Ann & Robert H Lurie Children's Hospital Of Chicago

This pilot study tests whether combining targeted therapy (MAPK inhibitors like trametinib and dabrafenib) with an immunotherapy drug (nivolumab) can safely and effectively treat children with BRAF-altered gliomas, a type of brain tumor. The study includes children with low-grade…

This trial investigates whether children with minor open fractures (type I) can be treated safely in the emergency room with irrigation, closed reduction, and antibiotics, instead of undergoing formal surgery in the operating room. The study enrolls 300 children with low-energy f…

This trial looks at two approaches for treating displaced wrist fractures in children aged 4 to 10. One group gets the standard sedated reduction (where the bone is realigned under sedation) followed by a cast. The other group gets only a cast without any realignment. The study m…

This study is testing whether repairing an additional knee ligament (the ALL) at the same time as standard ACL surgery can lower the chance of the ACL graft failing in children. About 240 kids aged 18 and under who need ACL surgery will be randomly assigned to get either the stan…

This early-phase trial is testing a new vaccine (rHSC-DIPGVax) made from pieces of tumor proteins, given together with two immunotherapy drugs (balstilimab and zalifrelimab), in children with DIPG or diffuse midline glioma. The goal is to see if the combination is safe and tolera…

This early-phase trial aims to see if it's possible to run a study of empagliflozin, a drug already used in adults for kidney disease, in 40 children with chronic kidney disease. Participants are randomly assigned to take the drug or continue usual care for 3 months. Researchers …

This study compares two ways of giving antibiotics to children with mild pneumonia: giving them right away versus waiting 72 hours to see if symptoms improve. The goal is to see if the 'watch and wait' approach can safely reduce unnecessary antibiotic use. About 2,000 children wi…

This study tests whether a mobile app, inhaler sensors, and remote coaching from an asthma coordinator can help children ages 4-17 better manage their asthma. Eighty parent-child pairs will be split into two groups: one gets the full digital toolkit with coaching, the other gets …

This study tests a special dye called Cytalux that makes cancer cells glow under near-infrared light. Surgeons use it during lung surgery to find and remove hard-to-see tumors in teens (ages 6-17) with bone cancer that has spread to the lungs. The goal is to see if the dye helps …

This study tests whether taking part in racial justice activism can prevent depression and reduce physical stress in Black and Latinx young people aged 15-20. Researchers will measure mood, stress hormones, and health markers over two years. The goal is to see if activism can be …

This study compares two approaches to help parents who have lost a child unexpectedly or traumatically. One approach gives parents a personalized list of grief resources, while the other adds a 'Grief Navigator' who actively helps them find and connect with support services. The …

This study tests a program called H-HOPE for babies born with birth defects who need surgery soon after birth. The program includes special care and support to help with feeding, growth, and brain development, while also improving parents' mental health. About 40 babies and their…

This study investigates whether brain imaging can predict how well children with cochlear implants will develop language skills. Researchers are building models to forecast long-term language outcomes in English- and Spanish-speaking children. They are also testing a parent-led c…

This study looks at why teens with obesity often regain weight after losing it. Researchers think hormones that control appetite might be involved. Over 35 weeks, 260 teens will follow a meal replacement plan and then be monitored for weight regain. The goal is to understand the …

This study asks families of children with cancer to donate their child's tumor tissue after death. Researchers will use the tissue to create lab models and share samples with other scientists. The goal is to better understand pediatric cancers and develop new treatments. Up to 15…

This study tests whether Fitbit data (like heart rate and activity) can help predict infections in children recovering from complicated appendectomy. Researchers will develop an algorithm and see if it helps doctors make decisions. 500 children aged 3-18 are being enrolled.

This study is creating a registry of 500 patients with eosinophilic gastrointestinal disorders (EGIDs), including eosinophilic esophagitis, gastroenteritis, and colitis. Researchers will collect questionnaires, endoscopy images, biopsy samples, and physical exam findings to learn…

This study tests two simple ways to support parents after their child (ages 10-17) visits the ER for suicidal thoughts or behaviors and is sent home with a safety plan. One group gets follow-up phone calls from a social worker, another gets automatic messages through MyChart, and…