New York State Psychiatric Institute

This study tests whether a non-invasive brain stimulation technique called rTMS, given before cognitive-behavioral therapy, can help adults with cocaine use disorder quit. Thirty participants will receive either real or sham rTMS daily for 3 weeks, followed by 12 weeks of weekly …

This study tests whether adding a four-week aerobic exercise program to a new antipsychotic medication (olanzapine-samidorphan) can prevent the early weight gain often seen with these drugs. Thirty adults with schizophrenia, schizoaffective disorder, or bipolar disorder will take…

This study aims to find out which parts of a relapse prevention treatment work best for people with anorexia nervosa after they leave the hospital. About 60 adults who have regained a healthy weight will take part. Researchers will track weight changes, eating habits, and motivat…

This study tests whether adding buprenorphine (a partial opioid) to the standard shot XR-naltrexone helps people with opioid use disorder stay in treatment and avoid relapse. 180 adults will receive either the combo or a placebo for 24 weeks. The goal is to see if the combo impro…

This study is testing whether clozapine, a medication for schizophrenia, can reduce violent acts better than other antipsychotic drugs. Researchers will enroll 280 people with schizophrenia or schizoaffective disorder who have been violent in the past six months. Participants wil…

This study tests a vaccine that helps the body produce antibodies against oxycodone, a commonly abused prescription opioid. The goal is to reduce the drug's ability to reach the brain and lower its pleasurable effects. The trial involves 45 adults with opioid use disorder and foc…

This study tests a computer-based therapy for adults with social anxiety disorder. Researchers want to see if it reduces anxiety and improves quality of life. About 80 people aged 18 to 60 with social anxiety will participate. The therapy is designed to be a new, accessible treat…

This study compares two types of employment services for adults with obsessive-compulsive disorder (OCD) who are unemployed and want to work. All 40 participants will receive up to 12 sessions of cognitive behavioral therapy (CBT), and half will also get Individual Placement and …

This study tests whether a drug called pimavanserin can reduce rigid, repetitive behaviors in people with autism. About 30 adolescents and adults aged 12 to 40 will receive either the drug or a placebo, then switch. The goal is to see if it improves flexibility and reduces compul…

This study uses a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to explore how it changes food choices and brain activity in people with anorexia nervosa. Researchers will give a single session of rTMS to 72 women aged 18-30 w…

This study will use brain scans (PET/MRI) to see how the drug Cobenfy affects dopamine in the brains of 12 people with schizophrenia. Participants will take one of three doses of Cobenfy for 5 weeks and get a brain scan before and after treatment. The goal is to understand how th…

This study looks at how ketamine changes brain activity in 120 healthy adults. Participants will get either a study drug or a placebo for 4 days, and have two brain scans to measure these changes. The goal is to understand brain chemicals linked to psychosis, not to treat any dis…

This study tests a digital system called e-Connect that helps probation staff identify suicide risk in youth involved with the justice system and quickly connect them to mental health services. The trial involves probation and treatment staff across 9 Indiana counties. Researcher…

This study looks at whether giving mothers in Brazil an extra $40 per month (compared to just $2) can protect their children's brain development and mental health. About 450 children aged 7-10 from low-income families will be followed for 2 years. Researchers will measure stress,…