Imperial College London

This study tests whether an automated insulin delivery system (the Omnipod 5) can help people with type 2 diabetes who are on dialysis achieve better blood sugar control. Half of the 84 participants will use the automated system, while the other half will continue their usual ins…

This study tests whether oral semaglutide, a drug used for diabetes, is safe and can slow Alzheimer's disease. Sixty people with mild Alzheimer's will take the drug for one year. Researchers will check for side effects and use brain scans to see if the drug protects brain cells.

This study tests whether tadalafil, a drug typically used for erectile dysfunction, is safe and can help people with early Alzheimer's or mild cognitive impairment. Over one year, 244 participants will take either tadalafil or a placebo. Researchers will check for side effects an…

This study will test a new type of PET/CT scanner, called Long-Axial Field-of-View (LAFOV), to see if it can provide clearer images of blood vessel inflammation in people with large vessel vasculitis (LVV). The scanner is more sensitive and can image the whole body faster, potent…

This study will check if a blood test can find signs of Alzheimer's disease in people with early memory concerns. Researchers will test 1,000 adults aged 55 and older in primary care. The goal is to see if blood markers for amyloid and tau proteins match those found in spinal flu…

This study tests a new breath test to detect cancers of the stomach and esophagus. Participants provide a breath sample before and after drinking a special liquid. The test looks for chemicals in the breath that may signal cancer. The goal is to see if the drink makes these chemi…

This study tests whether adding 3D reconstruction and virtual reality to standard body image counselling helps patients feel better about their body after weight-loss surgery. 80 adults on the waiting list for bariatric surgery will be split into two groups: one gets traditional …

This early-stage study tests a drug called maralixibat in 28 pregnant women with intrahepatic cholestasis of pregnancy (ICP), a liver condition that causes severe itching and high bile acids. The main goal is to see if the drug is safe and tolerable for both mother and baby. Rese…

This study tests whether modafinil, a drug used for narcolepsy, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 participants will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a larger trial is possible, bu…

This study aims to see if a rapid 2-hour test for carbapenem-resistant bacteria (CPE) can reduce person-to-person spread in hospitals better than the standard 24-hour test. Researchers will screen 16,000 adult patients admitted to hospital and track who carries CPE. They will als…

This study follows people with chronic lung diseases like bronchiectasis, cystic fibrosis, and COPD to understand how bacteria become resistant to antibiotics. Researchers will collect samples and health data over time to map resistance patterns and genetic causes. The goal is to…

This study looks at how much women understand about having their labour started with medicine (induction) and how that knowledge affects their birth experience. About 82 pregnant women and 20-30 maternity staff will complete surveys and optional interviews before and after birth.…

This study will compare four different ways of following up with men after they have been treated for prostate cancer: hospital visits, GP visits, shared care, or self-management. The goal is to see which approach is safest, most effective, and makes the best use of NHS resources…

This study looks at how changes in the cells lining blood vessels relate to lung resistance in people with pulmonary artery hypertension (PAH). Researchers will measure certain blood markers and lung pressure in 6 adults with PAH. The goal is to better understand the disease, not…

This study will give healthy, vaccinated adults aged 18-50 a dose of the Omicron EG.5.1 COVID-19 variant through nose drops to safely create a mild infection. Researchers aim to find the right dose that infects 50-70% of volunteers with few or no symptoms. Participants will stay …

This study will follow 500 transgender adults starting gender-affirming hormone therapy to see how their immune systems change. By tracking immune cells and blood markers before and during treatment, researchers hope to understand why men and women have different rates of autoimm…

This study looks at whether doctors are properly reporting small cancer spots called tumor deposits in people with rectal cancer. These spots can show if the cancer is more aggressive and might need extra treatment like chemo or radiation. Researchers will compare reports from be…

This study will test whether an artificial intelligence (AI) system can detect pulmonary hypertension and other heart diseases using a smart stethoscope. Researchers will collect heart sound and ECG recordings from 1,000 adults already scheduled for routine echocardiography. The …