgeons see more clearly during cornea transplant operations. Researchers will use the camera on 24 adults who are scheduled for a cornea transplant to check the image quality and test new software. Th…