Sunnybrook Health Sciences Centre

This pilot study is comparing two ways to help adults in the intensive care unit (ICU) who have severe breathing failure. It tests whether using a special helmet that provides gentle air pressure, along with high-flow oxygen, works better than high-flow oxygen alone. The main goa…

This study is testing a combination of three drugs for people newly diagnosed with Waldenstrom's macroglobulinemia, a rare type of blood cancer. Participants receive standard chemotherapy (bendamustine and rituximab) for six months, plus a newer pill called acalabrutinib for one …

This small pilot study is testing if a brief course of non-invasive brain stimulation (rTMS) can help people with OCD get more benefit from standard talk therapy (CBT). Researchers want to see if stimulating the brain first can improve mental flexibility and learning, making the …

This study is testing whether a mindfulness-based therapy program can effectively reduce symptoms of Obsessive-Compulsive Disorder (OCD). It involves 420 participants across two Canadian clinics, comparing the mindfulness program to standard cognitive-behavioral therapy and a wai…

This study tests whether using inhaled anesthetic gases (like those used in surgery) to sedate critically ill COVID-19 patients on ventilators works better than standard intravenous (IV) drugs. It aims to see if the gases help more patients survive, reduce time on the ventilator,…

This study is testing whether a medication called QBECO, given as injections before and after surgery to remove colorectal cancer that has spread to the liver, can help keep the cancer from coming back. About 115 participants will receive either QBECO or a placebo (inactive subst…

This study is testing whether a lung ultrasound performed by medical trainees is as good as a standard chest X-ray at finding a collapsed lung (pneumothorax) after a chest tube is removed. It involves 60 heart surgery and trauma patients. The goal is to see if this faster, safer,…

This study is testing whether a virtual reality (VR) education session can help reduce anxiety in patients about to undergo electroconvulsive therapy (ECT). Researchers are comparing the VR experience to the standard preparation of talking with a psychiatrist. They will measure a…

This study is testing whether watching a 30-minute educational video before surgery can help patients use fewer opioid painkillers after hip or knee replacement. The video teaches safe medication use and pain coping techniques. Researchers are measuring how much opioid medication…

This study is testing whether watching immersive virtual reality videos can help reduce pain and anxiety for adults during painful dressing changes after burn surgery. The goal is to see if this distraction technique can help patients need fewer opioid painkillers. Researchers ar…

This study aims to understand how often pain-relief catheters move out of place after knee replacement surgery. Researchers will observe 100 patients to see if the catheter is still correctly positioned the day after surgery and try to identify what factors might cause it to fail…

This study aims to better understand and track different types of dementia, like Alzheimer's and vascular dementia, by observing how the brain changes over time. Researchers are using yearly MRI brain scans, genetic tests, and memory assessments on nearly 2,000 participants to cr…

This study compares virtual reality (VR) training against traditional mannequin training for teaching medical students how to manage airway trauma emergencies. Forty University of Toronto medical students were randomly assigned to learn using either VR simulations or physical man…