Montefiore Medical Center

This study tests a drug called DFMO in people under 40 with relapsed Ewing sarcoma or osteosarcoma who have finished all planned treatment and show no signs of cancer. The goal is to see if taking DFMO can help keep the cancer from returning. About 15 participants will take the d…

This study looks at two different methods doctors use to help patients breathe during a cardiac arrest in the hospital. One method uses a tube placed in the windpipe, and the other uses a mask-like device. The goal is to see which approach helps patients survive and breathe on th…

This study tests a smartphone app called ASTHMAXcel Voice that helps adults with asthma track their symptoms using voice recordings and simple questionnaires. About 200 English-speaking adults with persistent asthma who own a smartphone will either use the app or receive standard…

This early-phase study tests whether adding the drug venetoclax to standard chemotherapy is safe and effective for adults with newly diagnosed acute myeloid leukemia (AML) or advanced myelodysplastic syndrome (MDS). About 99 participants will receive different doses of venetoclax…

This study tests a new treatment for people with locally advanced non-small cell lung cancer who have not had treatment before. Instead of chemotherapy, patients receive two immunotherapy drugs (cemiplimab and fianlimab) before radiation. The goal is to see if this approach can s…

This study looks at whether adding the drug dupilumab to standard nasal steroid sprays can improve symptoms and sense of smell in people with chronic sinusitis and nasal polyps. It focuses on a diverse group of 60 adults, many from ethnic and racial minorities. Participants will …

This study tests whether sildenafil can reduce blood vessel damage in people with advanced heart failure who have a mechanical heart pump (LVAD). About 50 adults will receive either sildenafil or a placebo for 6 months. Researchers will use ultrasound and a tiny camera pill to ch…

This study tests a program called DOTS that helps doctors create personalized plans to gradually reduce opioid painkillers after orthopedic surgery. About 42 patients will be followed for 12 weeks after discharge to see if the tool lowers the number of pills prescribed and improv…

This study compares three types of spacer grafts (hard palate tissue, ear cartilage, and a porcine skin product) used to repair lower eyelid retraction. Researchers will measure eyelid height and track complications in 100 adults who had this surgery. The goal is to determine whi…

This study recruits 500 people who inject drugs through social media to see if online surveys and at-home HIV test kits work for prevention research. Participants fill out questionnaires and mail in self-administered HIV tests. The goal is to make HIV testing easier and reach mor…

This study tests if duloxetine, a medication, can reduce low back pain in people who didn't get better with standard pain relievers (NSAIDs). Researchers will enroll 120 adults from the emergency room and follow them for 3 months. The goal is to see if duloxetine can prevent long…

This pilot study is testing whether a one-time, 45-minute virtual reality (VR) session guided by an AI coach can help people with chronic pain who also misuse opioids. The session includes a check-in, pain coping skills training, and a stress reduction exercise. The study involve…

This study is testing a structured psychological program to help teenagers aged 10-19 who are having surgery for scoliosis. The program uses cognitive behavioral therapy techniques to reduce anxiety, pain, and depression before and after the operation. Researchers will measure ch…

This study tests whether a virtual group where older adults share personal stories can reduce loneliness and apathy. Researchers will enroll 50 people aged 60 and older who do not have dementia. Participants join online sessions and complete questionnaires about their mood and th…

This study is testing whether a special non-ablative laser can help treat scarring alopecia, a condition that causes permanent hair loss. Five adults will receive three laser treatments and attend follow-up visits over 15 months. Researchers will also study hair follicle genes to…

This study compares ibuprofen alone versus ibuprofen plus a short course of dexamethasone for people with acute nerve-related low back pain. About 132 adults visiting the emergency department will be randomly assigned to receive either dexamethasone or a placebo for two days, alo…

This pilot study looks at 10 people with a new, high-grade bone cancer (osteosarcoma) in an arm or leg. The goal is to see if removing the tumor with surgery before starting chemotherapy leads to better arm or leg function and quality of life. Participants and their surgeons will…

This study looks at whether giving antibiotics for just 24 hours around the time of placing a special antibiotic-coated brain drain works as well as giving them for the whole time the drain is in place. The goal is to find the best way to prevent serious brain infections in peopl…

This study looks at the genetic makeup of head and neck tumors to find markers that may predict how well a patient responds to treatment and their long-term outlook. Researchers will analyze tumor tissue from up to 1,000 people with suspected or confirmed head and neck growths. T…

This study looks back at medical records of up to 5,000 adults who had a brain aneurysm treated with special mesh tubes called flow diverters. Researchers want to see how well these devices work and how safe they are by checking things like successful placement, complications, an…