State University Of New York At Buffalo

This study tests whether school-based health centers can improve asthma care for 400 children with uncontrolled asthma from underserved communities. The program includes guideline-based assessments, directly observed preventive medication, and self-management support. The goal is…

This study compares two methods for disinfecting root canals in teeth with apical periodontitis (an infection at the tooth root). Fifty adults with infected molars will receive either a laser-based disinfection or a standard protocol. The goal is to see which method reduces bacte…

This study tests whether eating low-protein meals (10% protein instead of the usual 20%) can boost the immune system's response to immunotherapy in cancer patients. Researchers will enroll 30 adults with solid tumors that have spread. The main goal is to see if patients can stick…

This study tests whether adding bicalutamide (a prostate cancer drug) to sunitinib (a standard kidney cancer drug) can help people whose kidney cancer has stopped responding to other targeted therapies. The trial will enroll 28 adults with advanced renal cell carcinoma. Researche…

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This pilot study is testing whether metformin, a common diabetes drug, can safely protect the nervous system in people aged 55 to 75 with multiple sclerosis (MS). Thirty participants will receive either metformin or a placebo for 9 months, and researchers will use brain scans to …

This study enrolls 45 pregnant women who use both cigarettes and e-cigarettes. Participants are split into three groups: one that tries to quit both at the same time, one that quits cigarettes first then e-cigarettes, and a control group. All receive counseling, feedback on nicot…

This study is testing a new device called TonoVera to see how well it measures pressure inside the eye compared to current methods. Researchers will enroll 300 adults with glaucoma. The goal is to find out if the new tool is accurate enough for routine use.

This study tests whether a program that encourages and supports breastfeeding can help women who quit smoking during pregnancy stay smoke-free after giving birth. Participants are randomly assigned to receive either breastfeeding promotion (including education, counseling, suppor…

This study tests whether a brief, friend-focused motivational interview can reduce the risk of alcohol-involved sexual assault. About 560 women who drink heavily and socialize together at least once a week will take part. Researchers will track changes in drinking habits and read…

This study tests whether adding continuous glucose monitoring (CGM) to the standard Diabetes Prevention Program (DPP) helps adults with prediabetes stick with healthy habits and lower their risk of developing type 2 diabetes. About 214 adults with prediabetes will receive DPP coa…

This study tests whether a 16-week hydration program can reduce side effects like nausea and dehydration in people starting GLP-1 medications (such as Ozempic or Wegovy). Researchers will track 30 adults aged 18-60 who recently started the drug, measuring hydration levels and sid…

This study tests whether using a portable oxygen concentrator (a lightweight, battery-powered device) during walking or exercise helps people with interstitial lung disease (ILD) or COPD feel less breathless and be more active in their daily lives. Twenty-four participants will t…

This study tests whether vagus nerve stimulation (VNS) paired with rehabilitation can improve leg and walking function in people who have had an ischemic stroke. Researchers will enroll 24 adults who are already approved for VNS therapy for arm problems. The goal is to see if thi…

This pilot study is testing whether intermittent fasting (with an optional plant-rich diet) is practical and helpful for 30 men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy). The main goal is to see if patients can stick with the diet, not …

This study tests whether a noninvasive brain stimulation method, combined with hand exercises, can improve grasping ability in people with chronic spinal cord injury. About 54 adults with neck-level injuries will receive either real or sham stimulation during training sessions. T…

This study is testing a 24-week community program for adults aged 60 and older. Participants will do weekly group exercise (using a SMARTfit system) and group art-making at a YMCA. Researchers want to see if this combination improves attention, balance, and the ability to do two …

This study tests whether toothbrushes with tapered bristles are better at removing plaque and reducing gum bleeding than regular round bristles, without causing scratches. About 70 adults with gum disease will use one of two toothbrushes at home for 4 weeks. Researchers will chec…

This pilot study is testing whether intermittent fasting (calorie restriction on alternate days) combined with a plant-based protein diet can help cancer patients respond better to chemotherapy. The study will enroll 30 adults with various cancers who are scheduled for chemothera…

This study tests whether a gentle brain stimulation technique called tDCS can improve motor and thinking skills in children aged 10-15 who have had a mild concussion. Ten participants will receive tDCS and be evaluated with balance, coordination, and brain imaging tests. The goal…

This study tests a brief, 4-session cognitive behavioral therapy (CBT) program for people with urologic chronic pelvic pain syndrome (UCPPS), including interstitial cystitis and chronic prostatitis. The treatment is mostly home-based with minimal therapist contact, teaching skill…

This study tests whether starting personalized aerobic exercise soon after a concussion helps active-duty military members recover faster and avoid long-term symptoms. About 168 participants will either do daily exercise plus standard care or standard care alone. The goal is to s…

This study tests two lighter pain control methods for children aged 3 to 17 who need a wrist fracture reduction. One method uses a numbing injection (hematoma block) with a low dose of ketamine, and the other uses the same block with fentanyl nasal spray. These are compared to th…

This study tests whether inhaling isopropyl alcohol (rubbing alcohol) can reduce nausea in children aged 7 to 17 in the emergency department. About 84 kids will be randomly assigned to sniff an alcohol pad, a standard nausea medicine (ondansetron), or a placebo (saline pad). The …

This study looks at whether a teacher-led program called the Early Childhood Friendship Project can help preschoolers be less aggressive and more kind. About 600 children from diverse backgrounds will take part. Researchers will measure changes in behavior, thinking skills, and e…

This study uses a device called FibroScan to measure liver stiffness and fat content in people with liver disease. The scan is non-invasive, like an ultrasound, and takes only a few minutes. Researchers aim to build a large database of these measurements to help improve future di…

This study tests whether a peer-based motivational program can help U.S. Navy service members reduce sexual violence and risky drinking. About 132 enlisted sailors who drink heavily and have a close friend in their unit will take part. They will answer questions about their behav…

This study looks at how a type of immune cell called neutrophils affects the body's response to the pneumococcal vaccine in young (21-40) and older (65+) adults. Researchers will measure how well neutrophils kill pneumonia bacteria after vaccination. The goal is to understand why…

This study tests whether it is possible to measure and improve sleep and body clock rhythms in children aged 3 to 6 who are in the pediatric intensive care unit (PICU). Researchers will use a watch-like device and saliva tests to track sleep, and try two simple approaches: bright…

This study looks at how daily vapers and cigarette smokers experience withdrawal when they stop using nicotine for 24 hours. Researchers will measure mood, cravings, attention, and other symptoms in 370 participants. The goal is to better understand nicotine dependence and help d…

This study looks at how people with schizophrenia experience nicotine withdrawal when they stop vaping or smoking for 24 hours. Researchers will compare withdrawal symptoms, mood, and thinking skills between daily vapers and daily smokers. The goal is to understand nicotine depen…

This study looks at how people with Parkinson's disease learn to understand speech and how that relates to their own speaking ability. Researchers will have 50 participants with Parkinson's do listening and speaking tasks to measure speech perception and production. The goal is t…

This study looks at whether providing meals to night-shift EMS workers can help them keep steady blood sugar levels. Forty participants will receive a meal service and track their glucose and stress. The goal is to see if this approach is practical and worth testing in a larger t…

This study aims to find the best work/rest schedule for soldiers in hot weather, so they can finish missions faster without overheating or getting too tired. Researchers will measure body temperature, strength, and heart rate in 24 healthy, active adults during exercise in the he…

This study looks at whether community pharmacies in under-resourced areas can help people find resources for social needs like food, housing, and transportation. About 1,600 adults will take part. The goal is to see if this help reduces hospital stays and emergency room visits ov…

This observational study follows 250 children from BIPOC and low-income families who are overweight or obese. Researchers will measure their food preferences, physical activity, and decision-making every year for three years to see how these factors relate to changes in body weig…

This study follows 600 black and white adults with solid tumor cancer who use cannabis at least weekly or not at all. Participants report pain, symptoms, and cannabis use through a smartphone app and surveys for one year. The goal is to understand how cannabis affects pain and op…

This study follows 450 cancer patients receiving immunotherapy to see how cannabis use affects their symptoms like pain, sleep, anxiety, and quality of life. Participants complete surveys and daily assessments over a year. The goal is to understand the benefits and risks of canna…

This study tests a new imaging device that uses light and sound to check blood flow in foot wounds. The goal is to see if this tool can help doctors decide on better treatments. About 25 people with chronic foot ulcers will take part. This is a small early study to see if the ide…

This study looks at whether patients in the ICU who need a tracheostomy can keep getting nutrition through a tube right up until surgery, instead of stopping 6 hours before. The goal is to see if this helps them get more food without increasing the risk of food getting into the l…