Huashan Hospital

This early-stage study tests a new drug called YSCH-01, alone or with another drug (atezolizumab), in 10 people whose glioblastoma brain tumor has come back. The main goals are to check safety and see how many patients are alive after one year. Participants must be in fairly good…

This study tests whether empagliflozin, a diabetes drug, can improve left atrial function in 66 people with paroxysmal atrial fibrillation, high blood pressure, and abnormal glucose metabolism. The goal is to see if it can prevent heart failure. Participants will be randomly assi…

This study tests whether people with asymptomatic tuberculosis (TB) can be treated effectively with a shorter course of standard antibiotics—17 weeks instead of the usual 6 months. Researchers will compare the shorter regimen to standard treatment in 426 participants in China. Th…

This study tests whether placing live probiotic tablets into the unused part of the gut during a temporary ileostomy can improve bowel function after the stoma is reversed. 156 adults with ultra-low rectal cancer who had sphincter-saving surgery will be randomly assigned to a low…

This study compares a newer targeted drug, obinutuzumab, against a standard treatment (cyclophosphamide plus steroids) for primary membranous nephropathy, a kidney disease that can lead to kidney failure. About 144 adults with moderate to severe protein in their urine will receiv…

This study tests whether a drug called tenecteplase can help people who have had a stroke and cannot get treatment within the usual 4.5-hour window. About 890 Chinese adults with a moderate to severe stroke will receive either the drug or standard care. Doctors will use a special…

This study tests whether a 4-week course of two TB drugs works as well as the standard 3-month course to prevent active TB in students and staff who have been exposed. About 3,520 people from schools will take either the short or standard regimen. The goal is to see if the shorte…

This study looks at two different lab tests (live-cell and fixed-cell) to see which one is better at diagnosing MOGAD, a rare autoimmune disease that affects the brain and nerves. Researchers will test 240 adults who are suspected of having MOGAD, along with people who have other…

This study tests whether a specific body posture—raising the legs and tilting the head—can prevent chronic subdural hematoma from recurring after surgery. The trial will enroll 830 older adults who have had surgery for this type of brain bleed. Participants will be randomly assig…

This study tests a new, non-invasive brain stimulation method called temporal interference stimulation to see if it can safely help people with severe consciousness disorders (like a coma or vegetative state) regain awareness. The study will enroll 20 adults aged 18-75 who have b…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study is looking at how environmental factors in cities—like air pollution, noise, and lack of green space—affect people with depression, anxiety, or alcohol use disorder. Researchers will have 680 participants wear smartwatches to track heart rate, activity, and other body …

This study follows 33,000 adults with chronic hepatitis B to see how well different antiviral medicines work over up to 5 years. Researchers will compare treatments like entecavir, tenofovir, and peginterferon to find which ones best prevent liver cancer and other serious liver p…

This study aims to collect health information from 100,000 people with Parkinsonian disorders in China over 10 years. Participants use an online platform to report symptoms, quality of life, and other health details every 3 months. The goal is to better understand how the disease…

This study looks at whether growing a patient's tumor cells in the lab (called organoids) and testing drugs on them can predict how well those drugs will work in the patient. It involves 40 people with recurrent or metastatic salivary gland cancer. Researchers will compare the la…

This study enrolls 100 people with recurrent or metastatic head and neck squamous cell carcinoma. Researchers will take a small tumor sample, grow it in the lab as a 3D organoid, and test various drugs on it. They then compare the lab results to how the patient's actual tumor res…