Sunnybrook Health Sciences Centre

This study looks at whether giving sedation through inhaled gases, instead of through a vein, helps critically ill COVID-19 patients on breathing machines. The goal is to see if this approach reduces swelling in the lungs, improves oxygen levels, and helps patients recover faster…

This study tests whether a drug called QBECO, given as a self-injection before and after liver surgery, can lower the chance of colorectal cancer coming back or spreading. About 115 adults with colorectal cancer that has spread to the liver will take part. The goal is to see if t…

This study tests a higher dose of radiation given over 3 weeks to adults 65 and older with glioblastoma or grade 4 astrocytoma. Using a special machine called an MR-Linac, doctors take daily MRI scans to adjust the radiation beam precisely to the tumor. The goal is to improve how…

This study tests whether adding the targeted drug acalabrutinib to standard chemotherapy (bendamustine and rituximab) improves outcomes for people with untreated Waldenstrom's macroglobulinemia, a rare blood cancer. About 63 adults will receive the combination for up to a year. T…

This study tests whether lung ultrasound performed by medical trainees can accurately detect pneumothorax (a collapsed lung) after chest tube removal in heart surgery and trauma patients. About 60 adults will get both an ultrasound and a chest X-ray, and the results will be compa…

This study tests whether magnetic stimulation of the pelvic floor can help women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 158 adult women will receive the treatment and report their symptoms using questionnaires. The goal is t…

This study tests whether a short-term mindfulness program can reduce obsessive-compulsive disorder (OCD) symptoms in 420 adults. Participants receive either mindfulness training or standard therapy, and researchers track changes in symptom severity. The goal is to see if mindfuln…

This study tests whether a laser applied to the vagina can help women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 144 women will receive the laser treatment and be followed for 6 months. The main goal is to see if the treatment r…

This study tests a laser treatment to ease vaginal dryness, itching, pain, and urinary issues caused by menopause. About 60 women aged 45-70 with moderate to severe symptoms will receive the laser therapy. The goal is to see if it improves their most bothersome symptom without ne…

This small pilot study tests whether a brief, non-invasive brain stimulation technique called rTMS can boost the effects of cognitive behavioral therapy (CBT) for people with obsessive-compulsive disorder (OCD). Ten adults with moderate to severe OCD will receive rTMS before star…

This study looks at whether watching a virtual reality (VR) video of an ECT session before the real procedure can lower anxiety and improve understanding. About 64 adults getting ECT for the first time will be randomly assigned to either a VR education session or standard prepara…

This study looks at whether a 30-minute online video, watched before hip or knee replacement surgery, can help patients use fewer opioids afterward. The video teaches safe use of pain medicines and coping techniques. About 220 adults will take part, and researchers will track how…

This study tests whether watching immersive 360-degree videos through a VR headset can reduce pain, anxiety, and the need for strong painkillers during dressing changes after burn surgery. About 80 adults who have had skin grafts will try the VR distraction during two dressing ch…

This study looks at two types of radiation for people with 5 to 30 brain tumors that have spread from other cancers. One group gets focused radiation (SRS) alone, and the other gets focused radiation plus whole-brain radiation. The goal is to see which approach better protects me…

This long-term study uses yearly brain scans, genetic tests, and thinking/memory assessments to track changes in nearly 1,800 people with various dementias (like Alzheimer's and vascular dementia) and over 140 healthy older adults. The goal is to better diagnose, monitor, and eve…

This study compares virtual reality (VR) training to traditional mannequin training for teaching medical students how to manage airway injuries. About 40 medical students will be randomly assigned to learn using either VR or a mannequin, then tested a week later. The goal is to s…

This study tests whether adding a helmet-like breathing mask to standard high-flow nasal oxygen helps adults with sudden breathing failure more than nasal oxygen alone. About 200 ICU patients will be randomly assigned to one of the two methods. The goal is to see which approach i…

This observational study looks at how often a small tube that delivers pain medicine near the knee (called an adductor canal catheter) stays in the right place the day after total knee replacement. About 100 people over age 50 having knee surgery will be checked with ultrasound t…