SUBJECTIVE COGNITIVE DECLINE

This study investigates whether intensively lowering systolic blood pressure with FDA-approved medications can reduce the buildup of amyloid and tau proteins in the brain—hallmarks of Alzheimer's disease. The trial enrolls adults aged 60-85 with high blood pressure who are cognit…

This study is looking for better ways to diagnose Parkinson's disease using samples that are easy to collect, like blood, skin, and nasal swabs. Researchers will compare these samples from 340 people, including those with Parkinson's, Alzheimer's, and healthy volunteers. The goal…

This study tests an 8-week group program called My Healthy Brain for adults aged 50 and older who have memory concerns but not dementia. The program teaches about lifestyle factors like exercise, sleep, and diet that may help prevent dementia. Researchers want to see if the progr…

This study tests a rideshare service where drivers are specially trained to assist older adults, including those with Alzheimer's or memory problems. The drivers help riders from door to door, even handing them off to clinic staff. The goal is to see if this service reduces misse…

This study tests whether trained older adult peer coaches can help people aged 60+ who have both depressive symptoms and subjective cognitive decline (memory concerns). Participants take part in 8 weekly video chats focused on emotional and practical support. The goal is to see i…

This study tests if shining a special near-infrared light on the head and through the nose can improve memory and brain function in older adults at risk for Alzheimer's disease. The treatment, called photobiomodulation, is low-risk and aims to boost brain cell energy. 168 partici…

This study looks at whether giving older adults (ages 60-79) personalized advice and extra support helps them follow brain-healthy habits like a Mediterranean diet, exercise, and staying socially active. Participants have mild memory concerns or are at risk for cognitive decline.…

This study tests a 4-month program that combines memory strategies with fun leisure activities like music or Spanish lessons, plus brain games. It involves 144 adults who feel their memory is getting worse but still test in the normal range. The goal is to see if this approach ca…