Imperial College London

This study tests a drug called tezepelumab in 42 adults with EGPA, a rare disease that causes inflammation in blood vessels and can damage organs. The goal is to see if the drug helps patients reach remission, meaning no active disease and low steroid use. Participants receive ei…

This early-stage study tests the safety of dostarlimab, an immunotherapy drug, in people with HIV-related Kaposi sarcoma that hasn't responded to standard HIV treatment. About 15-20 participants will receive the drug alongside their HIV therapy. The goal is to see if the drug is …

This phase II trial is testing a combination of chemotherapy (carboplatin and etoposide) with immunotherapy (pembrolizumab), followed by maintenance therapy with pembrolizumab and lenvatinib, in 20 people with advanced high-grade neuroendocrine tumors who have not had prior chemo…

This study aimed to see if the drug capivasertib could clear cancer DNA from the blood of women with ER-positive breast cancer who had finished initial treatment. The goal was to prevent the cancer from coming back or spreading. However, the study was withdrawn before any partici…

This phase 2 trial tests whether an experimental drug called XBD173 can improve blood flow in the brains of people with Alzheimer's disease. About 51 participants will take the drug or a placebo for 28 days. Researchers will use MRI scans and blood tests to measure changes in bra…

This study aimed to transplant insulin-producing cells into the front chamber of the eye for people with type 1 diabetes and poor vision. The goal was to see if the procedure was safe for the eye. However, the trial was withdrawn before enrolling any participants, so no results a…

This study in 16 healthy volunteers aims to understand how the experimental drug XBD173 binds to a protein called TSPO in the lungs. Using PET scans, researchers will measure how much drug is needed to occupy TSPO, and whether food affects drug levels. The results will help desig…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study tests whether smart devices and a habit-coaching app can help older adults (65+) stay active and healthy. Thirty participants will use a smartwatch and sleep mat with either a personalized coaching app or a standard app, or just receive an education leaflet. The goal i…

This study tests whether sending mailed invitations and assigning patient navigators can increase the number of high-risk patients who attend regular liver cancer ultrasound screenings. The trial includes 652 adults with cirrhosis or chronic hepatitis B, who are at risk for hepat…