New York State Psychiatric Institute

This study is testing a specially adapted form of talk therapy for transgender and nonbinary people who have alcohol use disorder. The therapy, based on interpersonal psychotherapy, is designed to address unique life experiences that may affect drinking. The study will enroll 30 …

This study tests whether a brain stimulation technique called deep rTMS can help people with alcohol use disorder drink less. Participants receive either real or sham rTMS over 3 weeks while staying in the hospital. Researchers measure changes in alcohol self-administration and c…

This study aims to see if mobile phone messages can help teens in Uganda prevent HIV and address related issues like mental health and alcohol use. Researchers will adapt an existing text and voice system to include HIV prevention info and mental health screening. About 200 adole…

This study tests whether a single injection of ketamine can quickly reduce suicidal thoughts in people with depression who come to the emergency room. About 90 participants will receive either ketamine or a sedative (midazolam) and be monitored for 24 hours. The trial is currentl…

This study tests whether D-serine, a natural brain chemical, can improve learning and memory in people with schizophrenia. Participants take D-serine or a placebo for 16 weeks while doing auditory training exercises. The goal is to see if D-serine helps the brain adapt and learn …

This study tests a new sublingual film called BXCL501 (dexmedetomidine) to reduce the unpleasant symptoms of opioid withdrawal, like anxiety, muscle pain, and nausea. About 160 adults with opioid use disorder will receive the drug, a placebo, or an existing medication (lofexidine…

This study tests a new computer therapy that uses eye-tracking to help people with social anxiety disorder. About 60 adults aged 18 to 60 will try this treatment to see if it reduces their fear and avoidance of social situations. The goal is to find a new, non-drug way to ease sy…

This study tests whether the anti-inflammatory drug celecoxib (Celebrex) can reduce obsessive-compulsive disorder (OCD) symptoms in adults who are already on medication but still struggling. Researchers will use brain scans and blood tests to measure inflammation and see if it pr…

This study looks at how to improve opioid court programs in New York State. Researchers will work with court staff and treatment providers to help defendants quickly get medication for opioid use disorder. The goal is to see if these strategies increase treatment retention, reduc…

This study is creating a learning healthcare system for OnTrackNY, a program that helps young people (ages 16-30) who have recently experienced psychosis. Researchers will collect data and feedback from participants, families, and clinicians to continuously improve care. The goal…

This study looks at how beta brain waves help the brain form flexible networks during tasks like remembering or making decisions. Researchers will record brain activity from 170 healthy adults using EEG while they perform computer-based tasks. The goal is to better understand the…

This study was designed to explore how cariprazine (Vraylar) might help people with bipolar depression by looking at its effect on a specific brain receptor (D3 dopamine). Participants would have taken cariprazine for six weeks and undergone PET scans to see how the drug works in…

This study looks at what happens when people who use cannabis regularly take it daily for two weeks. Researchers will measure pain sensitivity, feelings of a 'good drug effect,' and natural cannabis-like chemicals in the blood. The goal is to understand if daily use changes pain …

This study looks at how ketamine changes brain activity in 120 healthy adults. Participants will get either a study drug or a placebo for 4 days, and have two brain scans to measure these changes. The goal is to understand brain chemicals linked to psychosis, not to treat any dis…

This study looks at how daily cannabis smoking changes pain sensitivity and the risk of abuse in healthy adults who already use cannabis. Researchers will measure pain tolerance and withdrawal symptoms over 16 days in a controlled hospital setting. The goal is to understand if ca…

This study aimed to adapt an opioid overdose education and naloxone distribution program for Black church members, including clergy, people with opioid use disorder, and their families. The goal was to reduce stigma and increase overdose reversal skills. However, the trial was wi…

This study looks at whether air pollution exposure before birth is linked to ADHD risk in Puerto Rican children. Researchers will use brain scans (MRI) in 182 kids aged 6-11 to examine brain areas tied to attention. They also want to see if inflammation during pregnancy or sleep …

This study tests a program where trained peer coaches help people with financial hardship and suicide risk learn money management skills, create a financial plan, and connect with community resources. The program includes group and one-on-one video sessions over several months. T…

This study looks at how ketamine changes brain activity in 35 healthy volunteers. Participants will have two brain scans after receiving different doses of ketamine. The goal is to understand the brain processes linked to psychosis, not to treat any disease. The study is currentl…

This study involves 400 healthy adults aged 60-85 to test new computerized measures of thinking and daily function. Participants are randomly assigned to take either the new tests or standard tests over one year. The goal is to see if the new tests are better at detecting changes…

This study looks at whether adding cognitive remediation (computer-based brain exercises with group coaching) to standard care helps young people with early psychosis function better in daily life. About 117 participants from nine OnTrackNY programs will either get usual care or …