European Institute Of Oncology

This study tests a combination of three drugs (atezolizumab, vinorelbine, and cyclophosphamide) in people with advanced triple-negative breast cancer that has come back after prior immunotherapy. The goal is to see if this combo can shrink tumors and help control the disease. Abo…

This study is for women with early-stage luminal breast cancer that has spread to only 1 or 2 lymph nodes. Instead of removing many lymph nodes from the armpit, doctors will remove only the marked suspicious node and the sentinel nodes. The goal is to see if this less invasive ap…

This study looks at how well a drug called zolbetuximab works when combined with standard chemotherapy for people with advanced stomach or gastroesophageal junction cancer that has spread. The cancer must have a specific protein (claudin 18.2) on its surface. The goal is to see i…

This study tests a treatment called cryoablation, which uses extreme cold to freeze and destroy small, low-risk breast tumors. It aims to see if freezing the tumor works as well as surgery, while offering a better quality of life with less pain, no general anesthesia, and better …

This study looks at different ways to test for PIK3CA gene mutations in people with metastatic breast cancer. The goal is to see which testing method works best so doctors can choose the right treatment for each patient. About 100 adults with a specific type of breast cancer (hor…

This study aims to improve how doctors detect HRR gene mutations in men with metastatic prostate cancer. Instead of relying on tumor tissue, which is often hard to get, researchers will use a simple blood test (liquid biopsy). The goal is to validate this new testing method so mo…

This study is developing a blood test (liquid biopsy) to detect two key genetic mutations (ESR-1 and gBRCA) in people with a common type of advanced breast cancer. The goal is to make testing easier and faster, helping doctors choose the best treatments. Researchers will also bui…

This study tests whether a short-term, periodic fasting-mimicking diet can safely lower high cholesterol and reduce side effects in post-menopausal women with early-stage breast cancer who are on hormone therapy (aromatase inhibitors). About 60 participants will be randomly assig…

This study is looking for early warning signs of serious side effects from the breast cancer drug T-DXd. Researchers will collect blood samples from 84 people with advanced breast cancer before and during treatment. The goal is to find markers that could predict who is at risk fo…

This study is testing a new tool to predict which elderly patients (70 years and older) with advanced head and neck cancer are likely to experience severe side effects from treatments like radiation and chemotherapy. The goal is to help doctors choose safer, more effective treatm…

This study looks at whether a less invasive procedure called sentinel lymph node biopsy can be safely used after chemotherapy in people with inflammatory breast cancer. Normally, these patients need more extensive surgery because their cancer is advanced. The study will enroll 75…

This study is a national survey of 200 women who have had a mastectomy (breast removal) with immediate breast reconstruction. The goal is to understand their sexual well-being after surgery. Researchers hope the results will help doctors better counsel patients before surgery and…

This study looks at whether a test called HER2DX helps doctors decide on the best treatment for people with early-stage HER2+ breast cancer. About 60 patients will take part, and doctors will use the test results to see if it changes their treatment choices. The goal is to improv…

This study aims to understand the mental health needs of cancer patients, their families, and healthcare providers. Researchers will gather information from 200 participants to design a digital platform that offers better support. The goal is to improve emotional well-being and c…

This study looks back at medical records of 34 people with advanced, fast-growing neuroendocrine tumors in the lung, thymus, or pancreas. The goal is to compare how these tumors are diagnosed and treated, and to see if patients with different tumor locations have different outcom…

This study aims to understand if emotional distress (like anxiety or depression) impacts how well first-line therapy works in people with metastatic breast cancer. Researchers will follow 1,000 patients starting standard treatments based on their cancer subtype. The goal is to se…

This study is testing whether a special whole-body MRI (DWB-MRI) can detect the return or spread of breast cancer earlier than standard methods. It involves 145 people with high-risk breast cancer types (HER2+ or triple-negative) who have had surgery. The goal is to see if earlie…

This study follows 750 women and men with a common type of breast cancer who were treated with CDK4/6 inhibitors after surgery. Researchers want to learn more about the characteristics and outcomes of those whose cancer returns. The goal is to gather real-world data to better und…

This study reviews genetic test results from nearly 2,000 people who were referred for TP53 gene testing between 2004 and 2025. Researchers want to find out how often harmful changes in this gene occur and how they differ among various groups. The goal is to better identify and c…

This study looks at genetic material from tumors found in the blood of 30 people with advanced or metastatic HER2-low breast cancer. The goal is to identify specific mutations in the cancer. This is an observational study, not a treatment trial, and aims to improve understanding …

This study is for people with laryngeal dysplasia, a precancerous throat condition. Researchers will analyze tissue samples to find genetic and immune changes that might predict progression to cancer. The goal is to better understand the disease, not to test a new treatment.

This study aims to uncover the molecular differences between the original lung tumor and cancer that has spread to other parts of the body. Researchers will analyze DNA from stored tumor samples of 25 adults with non-small cell lung cancer who are healthy enough for surgery. The …

This study is developing and testing a decision aid tool for women diagnosed with early-stage breast cancer. The tool is designed to help them make informed choices about their treatment. Researchers will compare how well the tool works in a group of 180 women who use it versus t…