New York State Psychiatric Institute

This trial tests whether donepezil, a medication used for memory, can help adults with anorexia nervosa weaken the strong habits that drive restrictive eating. Ten participants will receive the drug for up to 8 weeks while staying in an inpatient unit, with weekly check-ins to mo…

This study tests whether giving buprenorphine (a medication for opioid addiction) through telemedicine works as well as in-person care. Fifty adults with opioid use disorder will be randomly assigned to either remote or in-person treatment. The main goal is to see how long people…

This study tests a mindfulness program called MINDS-UP to prevent substance use in children aged 10 to 14. About 45 kids will either take mindfulness classes plus a sports-based prevention program, or just the sports program alone. Researchers will check if the program is easy to…

This study looks at whether improving sleep can help memory and thinking in older adults with mild memory problems and sleep issues. Fifty participants aged 60-85 will receive either talk therapy for insomnia or gentle sound stimulation during sleep. Researchers will track change…

This study tests whether brief, 1-2 minute videos featuring personal stories from other parents can reduce stigma and improve help-seeking among parents of children aged 6-18 with depression, ADHD, or substance use problems. Researchers will recruit 1,600 parents online and rando…

This study tests a shared decision-making tool for antipsychotic medications in 120 young adults (ages 18-30) with early psychosis. The goal is to see if the tool helps patients feel more involved in their care and more likely to stick with treatment. Participants will use the de…

This study looks at how ketamine, a drug already used for depression, might reduce suicidal thoughts by affecting stress-related brain pathways. Researchers will give 12 adults with major depressive disorder a single ketamine infusion, then use smartphone tracking and PET brain s…

This study uses PET scans to see how two antipsychotic medications, brexpiprazole and cariprazine, bind to dopamine-3 receptors in the brains of people with schizophrenia. Forty participants take one of the drugs for 15 days and get brain scans before, after one day, and after 15…

This study uses brain scans to examine dopamine, a key brain chemical, in 115 people aged 18-30 who are at high risk for psychosis. Participants will have PET and MRI scans and be followed for up to two years to see if they develop psychosis. The goal is to understand where and w…