Sunnybrook Health Sciences Centre

This study tested a combination of three drugs (DPX-Survivac, low-dose cyclophosphamide, and pembrolizumab) in 25 adults with diffuse large B-cell lymphoma that had come back or not responded to previous treatments. The goal was to see if the immune system could be boosted to shr…

This trial looked at whether giving antibiotics after draining a perianal abscess can stop a painful fistula from forming. It involved 15 adults who had surgery for an abscess. Some got antibiotics, others did not. The main goal was to see if a larger study is even possible, not …

This study tested whether washing surgical incisions with an antiseptic (povidone-iodine) or salt water before closing them can prevent infections. Over 2,700 adults having abdominal or groin surgery were randomly assigned to one of three groups: irrigation with povidone-iodine, …

This study tested whether Dex4 chewable tablets work as well as the standard sugary drink for diagnosing gestational diabetes in pregnant women. Thirty-one women who screened positive for gestational diabetes took both tests to compare blood sugar levels and side effects. The goa…

This study tested whether a special type of PET/MRI scan using a radioactive tracer called FET can better map glioblastoma brain tumors after surgery compared to standard MRI. The goal was to see if this could help doctors plan radiation therapy more accurately. Eleven adults who…

This study tested whether a new, high-resolution ultrasound (micro-ultrasound) can find aggressive prostate cancers as well as MRI does during biopsy. Over 800 men with suspected prostate cancer were randomly assigned to one of three biopsy guidance methods. The goal was to see w…

This study tested a brief virtual therapy called MAPP (Mindful Adaptive Practice in Pregnancy) to help pregnant women manage COVID-19-related anxiety. 69 women participated, comparing MAPP to usual care. The goal was to see if the therapy is feasible and acceptable, not yet to pr…

This pilot study tested whether combining exercise with a gentle brain stimulation technique called tDCS can improve memory in 60 older adults with mild cognitive impairment or Alzheimer's disease. Participants exercised and received either real or sham tDCS. The goal was to see …

This study tested whether applying ice packs over surgical incisions every 4 hours for up to 72 hours can improve patients' recovery after chest, abdomen, or groin surgery. 196 adults were randomly assigned to receive cryotherapy plus standard care or standard care alone. The mai…

This study looked at whether drinking coffee after abdominal surgery can help the bowels start working again sooner. About 174 adults who had surgery were given either regular coffee, decaf coffee, or warm water three times a day. The main goal was to see if a larger study is pos…

This completed Phase 2 trial studied how the drug tranexamic acid (TXA) is processed in the body during hip or knee replacement surgery. 21 adults received a standard dose of TXA, and researchers measured drug levels in the blood to build a model for optimal dosing. The goal is t…

This study tested a device that gives paramedics real-time feedback on how well they are breathing for a patient during CPR after a cardiac arrest. Researchers compared breathing quality before and after using the device in over 400 patients. The goal was to see if the device hel…