Sunnybrook Health Sciences Centre

This study tests whether a structured, goal-directed care plan can lower kidney and heart risks in people with diabetic kidney disease better than usual care. About 100 adults with type 2 diabetes and kidney problems will be split into two groups: one gets the new care approach, …

This study tests whether a single infusion of eptinezumab, given within 8 weeks of a mild traumatic brain injury, can reduce the number of moderate-to-severe headache days and prevent headaches from becoming chronic. About 80 adults with post-traumatic headaches that have migrain…

This study tests whether adding a very low dose of the blood thinner edoxaban (15 mg daily) to standard antiplatelet therapy can reduce the risk of another stroke in people aged 75 and older who have already had an ischemic stroke. About 1,200 participants will be randomly assign…

This pilot study tests whether a non-invasive technique called transcranial alternating current stimulation (tACS) can improve working memory in 30 adults with mild cognitive impairment or traumatic brain injury. Participants will receive tACS sessions while researchers measure m…

This study tests whether adding a ketogenic diet to a type of brain stimulation (called iTBS) can better reduce symptoms of depression in people whose depression hasn't improved with standard treatments. Sixty adults will follow either a keto diet or a standard healthy diet for s…

This study tests whether adding virtual reality (VR) to standard ketamine treatment can better ease symptoms of depression. All 31 participants will receive ketamine, and half will also use a VR headset during treatment. The main goal is to see if a larger trial is possible, but …

This study tests whether a blood test (liquid biopsy) can find signs of cancer returning in people treated for triple-negative breast cancer. Thirty participants will either get standard follow-up or standard follow-up plus regular blood tests. If the blood test shows cancer DNA,…

This study compares two ways of using ultrasound to measure the inferior vena cava, a major vein that shows how much fluid is in the body. The standard method uses a view below the breastbone, but this can be hard in patients who are obese, have surgical dressings, or feel pain a…

This study looks at how paramedics give breaths during CPR to people whose hearts have stopped. While chest compressions are well-studied, the best way to provide oxygen is not clear. Researchers will compare different ventilation methods in 1,656 adults to see which leads to mor…

This study looks at how to prevent pressure sores (bedsores) in burn patients. Researchers will use a special pressure-sensing mat to find which positions and cushions put the least pressure on high-risk spots like the heels, tailbone, elbows, and back of the head. The goal is to…

This study aims to find the right dose of enzalutamide for men aged 75 and older with advanced prostate cancer. Researchers will measure drug levels in the blood and compare them to younger patients. The goal is to reduce side effects while keeping the treatment effective.

This study looks at whether a short educational flyer can improve what women know about stress urinary incontinence (SUI), a common condition that causes bladder leaks during activities like coughing or exercise. About 90 adult women visiting a urogynecology clinic will fill out …

This study tests a new peer support program for adults recovering from serious injuries like car crashes, burns, or amputations. The program pairs survivors with trained peers who have been through similar experiences, offering support from hospital to home. The goal is to see if…

This study looks at whether virtual reality (VR) can train medical students to give electroconvulsive therapy (ECT) just as well as using a mannequin. About 78 medical students who have never learned ECT before will be randomly assigned to practice with either VR or a mannequin. …