Sunnybrook Health Sciences Centre

This study aims to see if a low-carb ketogenic diet can make a type of non-invasive brain stimulation more effective for adults with depression that hasn't responded to standard medications. Participants will follow either the ketogenic diet or a standard healthy diet for several…

This study tests if giving a single infusion of a migraine-prevention drug called eptinezumab within 8 weeks of a head injury can stop acute post-traumatic headaches from becoming a long-term, disabling problem. Researchers will enroll 80 adults who have developed migraine-like h…

This pilot study is testing whether a structured, team-based care plan is better than usual care for managing diabetic kidney disease. It will involve 100 adults in Ontario with type 2 diabetes and early signs of kidney problems. The goal is to see if a proactive approach to star…

This study aims to find a better way to prevent repeat strokes in people aged 75 and older. It will test if adding a very low dose of a common blood-thinning pill (edoxaban) to the standard daily aspirin or clopidogrel pill is more effective and safe than the standard pill alone.…

This small pilot study will test whether fisetin, a natural compound found in fruits and vegetables, is safe and well-tolerated in older adults with mild Alzheimer's disease or mild cognitive impairment. The research aims to gather initial safety data before larger studies. It wi…

This small pilot study aims to see if combining a fast-acting depression medication (ketamine) with immersive virtual reality (VR) is a better treatment than ketamine alone for adults with depression that hasn't responded to other medications. All 31 participants will receive sta…

This study aims to find out if a single steroid injection works as well as a 3-week course of steroid pills for reducing the pain and stiffness of a rheumatoid arthritis (RA) flare-up. Researchers will compare the two treatments in 220 adults with RA who are having a flare. The m…

This study is testing whether a new peer support program can help people recovering from serious injuries like burns or amputations. The program connects survivors with others who have experienced similar trauma to provide emotional support throughout recovery. Researchers will c…

This study aims to see if a new way of using an ultrasound machine to look at a major vein in the belly is as good as the standard method. The research will involve about 283 adults having heart surgery. Doctors want to know if the new view works well for patients who are overwei…

This study aims to understand how often patients develop a specific type of chronic nerve pain, called intercostal neuralgia, after getting a chest tube for broken ribs from an injury. Researchers will follow 100 adults for three months to track who develops this pain, identify p…

This study aims to find the best ways to position burn patients in bed to prevent painful pressure sores. Researchers will use a special mat to measure pressure on the skin of 80 adult patients in different positions. The goal is to create new guidelines for nurses and caregivers…

This study aims to see if learning to perform electroconvulsive therapy (ECT) using a virtual reality (VR) simulator is just as good as practicing on a traditional medical mannequin. Researchers will enroll 78 medical students with no prior ECT training. Students will be randomly…

This study is testing whether a new blood test can detect if triple-negative breast cancer is returning earlier than current standard scans. Thirty patients who have finished initial treatment will be randomly assigned to receive either standard follow-up care or standard care pl…