Imperial College London

This study is testing whether a medication called maralixibat is safe and tolerable for pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP), a liver condition that causes severe itching and elevated bile acids. The trial will involve about 28 participants to…

This study is testing if an automated insulin delivery system can help people with type 2 diabetes who are on kidney dialysis. The system uses a continuous glucose monitor and an insulin pump to automatically adjust insulin, aiming to keep blood sugar in a safe range. Researchers…

This study is testing if a pill called oral semaglutide, currently used for diabetes, is safe and might help slow Alzheimer's disease. It will involve 60 people with mild Alzheimer's to see if the drug protects the brain's communication points. The main goal is to check safety, w…

This study is testing whether tadalafil (commonly known as Cialis) can help slow down Alzheimer's disease in its early stages. Researchers will give 244 people with mild memory problems or early Alzheimer's either tadalafil or a placebo pill daily for one year to see if it's safe…

This study will compare four different approaches to follow-up care after curative prostate cancer treatment to determine which works best. It will track 100,000 men across England who have completed initial treatment, comparing hospital visits, GP care, shared care, and self-mon…

This study aims to determine if a simple blood test can help doctors diagnose Alzheimer's disease at an early stage during routine primary care visits. Researchers will enroll 1,000 adults aged 55 and older who have concerns about their memory or thinking abilities. The study wil…

This study aims to test if artificial intelligence (AI) can accurately detect pulmonary hypertension and other heart diseases. It will involve 1,000 patients getting a routine heart scan. Researchers will use a smart stethoscope to record heart sounds and electrical activity, the…

This study is testing a new, non-invasive breath test designed to detect stomach and esophageal cancer earlier. The test works by measuring tiny chemical changes in a person's breath, which may be increased by drinking a special nutrient mixture. Researchers aim to enroll 6000 pe…

This study is testing if a medication called modafinil can help reduce severe, long-term fatigue in people with Crohn's disease or ulcerative colitis. It's a small, early-stage trial to see if a larger study is possible. About 70 participants will be randomly assigned to take eit…

This study aims to understand how gender-affirming hormone therapy affects the immune system in transgender individuals. Researchers will collect blood samples from 500 people before and during hormone therapy to measure changes in immune cells and responses. The goal is to learn…

This study aims to understand how problems with the cells lining blood vessels are connected to high blood pressure in the lungs of people with pulmonary arterial hypertension (PAH). Six participants with stable PAH will take a study drug called XBD173. Researchers will measure m…

This study aims to check if doctors are properly reporting small cancer spots called 'tumor deposits' when they examine scans and tissue samples from rectal cancer patients. Researchers will review medical records from 225 patients to see if these important findings are being rec…

This study aims to create a safe, controlled model for studying Omicron COVID-19 infections in vaccinated people. Healthy adults aged 18-50 who have been vaccinated will have a small dose of the Omicron virus placed in their nose. The goal is to understand how the virus behaves a…