University Of Toronto

This study tests whether adding the HIV drug efavirenz to a person's regular antiretroviral therapy (ART) can kill cells that still harbor HIV, even when the virus is well-controlled. About 26 adults with HIV who have very low but detectable virus levels despite good medication a…

This study looks at time-restricted eating (a form of intermittent fasting) to see if the timing of your daily eating window affects blood sugar control. Researchers will compare three different 9-hour eating windows in 120 adults with obesity who have or are at risk for type 2 d…

This study looks at whether a 12-week digital diet program, including extra vegetables and soy foods, can lower blood pressure and improve heart health in 300 adults with obesity, high blood pressure, and often type 2 diabetes. Participants will either follow the diet with highly…

This study looks at how exercise and diet affect heart health in women with metabolic risks. Researchers will compare exercise alone, exercise plus diet counseling, and stretching in 180 pre- and postmenopausal women over 6 months. The goal is to see which approach best reduces i…

This study tests whether exercise and diet can reduce heart disease risk in breast cancer survivors. 45 postmenopausal women will be assigned to exercise, exercise plus diet counseling, or stretching for 6 months. Researchers will measure insulin resistance, metabolic health, and…

This study tests whether a digital heart health program (app and online sessions) added to standard care can lower cholesterol and reduce heart attacks better than standard care alone. About 1,100 adults with heart disease or high cholesterol who are already on statins will be fo…

This study looks at whether eating three servings of dairy each day can help overweight teens (ages 15-18) and seniors (ages 60-80) control their weight, body fat, and blood sugar over six months. Participants are randomly assigned to either a dairy group or a low-dairy group, an…

This study tests an online program called SCI&U that pairs people with spinal cord injury (SCI) with trained peer health coaches. The goal is to help those recently discharged from the hospital feel less emotionally distressed and more confident in managing their health. Particip…

This study looks at whether adding motivational counseling to a virtual exercise program helps cancer survivors become more active. About 236 adults who finished cancer treatment within the last 5 years will take part. They will do supervised physical activity from home and recei…

This study looks at 50 adults having knee replacement revision surgery. It compares two groups: one gets spinal morphine for pain, the other does not. Both groups receive nerve blocks. The goal is to see if skipping morphine reduces the need for a urinary catheter while still con…

This study looks at whether short bursts of physical activity after meals can help breast cancer survivors on hormone therapy manage their blood sugar better than a standard 30-minute walk. Researchers will compare different activity patterns in 24 women, including cancer survivo…

This study looks at whether a 16-week cardiac rehabilitation exercise program can improve heart health and fitness in women who have had early-stage breast cancer. About 100 participants will take part in the program at the Toronto Rehabilitation Institute. Researchers will measu…

This study tests a 6-week group therapy program for adults with psychosis. The therapy focuses on changing negative core beliefs, which are thought to drive symptoms. Researchers want to see if the program is safe, feasible, and can improve beliefs and symptoms. All 38 participan…

This study aims to see if a less invasive method (the indicator amino acid oxidation technique) can accurately measure how dietary protein helps build muscle, compared to the current gold standard that requires muscle biopsies. Eight healthy adults aged 18-35 will participate. If…

This study looks at whether the phase of your menstrual cycle (follicular vs. luteal) changes how your body responds to sprint interval training. Researchers will measure endurance performance and muscle changes in 24 healthy women over 2 weeks. The goal is to understand if timin…

This study tracks 40 women with hormone-positive breast cancer who are starting aromatase inhibitor therapy, comparing them to healthy women of similar age and weight. Researchers want to understand how this common treatment affects the heart, blood vessels, metabolism, and lifes…

This study looks at how natural menstrual cycles and birth control pills affect the way women build muscle after weightlifting. Researchers will measure muscle protein synthesis in 20 active women after exercise and a protein drink. The goal is to provide better training and nutr…

This study looks at how quickly healthy adults convert EPA (an omega-3) into DHA (another omega-3) in their blood. Researchers want to see if a person's sex and a specific gene affect this conversion rate. Participants will take EPA supplements for 12 weeks and give blood samples…

This study looks at how easy and enjoyable different exercise programs are for women going through perimenopause—the years before menopause. Researchers will compare following standard activity guidelines, doing high-intensity interval training, or stretching over 6 weeks. The go…

This study compares two rehabilitation methods to improve finger movement in 40 people who had a stroke more than 6 months ago. Participants will do 10 days of piano training and have MRI brain scans to see how the brain changes. The goal is to find out which training method work…