New York State Psychiatric Institute

This study investigates whether a non-invasive brain stimulation technique called deep rTMS can help people with moderate to severe alcohol use disorder reduce their drinking. Participants stay in a research unit for about three weeks to receive the stimulation treatment while re…

This study aims to create and test a new talk therapy designed specifically for transgender and nonbinary people struggling with alcohol use disorder. Researchers will adapt an existing therapy to better address the unique life stresses and relationship challenges this group face…

This study is testing whether adding a brain skills training program, called cognitive remediation, to standard early psychosis care helps young adults function better in work, school, and social life. It will compare two ways of delivering the training: fully in-person with a cl…

This study is testing a new type of court, called an Opioid Court, designed to quickly connect people arrested with opioid use to treatment and medication. It aims to see if this system works better than standard drug courts at helping people stay in treatment, avoid relapse, and…

This study aims to see if brain inflammation levels can predict how well people with OCD respond to an anti-inflammatory medication. Researchers will use brain scans and blood tests to measure inflammation in 21 adults with OCD who are still experiencing symptoms despite current …

This study aims to adapt and test a training program for Black churches to help prevent opioid overdose deaths. The program teaches community members how to recognize an overdose, use the reversal medication naloxone, and address stigma around addiction. It focuses on making the …

This study aims to see if a free mobile phone service can help prevent HIV and address related health issues like depression and alcohol use among teenagers in Uganda. Researchers will adapt an existing text and call system to include information on HIV prevention pills (PrEP) an…

This study is testing a brief, 4-week computer-based therapy program to see if it helps reduce symptoms of social anxiety disorder. Researchers will enroll 80 adults with social anxiety to compare two versions of the program and measure changes in anxiety, avoidance, and quality …

This study aims to understand how daily use of THC cannabis affects pain relief and the risk of developing dependence. It involves 16 healthy cannabis users who will take cannabis or a placebo daily in a controlled setting to see if pain relief decreases over time or if stopping …

This study is testing a new program to help people who are struggling with money problems and suicidal thoughts. It uses trained peer coaches to teach financial skills like budgeting and debt management, and connects people to community resources. The goal is to reduce financial …

This study is testing a new, non-opioid medication to help people get through opioid withdrawal. It compares a new under-the-tongue film (BXCL501) to an existing medication (lofexidine) and a placebo. The goal is to see if the new option is safer and works better at reducing with…

This study tested whether a new computer-based therapy could help reduce symptoms of social anxiety disorder. The therapy used eye-tracking technology during brief, twice-weekly sessions over four weeks. Researchers also used brain scans to understand how the treatment might work…

This study is not testing a new treatment. Instead, it aims to build a better data collection and learning system for existing early psychosis care programs in New York. It will enroll up to 2,100 young people (ages 16-30) who have recently experienced psychosis, along with their…

This study aims to understand brain mechanisms related to psychosis by testing how different doses of ketamine and an experimental drug called TS-134 affect brain activity in healthy volunteers. Researchers will use brain scans to measure changes after participants receive ketami…

This study aims to develop and test new computer-based assessments that measure thinking skills and everyday function in healthy older adults. It will compare these new tests against older, standard ones to see which are more reliable and less affected by repeated practice. The g…

This study aims to understand the brain mechanisms of psychosis to help develop better treatments for schizophrenia. Healthy volunteers receive a very low dose of ketamine while undergoing brain scans to measure how the drug affects brain activity. Researchers are testing differe…

This research aims to understand if air pollution a mother breathes during pregnancy affects her child's brain development and risk for ADHD. It follows a group of Puerto Rican families and uses brain scans of infants to separate pollution effects from other factors like genetics…

This study aims to understand how repeated daily use of cannabis with different THC and CBD ratios affects pain sensitivity, addiction potential, and body chemistry. Researchers will enroll 100 regular cannabis users who will stay in a controlled setting for 15 days while receivi…