SUBJECTIVE COGNITIVE DECLINE

This early-phase study tested the drug baricitinib in 17 people with Alzheimer's disease, ALS, or mild cognitive problems. The goal was to see if the drug reaches the brain and lowers inflammation linked to these diseases. Participants took baricitinib pills for 24 weeks, and res…

This completed trial tested whether a 3-month Mediterranean diet could improve thinking and physical abilities in 57 older adults who feel their memory is slipping but still score normally on tests. Participants ate either a Mediterranean diet or their usual diet, then switched. …

This study tested whether taking a daily chicken extract or a peptide supplement for two years could help prevent memory and thinking problems in healthy older adults aged 55 to 75. A total of 276 participants were randomly assigned to receive one of the two supplements or a plac…

This study tests whether time-restricted eating (fasting for 16 hours each day) can improve memory, thinking, and overall well-being in overweight adults aged 65 and older who are worried about their memory. Over 24 weeks, participants either follow the fasting plan or join a hea…

This study tested a 12-week online program called Brain Health Together for older adults with mild cognitive decline. Participants joined live-streaming exercise and education classes, plus individual coaching, all from home. The goal was to see if the program could improve think…

This study looked at whether learning to play Go or Chess can improve thinking skills in people with mild cognitive impairment or subjective cognitive decline. 80 participants were split into groups that played Go, Chess, both, or neither for 12 weeks. The researchers measured ch…

This study tested a 6-week Integrated Attention Training Program (IATP) in 120 older adults aged 60-90 who had both anxiety symptoms and subjective memory complaints. Participants were randomly assigned to either the attention training or a health education control group. The goa…

This study tested whether an 8-week mindfulness program could reduce anxiety in 168 older adults who have memory concerns but normal cognitive test scores. Participants were randomly assigned to either mindfulness training or a health education program. The goal was to see if min…

This pilot study tested whether a single dose of an oral ketone supplement could increase blood flow and improve brain connectivity in 15 older adults with subjective or mild cognitive decline. Participants had one 2-hour session including MRI scans and cognitive tests. The goal …

This study looked at 150 people with mild memory problems to see if a special MRI scan (pCASL) could give similar information to a standard PET scan. Participants had both scans, plus a spinal tap and yearly memory tests for three years. The goal was to see if the MRI could help …

This study tested an 8-week group program called My Healthy Brain for older adults with memory concerns and lifestyle risk factors for dementia. The program, delivered via Zoom, taught mindfulness and behavior change skills to help participants improve exercise, sleep, diet, and …

This study worked with 23 adults aged 50 and older who have memory concerns to design online mindfulness and lifestyle education programs. Participants joined focus groups to share their views on healthy living and web-based interventions. Their feedback will help shape future cl…

This study looked at how a drug that blocks a brain chemical called acetylcholine affects attention in older adults with mild memory concerns. Nineteen participants aged 55 and older took either the drug or a placebo and had their brain activity measured with EEG. The goal was to…