VULVAR CANCER

This study tests a new drug called GI-101, either alone or with pembrolizumab or lenvatinib, in people with advanced solid tumors (cancers that have spread). The goal is to see if it is safe and works against the cancer. About 317 adults with certain cancers like lung, kidney, or…

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive solid tumors that have spread and are not responding to other treatments. About 100 people will be followed to see if their tumors shrink and how long that lasts. The goal is to provide a trea…

This study tests whether the drug belzutifan can shrink or control certain gynecologic cancers (like ovarian, endometrial, cervical, vaginal, or vulvar) that have come back or not gone away. About 32 adults with clear cell carcinoma will receive belzutifan pills. The main goal is…

This study tests a treatment called electrochemotherapy for women whose vulvar cancer has come back. It combines a chemotherapy drug with electric pulses to help the drug enter cancer cells more effectively. The goal is to shrink tumors and reduce the need for major surgery, whic…

This study tests whether giving a single dose of specially engineered immune cells (E7 TCR-T cells) before standard treatment (chemoradiation or surgery) can shrink or eliminate tumors in people with advanced HPV-related cancers. About 15 participants will have their own T cells …

This study tests whether a drug that boosts the immune system (dostarlimab), alone or with a drug that blocks blood vessel growth (bevacizumab), works better than standard chemotherapy for women whose gynecological clear cell cancer has come back. About 198 women will be randomly…

This study tests whether using MRI to guide brachytherapy (internal radiation) can better target tumors and reduce radiation exposure to nearby organs like the bladder and rectum. About 54 adults with cervical, uterine, vaginal, vulvar, or bladder cancer will receive treatment in…

This study looks at whether the things people buy at stores—like painkillers or indigestion remedies—could be early warning signs of cancer. Many cancers cause vague symptoms that people treat with over-the-counter products before seeing a doctor. Researchers will compare the sho…

This study looks at whether using a dye called indocyanine green (ICG) alone is as accurate as the usual two-method approach (ICG plus a radioactive tracer) for finding cancer that has spread to lymph nodes in early vulvar cancer. About 58 women with early-stage vulvar cancer wil…

This study tests whether Reiki, a gentle hands-on therapy, can reduce anxiety and pain in people receiving brachytherapy (internal radiation) for gynecologic cancers like endometrial, cervical, vaginal, or vulvar cancer. About 70 participants will be randomly assigned to receive …

This study looks at whether changes in a blood marker called CRP can help predict how well immunotherapy works in women with advanced gynecological cancers (cervical, endometrial, ovarian, or vulvar). Researchers will follow 120 women receiving immunotherapy plus chemotherapy and…

This study looks at whether tailoring surgery for vulvar cancer based on the tumor's HPV and p53 status can reduce the chance of cancer coming back. About 249 women with early-stage vulvar squamous cell carcinoma will have their treatment guided by these markers. The goal is to a…